Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 2, 1996, Pages 109-117

  Takemura, Yuzuru ^a   Gibson, William ^c   Kimbell, Rosemary ^c   Kobayashi, Hiroyuki ^a   Miyachi, Hayato ^b   Jackman, Ann L ^c  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b TOKAI UNIVERSITY   (Japan)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Acquired resistance; Cellular pharmacokinetics; Drug sensitivity; Polyglutamation; ZD1694

Indexed keywords

ANTINEOPLASTIC AGENT; RALTITREXED;

ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SENSITIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PHARMACOKINETICS; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FOLIC ACID; HUMANS; INTRACELLULAR FLUID; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOID, CHRONIC; POLYGLUTAMIC ACID; QUINAZOLINES; TETRAHYDROFOLATE DEHYDROGENASE; THIOPHENES; THYMIDYLATE SYNTHASE; TRITIUM; TUMOR CELLS, CULTURED;

EID: 0030046343     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01226268     Document Type: Article

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