Suppression of the human immunodeficiency virus long terminal repeat by CD8+ T cells is dependent on the NFAT-1 element

AIDS Research and Human Retroviruses

Volumn 12, Issue 2, 1996, Pages 143-148

  Copeland, Karen F T ^a   McKay, Paula J ^a   Rosenthal, Kenneth L ^a  

^a MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IONOMYCIN; MITOGENIC AGENT; NUCLEAR FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR SP1;

ARTICLE; CONTROLLED STUDY; HERPES VIRUS SAIMIRI; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONG TERMINAL REPEAT; MUTAGENESIS; PRIORITY JOURNAL; SUPERNATANT; T LYMPHOCYTE SUBPOPULATION; TRANSACTIVATION;

EID: 0030045909     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1996.12.143     Document Type: Article

References (33)

1. + lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 1986;234:1563-1566.
2. + cells from infected and uninfected chimpanzees. Cell Immunol 1991; 132:246-255.
3. Ennen J, Findekelle H, Dittmar MT, Norley S, Ernst M, and Kurth R: CD8+ T lymphocytes of African green monkeys secrete an immunodeficiency virus-suppressing lymphokine. Proc Natl Acad Sci USA 1994;91:7207-7211.
4. Husch B, Eibl MM, and Mannhalter JW: CD3, CD8 double-positive cells from HIV-1-infected chimpanzees show group-specific inhibition of HIV-1 replication. AIDS Res Hum Retroviruses 1993;9:405-413.
5. Powell JD, Bednarik DP, Folks TM, Jehuda-Cohen T, Villinger F, Sell KW, and Ansari AA: Inhibition of cellular activation of retroviral replication by CD8+ T cells derived from nonhuman primates. Clin Exp Immunol 1993;91:473-481.
6. Brinchmann JE, Gaudernack G, and Vandal F: CD8+ T cells inhibit HIV replication in naturally infected CD4+ T cells: evidence for a soluble inhibitor. J Immunol 1990;144:2961-2966.
7. Walker CM and Levy JA: A diffusable lymphokine produced by CD8+ T lymphocytes suppresses HIV replication. Immunology 1989;66:628-630.
8. Brinchmann JE, Gaudernack G, and Vartdal F: In vitro replication of HIV-1 in naturally infected CD4+ T cells is inhibited by rIFNa2 and by a soluble factor secreted by CD8+ activated CD8+ T cells, but not by rIFBb, rIFNg or recombinant tumor necrosis factor-a. J Acquir Immun Defic Syndr 1991;4:480-488.
9. Mackewicz CE, Ortega HW, and Levy JA: CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual. J Clin Invest 1991;87:1462-1466.
10. + T cell phenotype correlates with anti-HIV activity and asymptomatic clinical status. Clin Immunol Immunopathol 1993;69:106-116.
11. + T cells correlates with CD4 counts and clinical stage of disease. Clin Exp Immunol 1994;97:68-75.
12. Chen C-H, Weinhold KJ, Bartlett JA, Bolognesi DP, and Greenberg M: CD8+ T lymphocyte-mediated inhibition of HIV-1 long terminal repeat transcription: A novel antiviral mechanism. AIDS Res Hum Retroviruses 1993;9:1079-1086.
13. + cells from non-human primates. J AIDS 1994;7:438-446.
14. + T cells suppress human immunodeficiency virus replication by inhibiting viral transcription. Proc Natl Acad Sci USA 1995;92:2308-2312.
15. + T cells is not lentivirus specific. AIDS Res Hum Retroviruses 1995;11:1321-1326.
16. Biesinger B, Muller-Fleckenstein I, Simmer B, Lang G, Wittmann S, Platzer E, Desrosiers RC, and Fleckenstein B: Stable growth transformation of human T lymphocytes by Herpesvirus saimiri. Proc Natl Acad Sci USA 1992;89:3116-3119.
17. Berkhout B, Silverman RH, and Jeang K-T: Tat trans-activates the human immunodeficiency virus through a nascent RNA target. Cell 1989;59:273-282.
18. Pierce JW, Lenardo M, and Baltimore D: Oligonucleotide that binds nuclear factor NFκB acts as a lymphoid-specific and inducible enhancer element. Proc Natl Acad Sci USA 1988;85: 1482-1486.
19. Leonard J, Parrott C, Buckler-White AJ, Turner W, Ross EK, Martin MA, and Rabson AB: The NF-κB binding sites in the human immunodeficiency virus type 1 long terminal repeat are not required for virus infectivity. J Virol 1989;63:4919-4924.
20. Berkhout B, Gatignol A, Silver J, and Jeang K-T: Efficient trans-activation by the HIV-1 Tat protein requires a duplicated TAR RNA structure. Nucleic Acids Res 1990;18:1839-1846.
21. Markovitz DM, Hannibal MC, Smith MJ, Cossman R, and Nabel GJ: Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1. J Virol 1992;66:3961-3965.
22. Queen C and Baltimore D: Immunoglobulin gene transcription is activated by downstream sequence elements. Cell 1983;33: 741-748.
23. Herbomel P, Bourachof B, and Yaniv M: Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. Cell 1984;39:653-661.
24. Berkhout B, Gatignol A, Rabson AB, and Jeang K-T: TAR-independent activation of the HIV-1 LTR: Evidence that Tat requires specific regions of the promoter. Cell 1990;62:757-767.
25. Berkhout B and Jeang K-T: Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat. J Virol 1992;66:139-149.
26. Harrich D, Garcia J, Wu F, Mitsuyasu R, and Gaynor R: Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat. J Virol 1989;63:2585-2591.
27. Siekevitz M, Josephs SF, Dukovich M, Peffer N, Wong-Staal F, and Greene WC: Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-1. Science 1987;238: 1575-1578.
28. Lu Y, Touzjian N, Stenzel M, Dorfman T, Sodroski JG, and Haseltine WA: Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1. J Virol 1990;64:5226-5229.
29. Jeang K-T, Chun R, Lin NH, Gatignol A, Glabe G, and Fan H: In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. J Virol 1993;67: 6224-6233.
30. Kashanchi F, Piras G, Radonovich MF, Duvall JF, Fattaey A, Chiang C-M, Roeder RG, and Brady JN: Direct interaction of human TFIID with the HIV-1 trans activator tat. Nature (London) 1994;367:295-299.
31. Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, and Gulino A: Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif. Biochem Biophys Res Commun 1994; 205:467-474.
32. Schmidt A, Hennighausen L, and Siebenlist U: Inducible nuclear factor binding to the κB elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner. J Virol 1990;64:4037-4041.
33. Emmel EA, Verweij CL, Durand DB, Higgins KM, and Lacy E and Crabtree GR: Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 1989;24:1617-1620.