Renal enlargement and insulin-like growth factor-1 accumulation in the Wistar rat model of experimental diabetes is not prevented by angiotensin converting enzyme inhibition

Diabetologia

Volumn 39, Issue 2, 1996, Pages 166-171

  New, J P ^a,e   Canavan, J P ^a   Flyvbjerg, A ^b   Hamon, G ^c   Bilous, R W ^d   Marshall, S M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b AARHUS UNIVERSITY   (Denmark)

^c SANOFI   (France)

^d JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

^e ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Angiotensin; Angiotensin II; Converting enzyme inhibition; Insulin like growth factor 1; Renal enlargement; Renal haemodynamics,

Indexed keywords

ANGIOTENSIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INSULIN ZINC SUSPENSION; PLACEBO; SOMATOMEDIN C; TRANDOLAPRIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; KIDNEY BLOOD FLOW; KIDNEY HYPERTROPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; SUBCUTANEOUS DRUG ADMINISTRATION;

ANALYSIS OF VARIANCE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; INSULIN; INSULIN-LIKE GROWTH FACTOR I; KIDNEY; MALE; ORGAN SIZE; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, WISTAR; RENIN;

EID: 0030045869     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00403959     Document Type: Article

References (28)

1. Hostetter TH, Rennke HG, Brenner BM (1982) The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies. Am J Med 72: 375-380
2. Zatz R, Brenner BM (1986) Pathogenesis of diabetic microangiopathy. The haemodynamic view. Am J Med 80: 443-453
3. Zatz R, Meyer T, Rennke H, Brenner BM (1985) Predominance of haemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy. Proc Natl Acad Sci USA 82: 5963-5967
4. Hostetter TH, Troy JL, Brenner BM (1981) Glomerular haemodynamics in experimental diabetes. Kidney Int 19: 410-415
5. Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM (1981) Hyperfiltration in remnant nephrons: a potential adverse response to renal ablation. Am J Physiol 241:F85-F93
6. Flyvbjerg A, Thorlacius-Ussing O, Naeraa R, Ingerslev J, Ørskov H (1988) Kidney tissue somatomedin C and initial renal growth in diabetic and uninephrectomised rats. Diabetologia 31: 310-314
7. Flyvbjerg A, Bornfeldt KE, Marshall SM, Arnqvist HJ, Ørskov H (1990) Kidney IGF-1 mRNA in initial renal hypertrophy in experimental diabetes in rats. Diabetologia 33: 334-338
8. Hirschberg R, Kopple JD (1989) Evidence that insulin-like growth factor 1 increases renal plasma flow and glomerular filtration rate in fasted rats. J Clin Invest 83: 326-330
9. Hirschberg R, Kopple JD, Blantz R, Tucker B (1991) Effects of recombinant human insulin-like growth factor on glomerular dynamics in the rat. J Clin Invest 87: 1200-1206
10. Guler HP, Schmid C, Zapf J, Froesch ER (1989) Effects of recombinant insulin-like growth factor 1 on insulin secretion and renal function in normal human subjects. Proc Natl Acad Sci USA 86: 2868-2872
11. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Porcine measurements with the folin phenol reagents. J Biol Chem 193: 265-275
12. Chevillard C, Saavedra JM (1982) Distribution of angiotensin converting enzyme activity in specific areas of the rat brain stem. J Neurochem 38: 281-284
13. Anderson S, Rennke H, Garcia D, Brenner BM (1989) Short and long term antihypertensive therapy in the diabetic rat. Kidney Int 36: 526-536
14. Anderson S, Rennke HG, Brenner BM (1986) In arresting renal disease, all anti-hypertensive drugs are not created equal. Kidney Int 29: 314 (Abstract)
15. Zatz R, Dunn BR, Meyer TW, Anderson S, Rennke HG, Brenner BM (1986) Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension. J Clin Invest 77: 1925-1930
16. Seyer-Hansen K (1976) Renal hypertrophy in streptozotocin-diabetic rats. Clin Sci 51: 551-555
17. Seyer-Hansen K (1977) Renal hypertrophy in experimental diabetes: relation to severity of diabetes. Diabetologia 13: 141-143
18. Seyer-Hansen K (1983) Renal hypertrophy in experimental diabetes. Kidney Int 23: 643-646
19. Rasch R (1979) Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment. Diabetologia 16: 319-324
20. Rasch R (1984) Tubular lesions in streptozotocin-diabetic rats. Diabetologia 27: 32-37
21. Cortes P, Dumler F, Goldman J, Lewin NW (1987) Relationship between renal function and metabolic alterations in early streptozotocin-induced diabetes in rats. Diabetes 36: 80-87
22. 3H-thymidine uptake in diabetic and uninephrectomized rats. Diabetologia 25: 280-287
23. Flyvbjerg A, Bornfeldt KE, Ørskov H, Arnqvist HJ (1991) Effect of insulin-like growth factor 1 infusion on renal hypertrophy in experimental diabetes mellitus in rats. Diabetologia 34: 715-720
24. Flyvbjerg A, Marshall SM, Frystyk J, Hansen KW, Harris AG, Ørskov H (1992) Octreotide administration in diabetic rats: effects on kidney growth and urinary albumin excretion. Kidney Int 41: 805-812
25. Lever AF (1986) Slow pressor mechanisms in hypertension: a role for hypertrophy of resistance vessels? J Hypertension 4: 515-524
26. + pump activity in cultures of smooth muscle from rat aorta. Proc Natl Acad Sci USA 79: 1438-1442
27. Cooper ME, Allen TJ, Clarke BE, Jerums G, Doyle AE (1989) Enalapril retards glomerular basement thickening and albuminuria in the diabetic rat. Diabetologia 32: 326-328
28. O'Brian R, Cooper ME, Jerums G, Doyle AE (1993) The effects of perindopril and triple therapy in a normotensive model of diabetic nephropathy. Diabetes 42: 604-609