Synaptophysin expression in the human spinal cord: Diagnostic implications of an immunohistochemical study

American Journal of Surgical Pathology

Volumn 20, Issue 3, 1996, Pages 273-276

  Zhang, Paul J ^a   Rosenblum, Marc K ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Gangliogliomas; Ganglion cell tumors; Synaptophysin

Indexed keywords

SYNAPTOPHYSIN;

ARTICLE; GLIOMA; HUMAN; HUMAN TISSUE; PERIKARYON; PROTEIN EXPRESSION; SPINAL CORD; SYNAPSE VESICLE; TUMOR DIAGNOSIS; TUMOR LOCALIZATION;

BRAIN NEOPLASMS; GANGLIOGLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; NEURONS; REFERENCE VALUES; SPINAL CORD; SYNAPTOPHYSIN; TISSUE DISTRIBUTION;

EID: 0030044177     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199603000-00002     Document Type: Article

References (24)

1. Caccamo D, Herman MM, Urich H, Rubinstein LJ. Focal neuronal gigantism and cerebral cortical thickening after therapeutic irradiation of the central nervous system. Arch Pathol Lab Med 1989;113:880-5.
2. Carpenter MB, Sutin J. Human neuroanatomy, 8th ed. Baltimore: Williams and Wilkins, 1983.
3. Coffin CM, Braun JT, Wick MR, Dehner LP. A clinicopathologic and immunohistochemical analysis of 53 cases of medulloblastoma with emphasis on synaptophysin expression. Mod Pathol 1990;3:164-9.
4. Diepholder HM, Schwechheimer K, Mohadjer M, Knoth R, Volk B. A clinicopathologic and immunomorphologic study of 13 cases of ganglioglioma. Cancer 1991;68:2192-201.
5. Goto S, Hirano A, Pearson J. Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia. Acta Neuropathol 1990;79:647-52.
6. Goto S, Hirano A, Rojas-Corona RR. A comparative immunohistochemical study of human cerebellar cortex in X-chromosome linked copper malabsorption (Menkes' kinky hair disease) and granule cell type cerebellar degeneration. Neuropathol Appl Neurobiol 1989;15:419-31.
7. Goto S, Korematsu K, Nagahiro S, Ushio Y. Distinct neuronal subset reveals perikaryal immunostaining for synaptophysin (protein p38) in the striatum of rats. Acta Neuropathol 1993;86:302-5.
8. Gould VE, Lee I, Wiedenmann B, Moll R, Chejfec G, Franke WW. Synaptophysin: a novel marker for neurons, certain neuroendocrine cells, and their neoplasms. Hum Pathol 1986;17:979-83.
9. Gould VE, Wiedenmann B, Lee I, Schwechheimer K, Dockhorn-Dworniczak B. Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry. Am J Pathol 1987;126:243-57.
10. Hoog A, Gould VE, Grimelius L, Franke WW, Falkmer S, Chejfec G. Tissue fixation methods alter the immunohistochemical demonstrability of synaptophysin. Ultrastruct Pathol 1988;12:673-8.
11. Ikemoto A, Kawanami T, Llena JF, Hirano A. Immunocytochemical studies on synaptophysin in the anterior horn of lower motor neuron disease. J Neuropathol Exp Neurol 1994;53:196-201.
12. Jahn B, Schiebler W, Ouimet C, Greengard P. A 38,000 dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci USA 1985;82:1437-41.
13. Krouwer HGJ, Davis RL, McDermott MW, Hoshino T, Prados MD. Gangliogliomas: a clinicopathological study of 25 cases and review of the literature. J Neuro-Oncol 1993;17: 139-54.
14. Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott IR, Miller DC. Central nervous system gangliogliomas. II. Clinical outcome. J Neurosurg 1993;79:867-73.
15. Miettinen M. Synaptophysin and neurofilament proteins as markers for neuroendocrine tumors. Arch Pathol Lab Med 1987;111:813-8.
16. Miller DC, Koslow M, Budzilovich G, Burstein DE. Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms. Hum Pathol 1990;21: 271-6.
17. Miller DC, Lang FF, Epstein FJ. Central nervous system gangliogliomas. I. Pathology. J Neurosurg 1993;79:859-66.
18. Navone F, Jahn R, DiGioia G, Stukenbrok H, Greengard P, de Camilli P. Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. J Cell Biol 1986;103:2511-27.
19. Rehm H, Weidenmann B, Betz H. Molecular characterization of synaptophysin: a major calcium binding protein of the synaptic vesicle membrane. EMBO J 1986;5:535-41.
20. Smith TW, Nikulasson S, De Girolami U, De Gennarro LJ. Immunohistochemistry of synapsin I and synaptophysin in human nervous system and neuroendocrine tumors: applications in diagnostic neuro-oncology. Clin Neuropathol 1993;12:335-42.
21. Thomas L, Hartung K, Langosch D, Rehm H, Bamberg E, Franke WW, Betz H. Identification of synaptophysin as a hexameric channel protein of the synaptic vesicle membrane. Science 1988;242:1050-3.
22. Trimble WS, Scheller RH. Molecular biology of synaptic vesicle-associated proteins. Trends Neurosci 1988;11:241-2.
23. Wiedenmann B, Franke WW. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mw 38,000 characteristic of presynaptic vesicles. Cell 1985;45: 1017-28.
24. Wiedenmann B, Huttner WB. Synaptophysin and chromogranins/secretogranins - widespread constituents of distinct types of neuroendocrine vesicles and new tools in tumor diagnosis. Virchows Arch B Cell Pathol 1989;58:95-121.