Needle biopsy of hepatocellular carcinoma: Assessment of prognostic contribution of histologic parameters including proliferating cell nuclear antigen labeling and correlations with clinical outcomes

Cancer

Volumn 77, Issue 5, 1996, Pages 864-871

  Chapel, Françoise ^a   Guettier, Catherine ^a   Chastang, Claude ^b   Rached, Antoine Abou ^a   Mathieu, Didier ^a   Tepper, Maryline ^a   Beaugrand, Michel ^a   Trinchet, Jean Claude ^a   Oberti, F ^c   Ruget, O ^c   Cales, P ^c   Caron Poitreau, C ^c   Trinchet, J C ^a   Abou Rached, A ^a   Ajavon, Y ^a   Beaugrand, M ^a   Dumas, F ^d   Couzigou, P ^d   Drouillard, J ^d   Balabaud, C ^e   Grelet, P ^e   Grubel, A ^f   Melange M ^f   Pringot, J ^f   Van Beers, B ^f   Hadengue, A ^g   Vilgrain, V ^g   Erlinger, S ^g   Duvoux, C ^h   Mathieu, D ^h   Dhumeaux, D ^h   Zarski, J P ⁱ   Dalsoglio, S ⁱ   Mion, F ^j   Valette, P J ^j   Paliard, P ^j   Claudel Bonvoisin, S ^k   Emery, J C ^k   Descos, L ^k   Dagenais, M ^l   Dufresne, M P ^l   Lapointe, R ^l   Huet, P M ^l   Bas, V ^m   Regent, D ^m   Bazin, C ^m   Bigard, M A ^m   Humeau, B ^n,o   Bury, A ^n,o   Le Rhun, M ^n,o   Lerat, F ^n,o   Gibaud, H ^n,o   Rymer, R ^n,o   Le Bodic, L ^n,o   Masliah, C ^p   Pouliquen, B ^p   Perrin, D ^p   Chastang, C ^b   Chazouilleres O ^q   Loria, A ^q   Poupon, R ^q   Pauwels, A ^q   Mostefa Kara, N ^q   Levy V G ^q   Balladur, P ^q   Deutsh, J P ^q   Tubiana, J M ^q   Pol, S ^r   Berthelot, P ^r   Valla, D ^s   Bousquet, J C ^s   Opolon, P ^s   Bouvry, M ^t   Labadie, H ^u   Martin, T ^v   Bronowicki, J P ^w   Vetter, D ^w   Wenger, J J ^x   Buscail, L ^y   Frexinos, J ^y   Joffre, F ^y   more..

^a HÔPITAL JEAN VERDIER   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c ANGERS UNIVERSITY HOSPITAL   (France)

^d HAUT LÉVÊQUE HOSPITAL   (France)

^e HÔPITAL SAINT ANDRÉ   (France)

^f UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

^g BEAUJON HOSPITAL   (France)

^h HENRI MONDOR HOSPITAL   (France)

ⁱ HÔPITAL MICHALLON   (France)

^j EDOUARD HERRIOT HOSPITAL   (France)

^k CENTRE HOSPITALIER LYON SUD   (France)

^l UNIVERSITY OF MONTREAL   (Canada)

^m UNIVERSITY HOSPITAL OF NANCY   (France)

ⁿ Hop Guillaume et Renee Laennec   (France)

^o CHU de Nantes   (France)

^p HÔTEL DIEU   (France)

^q HÔPITAL SAINT ANTOINE   (France)

^r HÔPITAL NECKER ENFANTS MALADES   (France)

^s PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^t CENTRE HOSPITALIER   (France)

^u DELAFONTAINE HOSPITAL   (France)

^v Centre Hospitalier Géneral   (France)

^w UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^x Clinique de l'Orangerie Strasbourg   (France)

^y TOULOUSE UNIVERSITY HOSPITAL   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER STAGING; CANCER SURVIVAL; DIAGNOSTIC VALUE; FOLLOW UP; HUMAN; LIVER BIOPSY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MITOSIS INDEX; NEEDLE BIOPSY; PRIORITY JOURNAL; PROGNOSIS; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BILIRUBIN; BIOPSY, NEEDLE; CARCINOMA, HEPATOCELLULAR; CHEMOEMBOLIZATION, THERAPEUTIC; FEMALE; FOLLOW-UP STUDIES; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MITOTIC INDEX; NEOPLASM STAGING; OUTCOME ASSESSMENT (HEALTH CARE); PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROSPECTIVE STUDIES; SERUM ALBUMIN; STAINING AND LABELING; SURVIVAL ANALYSIS;

EID: 0030047021     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0142(19960301)77:5<864::aid-cncr9>3.0.co;2-e     Document Type: Article

References (61)

1. Adachi E, Hashimoto H, Tsuneyoshi M. Proliferating cell nuclear antigen in hepatocellular carcinoma and small cell liver dysplasia. Cancer 1993;72:2902-9.
2. Haratake J, Takeda S, Kasai T, Nakano S, Tokui N. Predictable factors for estimating prognosis of patients after resection of hepatocellular carcinoma. Cancer 1993;72:1178-83.
3. Kitamoto M, Nakanishi T, Kira S, Kawaguchi M, Nakashio R, Suemori S, et al. The assessment of proliferating cell nuclear antigen immunohistochemical staining in small hepatocellular carcinoma and its relationship to histologic characteristics and prognosis. Cancer 1993;72:1859-65.
4. Higuchi T, Kikuchi M, Okazaki M. Hepatocellular carcinoma after transcatheter hepatic arterial embolization. A histopathologic study of 84 resected cases. Cancer 1994;73:2259-67.
5. Ng IOL, Lai ECS, Fan ST, NgM, Chan ASY, So MKP. Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma. Cancer 1994;73:2268-74.
6. Isobe H, Imari Y, Sakai H, Sakamoto S, Nawata H. Subcutaneous seeding of hepatocellular carcinoma following fineneedle aspiration biopsy. J Clin Gastroenterol 1993;17:350-2.
7. Nakamuta M, Tanabe Y, Ohashi M, Yoshida K, Hiroshige K, Nawata H. Transabdominal seeding of hepatocellular carcinoma after fine-needle aspiration biopsy. J Clin Ultrasound 1993;21:551-6.
8. Edmondson HA, Steiner PE. Primary carcinoma of the liver. A study of 100 cases among 48,900 necropsies. Cancer 1954;7:462-503.
9. Mathews MB, Bernstein RM, Franza BR, Garrels JI, Identity of the proliferating cell nuclear antigen and cyclin. Nature 1984;309:374-6.
10. Bravo R, Frank R, Blundell PA, MacDonald-Bravo H. Cyclin/ PCNA is the auxiliary protein of DNA polymerase-α. Nature 1987;326:515-7.
11. Linden MD, Torres FX, Kubus J, Zarbo RJ. Clinical application of morphologic and immunocytochemical assessments of cell proliferation. Am J Clin Pathol 1992;97:4S-13S.
12. Hall PA, Levison DA, Woods AL, Yu CC-W, Kellock DB, Watkins JA, et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 1990;162:285-94.
13. Taylor CR, Shi S-R, Chaiwun B, Young L, Imam A, Cote RJ. Strategies for improving the immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections: androgen receptor, estrogen receptor, progesterone receptor, p53 protein, proliferating cell nuclear antigen, and Ki-67 antigen revealed by antigen retrieval techniques. Hum Pathol 1994;25:263-70.
14. Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 1985;56:918-28.
15. Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire. A comparison of Iipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med 1995;332:1256-61.
16. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations J Am Star Assoc 1958;53:457-81.
17. Cox DR. Regression models and life tables [with discussion]. J R Stat Soc [B] 1972;34:187-220.
18. Quinn CM, Wright NA. The clinical assessment of proliferation and growth in human rumours: evaluation of methods and applications as prognostic variables. J Pathol 1990;160:93-9.
19. Hilsenbeck SG, Allred DC. Improved methods of estimating mitotic activity in solid tumors. Hum Pathol 1992;23:601-2.
20. Tarao K, Shimizu A, Harada M, Ohkawa S, Okamoto N, Kuni Y, et al. In vitro uptake of bromodeoxyuridine by human hepatocellular carcinoma and its relation to histopathologic findings and biologic behavior. Cancer 1991;68:1789-94.
21. Melchiorri C, Bolondi L, Chieco P, Pagnoni M, Gramantieri L, Barbara L. Diagnostic and prognostic value of DNA ploidy and cell nuclearity in ultrasound-guided liver biopsies. Cancer 1994;74:1713-9.
22. Okada S, Shimada K, Yamamoto J, Takayama T, Kosuge T, Yamasaki S, et al. Predictive factors for postoperative recurrence of hepatocellular carcinoma. Gastroenterology 1994;106:1618-24.
23. Cattoretti G, Becker MH, Key G, Duchrow M, Schlüter C, Galle J, et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992;168:357-63.
24. OJanguren I, Ariza A, Llatjos M, Castella E, Mate JL, NavasPalacios JJ. Proliferating cell nuclear antigen expression in normal, regenerative, and neoplastic liver: a fine-needle aspiration cytology and biopsy study. Human Pathol 1993;24:905-8.
25. Taniai M, Tomimatsu M, Okuda H, Saito A, Obata H. Immunohistochemical detection of proliferating cell nuclear antigen in hepatocellular carcinoma: relationship to histological grade. J Gastroenterol Hepatol 1993;8:420-5.
26. Terada T, Nakanuma Y. Cell proliferative activity in adenomatous hyperplasia of the liver and small hepatocellular carcinoma. An immunohistochemical study demonstrating proliferating cell nuciear antigen. Cancer 1992;70:591-8.
27. Nakajima T, Kagawa K, Ueda K, Ohkawara T, Kimura H, Kakusui M, et al. Evaluation of hepatic proliferative activity in chronic liver diseases and hepatocellular carcinomas by proliferating cell nuclear antigen (PCNA) immunohistochemical staining of methanol-fixed tissues. J Gastroenterol 1994;29:450-4.
28. Nishimori H, Tsukishiro T, Nambu S, Okada K, Shimizu Y, Miyabayashi C, et al. Analyses of proliferating cell nuclear antigen-positive cells in hepatocellular carcinoma: comparisons with clinical findings. J Gastroenterol Hepatol 1994;9:425-32.
29. Patriarca C, Roncalli M, Gambacorta M, Cominotti M, Coggi G, Viale G. Patterns of integrin common chain β1 and collagen IV immunoreactivity in hepatocellular carcinoma. Correlations with tumor growth rate, grade and size. J Hepatol 1993;171:5-11.
30. Suehiro T, Matsumata T, Itasaka H, Yamamoto K, Kawahara N, Sugimachi K. Clinicopathologic features and prognosis of resected hepatocellular carcinomas of varied sizes with special reference to proliferating cell nuclear antigen. Cancer 1995;76:399-405.
31. AL-Sheneber IF, Shibata HR, Sampalis J, Jothy S. Prognostic significance of proliferating cell nuclear antigen expression in colorectal cancer. Cancer 1993;71:1954-9.
32. Mayer A, Takimoto M, Fritz E, Schellander G, Kofler K, Ludwig H. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer 1993;71:2454-60.
33. Yonemura Y, Kimura H, Fushida S, Tugawa K, Nakai Y, Kaji M, et al. Analysis of proliferative activity using anti-proliferating cell nuclear antigen antibody in gastric cancer tissue specimens obtained by endoscopic biopsy. Cancer 1993; 71:2448-53.
34. Tanaka M, Omura K, Oda Y, Nakanishi I. Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity. J Surg Oncol 1994;57:57-64.
35. Mangham DC, Rowlands DC, Newbold KM, Reynolds GM, Fielding JW, Hallissey MT. Expression of proliferating cell nuclear antigen (PCNA) in gastric carcinoma: no evidence for prognostic value. J Clin Pathol 1994;47:473-4.
36. McCormick D, Hall PA. The complexities of proliferating cell nuclear antigen. Histopathology 1992;21:591-4.
37. Galand P, Degraef C. Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labelling for marking S phase cells in paraffin sections from animal and human tissues. Cell Tissue Kinet 1989;22:383-92.
38. Celis JE, Celis A. Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase, Proc Natl Acad Sci USA 1985;82:3262-6.
39. Mancini R, Marucci L, Benedetti A, Jezequel AM, Orlandi F. Immunohistochemical analysis of S-phase cells in normal human and rat liver by PC10 monoclonal antibody. Liver 1994;14:57-64.
40. Hall PA, Coates PJ, Goodlad RA, Hart IR, Lane DP. Proliferating cell nuclear antigen expression in non-cycling cells may be induced by growth factors in vivo. Br J Cancer 1994;70:244-7.
41. Dervan PA, Magee HM, Buckley C, Carney DN. Proliferating cell nuclear antigen counts in formalin-fixed paraffin-embedded tissue correlate with Ki-67 in fresh tissue. Am J Clin Pathol 1992;97:21S-8S.
42. Garcia RL, Coltrera MD, Gown AM. Analysis of proliferative grade using anti-PCNA/Cyclin monoclonal antibodies in fixed, embedded tissues. Comparison with flow cytometric analysis. Am J Pathol 1989;134:733-9.
43. Harrison RF, Reynolds GM, Rowlands DC. Immunohistochemical evidence for the expression of proliferating cell nuclear antigen (PCNA) by non-proliferating hepatocytes adjacent to metastatic tumours and in inflammatory conditions. J Pathol 1993;171:115-22.
44. Sabattini E, Gerdes J, Gherlinzoni F, Poggi S, Zucchini L, Melilli G, et al. Comparison between the monoclonal antibodies Ki-67 and PC10 in 125 malignant lymphomas. J Pathol 1993;169:397-403.
45. Lynch DAF, Clarke AMT, Jackson P, Axon ATR, Dixon MF, Quirke P. Comparison of labelling by bromodeoxyuridine, MIB-1, and proliferating cell nuclear antigen in gastric mucosal biopsy specimens. J Clin Pathol 1994;47:122-5.
46. Benjamin DR. Gown AM. Aberrant cytoplasmic expression of cell nuclear antigen in hodgkin's disease. Am J Surg Pathol 1991;15:764-8.
47. Koukoulis G, Rayner A, Tan K-C, Williams R, Portmann B. Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining. J Pathol 1992;166:359-68.
48. Burford-Mason AP, Mackay AJ, Cummins M, Dardick I. Detection of proliferating cell nuclear antigen in paraffin-embedded specimens is dependent on preembedding tissue handling and fixation. Arch Pathol Lab Med 1994;118:1007-13.
49. Weidner N, Moore DH, Ljung BM, Waldman FM, Goodson WH, Mayall B, et al. Correlation of bromodeoxyuridine (BRDU) labeling of breast carcinoma cells with mitotic figure content and tumor grade. Am J Surg Pathol 1993;17:987-94.
50. Weidner N, Moore DH, Vartanian R. Correlation of Ki-67 antigen expression with mitotic figure index and tumor grade in breast carcinomas using the novel "paraffin"-reactive MlB1 antibody. Hum Pathol 1994;25:337-42.
51. Van Diest PJ, Baak PA, Matze-Cok P, Wisse-Brekelmans ECM, Van Galen CM, Kurver PHJ, et al. Reproducibility of mitosis counting in 2,469 breast cancer specimens: results from the Multicenter Morphometric mammary carcinoma project. Hum Pathol 1992;23:603-7.
52. Stevens WR, Johnson CD, Stephens DH, Batts KP. CT findings in hepatocellular carcinoma: correlation of tumor characteristics with causative factors, tumor size, and histologic tumor grade. Radiology 1994;191:531-7.
53. Ikeda K, Saitoh S, Tsubota A, Arase Y, Chayama K, Kumada H, et al. Risk factors for tumor recurrence and prognosis after curative resection of hepatocellular carcinoma. Cancer 1993;71:19-25.
54. Torii A, Nonami T, Harada A, Yasui M, Nakao A, Takagi H. Extent of hepatic resection as a prognostic factor for small, solitary hepatocellular carcinomas. J Surg Oncol 1993;54:13-7.
55. Nzeako UC, Goodman ZD, Ishak KG. Comparison of tumor pathology with duration of survival of North American patients with hepatocellular carcinoma. Cancer 1995;76:579-88
56. Lai ECS, Ng IOL, Ng MMT, Lok ASF, Tam PC, Fan ST, et al. Long-term results of resection for large hepatocellular carcinoma: a multivariate analysis of clinicopathological features. Hepatology 1990;11:815-8.
57. Arii S, Tanaka J, Yamazoe Y, Minematsu S, Morino T, Fujita K, et al. Predictive factors for intrahepatic recurrence of hepatocellular carcinoma after partial hepatectomy. Cancer 1992;69:913-9.
58. The Liver Cancer Study Group of Japan. Predictive factors for long term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. Cancer 1994;74:2772-80.
59. Izumi R, Shimizu K, II T, Yagi M, Matsui O, Nonomura A, et al. Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection. Gastroenterology 1994;106:720-7.
60. Vauthey JN, Klimstra D, Blumgart LH. A simplified staging system for hepatocellular carcinomas. Gastroenterology 1995;108:617-8.
61. Calvet X, Bruix J, Gines P, Bru C, Sole M, Vilana R, et al. Prognostic factors of hepatocellular carcinoma in the West: a multivariate analysis in 206 patients. Hepatology 1990;12:753-60.