Clinical trials

Seminars in Surgical Oncology

Volumn 12, Issue 1, 1996, Pages 32-38

  Blichert Toft, Mogens ^a   Mouridsen, Henning ^a   Andersen, Knud West ^a  

^a Rigshospitalet   (Denmark)

Author keywords

cancer therapy; clinical research; informed consent; patient denial; randomized trial

Indexed keywords

CYCLOPHOSPHAMIDE; EPIRUBICIN; ESTROGEN RECEPTOR; FLUOROURACIL; METHOTREXATE; PAMIDRONIC ACID; PREDNISOLONE; TAMOXIFEN;

BREAST CANCER; CANCER RADIOTHERAPY; CASTRATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENMARK; FEMALE; HUMAN; INFORMED CONSENT; MAJOR CLINICAL STUDY; MASTECTOMY; MEDICAL DECISION MAKING; ORAL DRUG ADMINISTRATION; OVARIECTOMY; PARTIAL MASTECTOMY; PATIENT SELECTION; PHYSICIAN ATTITUDE; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; TREATMENT OUTCOME;

EID: 0030044829     PISSN: 87560437     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2388(199601/02)12:1<32::AID-SSU5>3.3.CO;2-C     Document Type: Review

References (24)

1. Buyse M: Randomized clinical trials in surgical oncology. Eur J Surg Oncol 17:421-421, 1991.
2. Fisher BF: Clinical trials for the evaluation of cancer therapy. Cancer 54:2609-2617, 1984.
3. Fischerman K, Mouridsen HT: Danish Breast Cancer Cooperative Group (DBCG). Structure and results of the organization. Acta Oncol 27.593-596, 1988.
4. Gillon R: Conscience, good character, integrity, and to hell with philosophical medical ethics? BMJ 290:1497-1498, 1985.
5. Fisher B: On clinical trial participation. J Clin Oncol 9:1927-1930, 1991.
6. Medical Research Council: Streptomycin treatment of pulmonary tuberculosis. BMJ 2:769-782, 1948.
7. Early Breast Cancer Trialists Collaborative Group: Systemic treatment of early breast cancer by hormonal, cytotoxic, or immunotherapy. Lancet 339:1-15, 71-85, 1992.
8. Pocock SJ: "Clinical trials. A Practical Approach." Chichester: John Wiley & Sons, 1990.
9. Lawrence W Jr: Some problems with clinical trials. Arch Surg 126:370-378, 1991.
10. Baum M: New approach for recruitment into randomized controlled trials. Lancet 341:812-813, 1993.
11. Machin D, Cambell MJ: "Statistical Tables for the Design of Clinical Trials." Oxford: Blackwell Scientific. 1987.
12. Cancer Research Campaign: Informed consent: Ethical, legal, and medical implications for doctors and patients who participate in randomized clinical trials. BMJ 286:1117-1121, 1983.
13. Benson III AB, Pregler JP, Bean JA, et al: Oncologists' reluctance to accrue patients onto clinical trials: An Illinois cancer center study. J Clin Oncol 9:2067-2075, 1991.
14. Zelen M: Randomized consent designs for clinical trials: An update. Stat Med 9:645-656, 1990.
15. Status for DBCG-77 and DBCG-82 trials: DBCG Newsl 26:4-10, 1993.
16. Status for DBCG-89 trials: DBCG Newsl 27:4-7, 1994.
17. Jack W JL, Chetty U, Rodger A: Recruitment to a prospective breast conservation trial: Why are so few patients randomized? BMJ 301:83-85, 1990.
18. Blichert-Toft M, Rose C, Andersen JA, et al: Danish randomized trial comparing breast conservation therapy with mastectomy Six years of life-table analysis. J Natl Cancer Inst Monogr 11:19-25, 1992.
19. Linden WVD: Pitfalls in randomized surgical trials. Surgery 87:258-262, 1980.
20. Van Dongen JA Early breast cancer. A review. Acta Oncol 28:123-134, 1989.
21. Angell M: Patients' preference in randomized clinical trials. N Engl J Med 310:1385-1387, 1984.
22. Taylor KM, Margolese RG, Soskolne CL: Physicians' reasons for not entering eligible patients in a randomized clinical trial of surgery for breast cancer. N Engl J Med 310:1363-1367, 1984.
23. Balch CM, Durant JR, Bartolucci AA, Southeastern Cancer Study Group: The impact of surgical quality control in multiinstitutional group trials involving adjuvant cancer treatments. Ann Surg 198:164-167, 1983.
24. Andreasen AH, Mouridsen HT, Andersen KW, et al: Equity and improvement in outcome of breast cancer in Denmark, In France FHR, van Goor JN, Johansen KS (eds): "Case-Based Telematic Systems." Amsterdam: IOS Press, 1994, 27-38.