Serotonin-2 and dopamine-1 binding components of clozapine in frontal cortex and striatum in the human brain visualized by positron emission tomography

Psychiatry Research - Neuroimaging

Volumn 67, Issue 1, 1996, Pages 1-10

  Lundberg, Tommie ^a   Lindström, Leif ^a   Hartvig, Per ^b   Reibring, Lars ^b   Ågren, Hans ^b   Lundqvist, Hans ^c   Fasth, Karl J ^b   Antoni, Gunnar ^b   Långström, Bengt ^b  

^a Psychiatric Research Center   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c Department of Radiation Sciences ^*  (Sweden)

Author keywords

Clozapine; Dopamine D1; Flupenthixol; Frontal cortex; Ritanserin; Serotonin2; Striatum

Indexed keywords

CLOZAPINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; FLUPENTIXOL; RITANSERIN; SEROTONIN 2 RECEPTOR;

ADULT; ARTICLE; BINDING COMPETITION; BRAIN SCINTISCANNING; CORPUS STRIATUM; DRUG RECEPTOR BINDING; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR OCCUPANCY;

EID: 0030047456     PISSN: 09254927     EISSN: None     Source Type: Journal    
DOI: 10.1016/0925-4927(96)02653-4     Document Type: Article

References (36)

1. 2 receptors: an autoradiographic analysis in rat brain. Brain Res Bull 16, 517-525.
2. Andén, N.-E. and Stock, G. (1973) Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system. J Pharm Pharmacol 25, 346-348.
3. 1 receptor. J Neurochem 47, 1822-1831.
4. Andersen, P.H. and Nielsen, E.B. (1991) Novel approaches to development of antipsychotics. Drug-News-Perspect 4, 150-157.
5. 2 receptors in the medial prefrontal cortex: microiontophoretic studies. Brain Res 506, 346-348.
6. Balsara, J.J., Jadhav, J.H. and Chandorkar, A.G. (1979) Effect of drugs influencing central serotonergic mechanisms on haloperidol-induced catalepsy. Psychopharmacology 22, 67-69.
7. 2 receptor blocking agent. Curr Ther Res 40, 492-499.
8. Bürki, H.R., Eichenberger, E. and Sayers, A.C. (1975) Clozapine and the dopamine hypothesis in schizophrenia, a critical appraisal. Pharmacopsychiatry/Neuropsychopharmacology 8, 115-121.
9. Eriksson, L., Bohm, C., Kesselberg, M., Blomquist, G., Litton, J., Widén, L., Bergström, M., Eriksson, K. and Greitz, T. (1982) A four ring positron camera system for emission tomography of the brain. IEEE Trans Nucl Sci 29, 539-543.
10. 2 dopamine receptors by PET. Psychopharmacology 94, 471-478.
11. Fitton, A. and Heel, R.C. (1990) Clozapine: a review of its pharmacological properties, and therapeutic use in schizophrenia. Drugs 40, 722-747.
12. Gerlach, J., Koppelhus, H., Helweg, E. and Monrad, A. (1974) Clozapine and haloperidol in a single-blind cross-over trial: therapeutic and biochemical aspects in the treatment of schizophrenia. Acta Psychiatr Scand 50, 410-424.
13. 3H-raclopride. J Neural Transm 73, 7-21.
14. 11C]DOPA in humans studied by positron emission tomography. J Neural Transm 86, 25-41.
15. 11C-labelled dopamine receptor antagonists in the brain of rhesus monkeys studied with positron emission tomography. Acta Neurol Scand 77, 314-321.
16. 11C]clozapine in the brain of the rhesus monkey studied by positron emission tomography (PET). Psychopharmacology 89, 248-252.
17. 11C-tyrosine in mouse brain. J Pharm Pharmacol 26, 588-596.
18. Kane, J., Honigfeld, G., Singer, J. and Meltzer, H. (1988) Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatry 45, 789-96.
19. Korsgaard, S., Gerlach, J. and Christensen, E. (1985) Behavioral aspects of serotonin-dopamine interaction in the mon-key. Eur J Pharmacol 118, 245-252.
20. 11C-methyliodide in N-alkylation reactions of C-11-labelled radiopharmaceuticals. J Label Comp Radiopharmaceut 21, 1200-1202.
21. 11C-labelled alkaloids. Chem Scrip 20, 46-48.
22. Lindström, L. H. (1989) A retrospective study on the long-term efficacy of clozapine in 96 schizophrenic and schizoaffective patients during a 13-year period. Psychopharmacology 99, 84-86.
23. Lundberg, T., Lindström, L.H., Hartvig, P., Eckernäs, S.Å., Ekblom, B., Lundqvist, H., Fasth, K.J., Gullberg, P. and Långström, B. (1989) Striatal and frontal cortex binding of C-labelled clozapine visualized by positron emission tomography (PET) in drug-free schizophrenics and healthy volunteers. Psychopharmacology 99, 8-12.
24. 2 receptor density in rat cerebral cortex. Life Sci 45, 1397-1406.
25. Meltzer, H.Y. (1992) The importance of serotonin-dopamine interactions in the action of clozapine. Br J Psychiatry 160 (Suppl. 17), 22-29.
26. Meltzer, H.Y. and Stahl, S.M. (1976) The dopamine hypothesis of schizophrenia: a review. Schizophr Bull 2, 19-76.
27. 2 receptor-mediated function: behavioural indices. Eur J Pharmacol 186, 79-86.
28. 2 receptor occupancy of Leponex (LEX) in schizophrenic patients: open study. Psychopharmacology 110, 365-367.
29. 14C-tyrosine. Pharmacol Ther 2, 49-63.
30. Peroutka, S.J. and Snyder, S.H. (1980) Relationship of neuroleptic drug effects at brain dopamine, serotonin, adrenergic and histamine receptors to clinical potency. Am J Psychiatry 137, 1518-1522.
31. Pickar, D., Owen, R.R., Litman, R.E., Konicki, E., Gutierrez, R. and Rapaport, M.H. (1992) Clinical and biological response to clozapine in patients with schizophrenia: crossover comparison with fluphenazine. Arch Gen Psychiatry 49, 345-353
32. Salmon, E., Brooks, D.J., Leenders, K.L., Turton, D.R., Hune, S. P., Cremer, J.E., Jones, T. and Frackowiak, R.S.J. (1990) A 2-compartment description and kinetic procedure for measuring regional cerebral [C-11]nomifensine uptake using positron emission tomography. J Cereb Blood Flow Metab 10, 307-316.
33. Snyder, S., Greenberg, D. and Yamamura, H.I. (1974) Antischizophrenic drugs and brain cholinergic receptors. Arch Gen Psychiatry 31, 58-61.
34. 18F)fluoro-/-dopa in Parkinson's Disease measured with positron emission tomography. Acta Neurol Scand 81, 24-30.
35. Wadenberg, M.-L., Ahlenius, S. and Svensson, T.H. (1992) Potency mismatch for behavioral and biochemical effects by dopamine receptor antagonists: implications for the mechanism of action of clozapine. Psychopharmacology 110, 273-279.
36. Van Tol, H.H.M., Bunzow, J.R., Guan, H.C., Sunahara, R.K. and Seeman, P. (1991) Cloning of the gene for a dopamine D-4 receptor with high affinity for the antipsychotic clozapine. Nature 350, 610-614.