Thyrotropin (TSH)-Releasing Hormone Stimulates TSHβ Promoter Activity by Two Distinct Mechanisms Involving Calcium Influx Through L Type Ca2+ Channels and Protein Kinase C

Molecular Endocrinology

Volumn 10, Issue 1, 1996, Pages 90-99

  Shupnik, Margaret A ^a,c   Week, Jennifer ^a   Hinkle, Patricia M ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; NIMODIPINE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; THYROTROPIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; DNA FLANKING REGION; DNA SEQUENCE; ENZYME ACTIVITY; EXTRACELLULAR CALCIUM; GENE EXPRESSION; GENETIC TRANSCRIPTION; HORMONAL REGULATION; HORMONE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; CALCIUM; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL LINE; EMBRYO; ENZYME ACTIVATION; HUMANS; KIDNEY; NIMODIPINE; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; RATS; TETRADECANOYLPHORBOL ACETATE; THYROTROPIN; THYROTROPIN-RELEASING HORMONE; TRANSFECTION;

EID: 0030044755     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.10.1.8838148     Document Type: Article

References (46)

1. Shupnik MA, Ridgway EC, Chin WW 1989 Molecular biology of thyrotropin. Endocr Rev 10:459-475
2. Staub RE, Frech GC, Joho RH, Gershengorn MC 1990 Expression cloning of a cDNA encoding the mouse pituitary thyrotropin releasing hormone receptor. Proc Natl Acad Sci USA 97:9514-9518
3. Hinkle PM 1989 Pituitary thyrotropin-releasing hormone receptors. In: Metcalf G, Jackson IMD (eds) Thyrotropin-Releasing Hormone: Biomedical Significance. Ann NY Acad Sci 553:176-187
4. 2+ concentrations to hormone secretion. Selection blockage using ionomycin and nifedipine. J Biol Chem 259:15350-15363
5. 3 cell membranes is GTP dependent but insensitive to cholera or pertussis toxin. J Biol Chem 261:10141-10149
6. 2+ channels specifically regulate prolactin production by GH4C1 pituitary tumor cells. J Biol Chem 262:3154-3159
7. Shupnik MA, Greenspan SL, Ridgway EC 1986 Transcriptional regulation of thyrotropin subunit genes by thyrotropin releasing hormone and dopamine in pituitary cell culture. J Biol Chem 261:12675-12679
8. Elsholtz HP, Mangalam HJ, Potter E, Albert VR, Supowit S, Evans RM, Rosenfeld MG 1986 Two different cis-active elements transfer the transcriptional effect of both EGF and phorbol esters. Science 234:1552-1557
9. Shupnik MA, Rosenzweig BA, Friend KE, Mason ME 1992 Thyrotropin (TSH)-releasing hormone-responsive elements in the rat TSHβ gene have distinct biological and nuclear protein-binding properties. Mol Endocrinol 6:43-53
10. Kim DS, Ahn SK, Yoon JH, Hong SH, Kim KE, Maurer RA, Park SD 1994 Involvement of a cAMP-responsive DNA element in mediating TRH responsiveness of the human thyrotropin alpha-subunit gene. Mol Endocrinol 8:529-536
11. Day RN, Maurer RA 1990 Pituitary calcium channel modulation and regulation of prolactin gene expression. Mol Endocrinol 4:736-742
12. Yan G-Z, Bancroft C 1991 Mediation by calcium of thyrotropin-releasing hormone action on the prolactin promoter via transcription factor pit-1. Mol Endocrinol 5:1488-1497
13. Mason ME, Friend KE, Copper J, Shupnik MA 1993 Pit-1/GHF-1 binds to TRH-sensitive regions of the rat thyrotropin β gene. Biochemistry 32:8932-8938
14. Steinfelder HJ, Hauser P, Nakayama Y, Radovick S, McClasky JH, Taylor T, Weintraub BD, Wondisford FE 1991 Thyrotropin-releasing hormone regulation of human TSHβ expression: role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid-hormone inhibitory element. Proc Natl Acad Sci USA 88:3130-3134
15. Li P, Thaw CN, Sempowski GD, Gershengorn MC, Hinkle PM 1992 Characterization of the calcium response to TRH in cells transfected with TRH receptor DNA: importance of voltage sensitive calcium channels. Mol Endocrinol 6:1393-1402
16. 2+ from an intracellular store in GH4C1 cells. Biochem J 267:359-364
17. Carr FE, Galloway RJ, Reid AH, Kaseem LK, Shillon G, Fein HG, Smallridge RC 1991 Thyrotropin-releasing hormone regulation of thyrotropin β-subunit gene expression involves intracellular calcium and protein kinase C. Biochemistry 30:3721-3728
18. Shupnik MA, Rosenzweig BA, Showers MO 1990 Interactions of thyrotropin-releasing hormone, phorbol ester, and forskolin-sensitive regions of the rat thyrotropin β gene. Mol Endocrinol 4:829-836
19. Nelson EJ, Li CR, Bangalore R, Benson T, Kass RS, Hinkle RM 1994 Effects of thapsigargin and 2,5-tert-butylhydroquinone on L-type voltage gated channels. Biochem J 302:147-154
20. Akerman SN, Zorec R, Cheeck TR, Moreton RB, Berridge MJ, Mason WT 1991 Fura-2 imaging of thyrotropin-releasing hormone and dopamine effects on calcium homeostasis of bovine lactotropes. Endocrinology 129: 475-488
21. Graham FL, Simely J, Russell WC, Nairn R 1977 Characteristics of a human cell line transfored by DNA from human adenovirus type 5. J Gen Virol 36:59-74
22. Graham FL, Van der Eb AJ 1973 A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467
23. Putney Jr J, Bird GSt-J 1993 The inositol phosphate-calcium signalling system in non-excitable cells. Endocr Rev 14:610-631
24. Kaji H, Casnellie J, Hinkle PM 1988 Thyrotropin-releasing hormone action in pituitary cells: protein kinase C mediated effects on the epidermal growth factor receptor. J Biol Chem 263:13588-13593
25. 2+ spike and oscillations induced by different doses of thyrotropin-releasing hormone (TRH) in individual pituitary cells and nonexcitable cells transfected with TRH receptor cDNA. Endocrinology 135:1084-1092
26. Carr FE, Shupnik MA, Burnside J, Chin WW 1989 Thyrotropin-releasing hormone stimulates the activity of the rat thyrotropin β-subunit gene promoter transfected into pituitary cells. Mol Endocrinol 3:717-724
27. 2+ channels is by diphenylbutylpiperidine antipsychotics linked to inhibition of prolactin gene expression. J Biol Chem 265: 16373-16379
28. White BA, Bauerle LR, Bancroft FC 1981 Calcium specifically stimulates prolactin synthesis and messenger RNA sequences in GH3 cells. J Biol Chem 256:5942-5945
29. Preston GM, Billis WM, White MA 1990 Transcriptional and post transcriptional regulation of the rat prolactin gene by calcium. Mol Cell Biol 10:442-448
30. Iverson RA, Day KH, d'Emden M, Day RN, Maurer RA 1990 Clustered point mutation analysis of the rat prolactin promoter. Mol Endocrinol 4:1564-1571
31. Voss JW, Wilson L, Rosenfeld MG 1991 POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter. Genes Dev 5:1309-1320
32. Yan G, Pan WT, Bancroft C 1991 Thyrotropin-releasing hormone action on the prolactin promoter is mediated by the POU protein Pit-1. Mol Endocrinol 5:535-541
33. Li S, Crenshaw EB, III, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG 1990 Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 347:528-533
34. Pfaffle RW, DiMattia GE, Parks JS, Brown MR, Wit JM, Jansen M, Van der Nat H, Van der Brande JL, Rosenfeld MG, Ingraham HA 1992 Mutation of the POU-specific domain of pit-1 and hypopituitarism without pituitary hypoplasia. Science 257:1118-1121
35. Radovick S, Nations M, Du Y, Berg LA, Weintraub BD, Wondisford FE 1992 A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency. Science 257:1115-1117
36. Haugan BB, Wood WM, Ridgway EC 1993 A thyrotrope-specific variant of Pit-1 transactivates the thyrotropin-β promoter. J Biol Chem 268:20818-20824
37. Gordon DF, Haugen BR, Sarapura VD, Nelson AR, Wood SM, Ridgway EC 1993 Analysis of Pit-1 in regulating mouse TSHβ promoter activity in thyrotropes. Mol Cell Endocrinol 96:75-84
38. Kapliloff MS, Farkash Y, Wegner M, Rosenfeld MG 1991 Variable effects of phosphorylation of Pit-1 dictated by DNA response elements. Science 253:786-789
39. Okimura Y, Howard PW, Maurer RA 1994 Pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3′,5′-monophosphate through a mechanism that does not require inducible phosphorylation of Pit-1. Mol Endocrinol 8:1559-1565
40. Fischberg DJ, Chen X-H, Bancroft C 1994 A pit-1 phosphorylation mutant can mediate both basal and induced prolactin and growth hormone promoter activity. Mol Endocrinol 8:1566-1573
41. Lipkin SM, Naar AM, Kalla KA, Sack RA, Rosenfeld MG 1993 Identification of a novel zinc finger protein binding a conserved element critical for Pit-1 dependent growth hormone gene expression. Genes Dev 7:1674-1687
42. Cohen DR, Ferreira CP, Gentz R, Franza BR, Curran T 1989 The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev 3:173-184
43. Kim KM, McClaskey JH, Bodenner DL, Weintraub BD 1993 An AP-1-like factor and the pituitary-specific factor pit-1 are both necessary to mediate hormonal induction of human thyrotropin β gene expression. J Biol Chem 268:23366-23375
44. Gille H, Sharrocks AP, Shaw PE 1992 Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358:414-418
45. Graham R, Gilman M 1991 Distinct protein targets for signals acting at the c-fos serum response element. Science 251:189-192
46. Bading H, Ginty DD, Greenburg ME 1993 Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 260:181-186