Effects of pentylenetetrazol on GABA receptors expressed in oocytes of Xenopus laevis: Extra-and intracellular sites of action

Neuroscience Letters

Volumn 205, Issue 2, 1996, Pages 115-118

  Bloms Funke, P ^a,b   Madeja, M ^a   Musshoff U ^a   Speckmann, E J ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Epilepsy; Ion selective microelectrodes; Oocytes; Pentylenetetrazol (PTZ); Xenopus laevis; aminobutyric acid (GABA)

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; PENTETRAZOLE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EPILEPSY; GENETIC TRANSFECTION; ION CURRENT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

ANIMALS; CELL MEMBRANE; CONVULSANTS; FEMALE; GABA ANTAGONISTS; GANGLIONIC STIMULANTS; MEMBRANE POTENTIALS; MICROELECTRODES; MICROINJECTIONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PENTYLENETETRAZOLE; QUATERNARY AMMONIUM COMPOUNDS; RATS; RECEPTORS, GABA; RNA; XENOPUS LAEVIS;

EID: 0030047587     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12391-0     Document Type: Article

References (24)

1. Bingmann, D. and Speckmann, E.-J., Actions of pentylenetetrazol (PTZ) on CA3 neurons in hippocampal slices of guinea pigs, Exp. Brain Res., 64 (1986) 94-104.
2. Butler, R.N., Recent advances in tetrazole chemistry, Adv. Heterocycl. Chem., 21 (1977) 323-435.
3. Cathala, G., Savouret, J.-F., Mendez, B., West, B.L., Karin, M., Martial, J.A. and Baxter, J.D., A method for isolation of intact, translationally active ribonucleic acid, DNA 2 (1983) 329-335.
4. A receptor function is regulated by phosphorylation in acutely dissociated guinea-pig hippocampal neurones, J. Physiol., 420 (1990) 207-221.
5. Dumont, J.N., Oogenesis in Xenopus laevis (Daudin), I: stages of oocyte development in laboratory maintained animals, J. Morphol., 136 (1972) 153-180.
6. Faingold, C.L., Seizures induced by convulsant drugs. In P.C. Jobes and H.E. Laird (Eds.), Neurotransmitters and Epilepsy, Humana Press, Clifton, 1987, pp. 215-276.
7. Klee, M.R., Shirasaki, T., Nakaye, T., Akaike, N. and Melikov, E.N., Interaction of strychnine and bicuculline with GABA- and glycine-induced chloride currents in isolated CA1 neurons. In E.-J. Speckmann and M.J. Gutnick (Eds.), Epilepsy and Inhibition, Urban und Schwarzenbergz München, 1992, pp. 93-106.
8. Leidenheimer, N.J., Browning, M.D. and Harris, R.A., GABAA receptor phosphorylation: multiple sites, actions and artifacts, Trends Pharmacol. Sci., 12 (1991) 84-87.
9. Leweke, F.M., Louvel, J., Rausche, G. and Heinemann, U., Effects of pentetrazol on neuronal activity and on extracellular calcium concentration in rat hippocampal slices, Epilepsy Res., 6 (1990) 187-198.
10. MacDonald, R.L. and Barker, J.L., Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neurons, Nature, 267 (1977) 720-721.
11. MacDonald, R.L. and Barker, J.L., Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of convulsant action, Neurology, 28 (1978) 325-330.
12. Madeja, M., Mußhoff, U. and Speckmann, E.-J., A concentration-clamp system allowing two-electrode voltage-clamp investigations in oocytes of Xenopus laevis, J. Neurosci. Methods, 38 (1991) 267-269.
13. Madeja, M., Mußhoff, U., Kuhlmann, D. and Speckmann, E.-J., Membrane currents elicited by the epileptogenic drug pentylenetetrazole in the native oocyte of Xenopus laevis, Brain Res., 553 (1991) 27-32.
14. a receptor-ionophore complex, Eur. J. Pharmacol., 288 (1994) 61-68
15. Nicholson, C. and Phillips, J.M., Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum, J. Physiol., 321 (1981) 225-257.
16. Oehme, M. and Simon, W., Microelectrode for potassium ion based on a neutral carrier and comparison of its characteristics with a cation exchanger sensor, Anal. Chim. Acta, 86 (1976) 21-25.
17. 14C) penicillin, Acta Physiol. Scand., 109 (1980) 27-36.
18. Pacheco, M.F., Fowler, J.C. and Partridge, L.D., The site of action for the convulsant effect of pentylenetetrazol, Comp. Biochem. Physiol., 68 (1981) 99-102.
19. Polenzani, L., Woodward, R.M. and Miledi, R., Expression of mammalian gamma-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes, Proc. Natl. Acad. Sci. USA, 88 (1991) 4318-4322.
20. 3H]diazepam binding in vitro: correlation with convulsant potency, Eur. J. Pharmacol., 78 (1982) 353-356.
21. Scholer, R. and Simon, W., Membranelektrode zur selektiven, potentiometrischen Erfassung organischer Kationen, Helv. Chim. Acta, 55 (1972) 1801-1809.
22. A receptors on channel function, Neuron, 5 (1990) 703-711.
23. Simmonds, M.A., Classification of some GABA antagonists with regard to site of action and potency in slices of rat cuneate nucleus, Eur. J. Pharmacol., 80 (1982) 347-358.
24. Walden, J., Lehmenkühler, A., Speckmann, E.-J. and Witte, O.W, Continuous measurement of pentylenetetrazol concentration by a liquid ion exchanger microelectrode, J. Neurosci. Methods, 11 (1984) 187-192.