Intratumor administration of fusogenic liposomes containing fragment A of diphtheria toxin suppresses tumor growth

Cancer Letters

Volumn 100, Issue 1-2, 1996, Pages 63-69

  Mizuguchi, Hiroyuki ^a   Nakanishi, Tsuyoshi ^a   Nakanishi, Mahito ^b,c   Nakagawa, Tetsuhiko ^a   Nakagawa, Shinsaku ^a   Mayumi, Tadanori ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Fragment A of diphtheria toxin; Fusogenic liposome; Intratumor; Sarcoma 180; Sendai virus

Indexed keywords

ANTINEOPLASTIC AGENT; DIPHTHERIA TOXIN; INULIN; LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; INTRATUMORAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOMA 180; SENDAI VIRUS; SOLID TUMOR; SURVIVAL TIME; TUMOR GROWTH; TUMOR VOLUME;

EID: 0030045159     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(95)04081-1     Document Type: Article

References (21)

1. Asher, A.L, Mule, J.J., Kasid, A., Restifo, N.P., Salo, J.C., Reichert, CM., Jaffe, G., Fendly, B., Kriegler, M. and Rosenberg, S.A. (1991) Murine tumor cells transduced with the gene for tumor necrosis factor-α: evidence for paracrine immune effects of tumor necrosis factor against tumors. J. Immunol., 146, 3227-3234.
2. Bonhomme, L., Mathieu, M.C., Amdidouche, D., Faure, E., Guisteau, D., Fredj, G. and Naveau, S. (1992) Intratumor treatment of C3H mouse mammary carcinoma with 5-fluorouracil adsorbed on activated charcoal particles. Anti-Cancer Drugs, 3, 261-266.
3. Carroll, S.F. and Collier, R.J. (1988) Diphtheria toxin: quantification and assay. Methods Enzymol., 165, 218-225.
4. Dehouck, M.-P., Meresse, S., Delorme, P., Fruchart, J.-C. and Cecchelli, R. (1990) An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro. J. Neurochem., 54, 1798-1801.
5. Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D. and Mulligan, R.C. (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA, 90, 3539-3543.
6. Golumbek, P.T., Lazenby, A.J., Levitsky, H.I., Jaffee, L.M., Karasuyama, H., Baker, M. and Pardoll, D.M. (1991) Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science, 254, 713-716.
7. Kato, K., Nakanishi, M., Kaneda, Y., Uchida, T. and Okada, Y. (1991) Expression of Hepatitis B virus surface antigen in adult rat liver. J. Biol. Chem., 266, 3361-3364.
8. Kato, K., Kaneda, Y., Sakurai, M. Nakanishi, M. and Okada, Y. (1991) Direct injection of Hepatitis B virus DNA into liver induced Hepatitis in adult rats. J. Biol. Chem., 266, 22071-22074.
9. Maeda, H., Seymour, L.W. and Miyamoto, Y. (1992) Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo. Bioconjugate Chem., 3, 351-334.
10. Mizuguchi, H., Nakanishi, M., Nakanishi, T., Nakagawa, T., Nakagawa, S. and Mayumi, T., Application of fusogenic liposomes containing fragment A of diphtheria toxin to cancer therapy. Br. J. Cancer, in press.
11. Nabel, G.J., Nabel, E.G., Yang, Z-Y., Fox, B.A., Plautz, G.E., Gao, X., Huang, L., Shu, S., Gordon, D. and Chang, A.E. (1993) Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc. Natl. Acad. Sci. USA, 90, 11307-11311.
12. Nakanishi, M., Uchida, T., Sugawa, H., Ishiura, M. and Okada, Y. (1985) Efficient introduction of contents of liposomes into cells using HVJ (Sendai virus). Exp. Cell Res., 159, 399-409.
13. Nakanishi, M. and Okada, Y. (1993) Liposome-mediated introduction of macromolecules into living animal cells with the aid of HVJ (Sendai virus). In: Liposome Technology, pp. 249-260. Editors: G. Gregoriadis. CRC Press, Boca Raton, FL.
14. Nakanishi, M., Ashihara, K., Senda, T., Kondo, T., Kato, K. and Mayumi, T. (1995) Gene introduction into animal tissues. In: Trends and Future Perspectives in Peptide and Protein Drug Delivery, pp. 337-349. Editors: V.H.L. Lee, M. Hashida and Y. Mizushima. Harwood, The Netherlands.
15. Plautz, G.E., Yang, Z.-Y., Wu, B.-Y., Gao, X., Huang, L. and Nabel, G.J. (1993) Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc. Natl. Acad. Sci. USA, 90, 4645-4649.
16. Szoka, F. and Papahadjopoulos, D. (1978) Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc. Natl. Acad. Sci. USA, 75, 4194-4198.
17. Takamatsu, K., Uchida, T. and Okada, Y. (1986) Specific purification of elongation factor 2 and isolation of its anti-body. Biochem. Biophys. Res. Commun., 134, 1015-1021.
18. Uchida, T. (1981) Diphtheria toxin; biological activity. In: Molecular Action of Toxins and Viruses, pp. 1-31. Editors: P. Cohen and S.V. Heyningen. Elsevier, Amsterdam.
19. Uchida, T., Kim, J., Yamaizumi, M., Miyake, Y. and Okada, Y. (1979) Reconstitution of lipid vesicles associated with HVJ (Sendai virus spikes). Purification and some properties of vesicles containing non-toxic fragment A of diphtheria toxin. J. Cell Biol., 80, 10-20.
20. Wawrzynczak, E.J. (1991). Systemic immunotoxin therapy of cancer: advances and prospects. Br. J. Cancer, 64, 624-630.
21. Yamaizumi, M., Mekada, E., Uchida, T. and Okada, Y. (1978) One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell, 15, 245-250.