Characterization of metabotropic glutamate receptor-mediated facilitation of N-methyl-D-aspartate depolarization of neocortical neurones

British Journal of Pharmacology

Volumn 117, Issue 4, 1996, Pages 675-683

  Rahman, Shafiqur ^a,b   Neuman, Richard S ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Calcium; Cortical neurones; Desensitization; Metabotropic glutamate receptors; NMDA; Phospholipase C; Transmitter interaction

Indexed keywords

2 AMINO 3 PHOSPHONOPROPIONIC ACID; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 8 BROMO CYCLIC AMP; 8 BROMO CYCLIC GMP; ARACHIDONIC ACID; CALCIUM; CALCIUM CHANNEL; CARBACHOL; GLUTAMATE RECEPTOR AGONIST; KAINIC ACID; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; NIFEDIPINE; PHENYLEPHRINE; PHORBOL DIACETATE; PHOSPHOLIPASE C; PROTEIN KINASE C; QUISQUALIC ACID; RECEPTOR SUBTYPE; SEROTONIN; STAUROSPORINE; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CALCIUM TRANSPORT; CONTROLLED STUDY; DEPOLARIZATION; DESENSITIZATION; ENZYME ACTIVATION; FACILITATION; MALE; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030043077     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15243.x     Document Type: Article

References (65)

1. 2+ signal transduction. J. Biol. Chem., 267, 13361-13368.
2. AGHAJANIAN, G.K. & RASMUSSEN, K. (1989). Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneuron in adult rat brain slices. Synapse, 3, 331-338.
3. AGOPYAN, N. & AGOPYAN, I. (1991). Effects of protein kinase C activators and inhibitors on membrane properties, synaptic responses, and cholinergic actions in CA1 subfield of rat hippocampus in situ and in vitro. Synapse, 7, 193-206.
4. ANIKSZTEJN, L., BREGESTOVSKI, P. & BEN-ARI, Y. (1991). Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA responses. Eur. J. Pharmacol., 205, 327-328.
5. ANIKSZTEJN, L., OTANI, S. & BEN-ARI, Y. (1992). Quisqualate metabotropic receptors modulate NMDA currents and facilitate induction of long-term potentiation through protein kinase C. Eur. J. Neurosci., 4, 500-505.
6. ARAMORI, I. & NAKANISHI, S. (1992). Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron, 8, 757-765.
7. BAIRD, J.G., CHALLIS, R.A.J. & NAHORSKI, S.R. (1991). Role for ionotropic and metabotropic receptors in quisqualate-stimulated inositol polyphosphate accumulation in rat cerbral cortex. Mol. Pharmacol., 39, 745-753.
8. BERRIDGE, M.J. (1987). Inositol triphosphate and diacylglycerol: two interacting second messengers. Annu. Rev. Biochem., 56, 159-193.
9. BERRIDGE, M.J. (1993). Inositol triphosphate and calcium signalling. Nature, 361, 315-325.
10. BIRRELL, G.J. & MARCOUX, F.W. (1993). Excitatory amino acid receptor-stimulated phosphoinositide turnover in primary cerebrocortical cultures. Br. J. Pharmacol., 109, 379-385.
11. BIRSE, E.F., EATON, S.A., JANE, D.E., JONES, P.L.S., PORTER, R.H.P., POOK, P.C.K., SUNTER, D.C., UDVARHELYI, P.M., WHARTON, B., ROBERTS, P.J., SALT, T.E. & WATKINS, J.C. (1993). Phenylglycine derivatives as new pharmacological tools for investigating the role of matabotropic glutamate receptors in the central nervous system. Neurosci., 52, 481-488.
12. BLEAKMAN, D., RUSIN, K.I., CHARD, P.S., GLAUM, S.R. & MILLER, R.J. (1992). Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn. Mol. Pharmacol., 42, 192-196.
13. BOCKAERT, J., PIN, J. & FAGNI, J.P. (1993). Metabotropic glutamate receptors: an original family of G protein-coupled receptors. Fundam. Clin. Pharmacol., 7, 473-485.
14. BOSS, V. & CONN, P.J. (1992). Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices. J. Neurochem., 59, 2340-2343.
15. CERNE, R., RUSIN, K.I. & RANDIC, M. (1993). Enhancement of the N-methyl-D-aspartate response in spinal dorsal horn neurons by cAMP-dependent protein kinase. Neurosci. Lett., 161, 124-128.
16. CHALLISS, R.A.J., MISTRY, R., GRAY, D.W. & NAHORSKI, S.R. (1994). Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex. Br. J. Pharmacol., 112, 231-239.
17. COLLINS, C.G.S. (1993). Actions of agonists of metabotropic glutamate receptors on synaptic transmission and transmitter release in the olfactory cortex. Br. J. Pharmacol., 108, 422-430.
18. + + flux in Blowfly salivary glands. Biochem. J., 180, 655-661.
19. GADDUM, J.H. (1945). Log normal distributions. Nature, 156, 463-466.
20. HARRISON, N.L. & SIMMONDS, M.A. (1985). Quantitative studies on some antagonists of N-methyl-D-aspartate in slices of rat cerebral cortex. Br. J. Pharmacol., 84, 381-391.
21. HARVEY, J. & COLLINGRIDGE, G.L. (1993). Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices. Br. J. Pharmacol., 109, 1085-1090.
22. HARVEY, J., FRENGUELLI, B.G., SUNTER, D.C., WATKINS, J.C. & COLLINGRIDGE, G.L. (1991). The actions of 1S,3R-ACPD, a glutamate metabotropic receptor agonist in area CA1 of rat hippocampus. Br. J. Pharmacol., 104, 75P.
23. HONORE, T., DAVIES, SN., DREJER, J., FLETCHER, E.J., JACOBSEN, P., LODGE, D. & NIELSEN, F.E. (1987). Potent and competitive antagonism of non-NMDA receptors by FG 9041 and FG 9065. Soc. Neurosci. Abst., 13, 383.
24. 2+ mobilization in rat cerebellar neurons. Eur. J. Pharmacol., 186, 363-365.
25. KELSO, S.R., NELSON, T.E. & LEONARD, J.P. (1992). Protein kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes. J. Physiol., 449, 705-718.
26. KENDALL, D.A. & NAHORSKI, S.R. (1984). Inositol phospholipid hydrolysis in rat cerebral cortical slices: II. calcium requirement. J. Neurochem., 42, 1388-1394.
27. KINNEY, G.A. & SLATER, N.T. (1993). Potentiation of NMDA receptor-mediated transmission in turtle cerebellar granule cells by activation of metabotropic glutamate receptors. J. Neurophysiol., 69, 585-594.
28. LORENTE DE NO, R. (1949). In Physiology of the Nervous System, 3rd edn., ed. Fulton, J.F. Ch. XV. pp. 288-330. New York: Oxford University Press.
29. MANZONI, O.J.J., FINIELS-MARLIER, F., SASSETT, I., BOCKAERT, J., PEUCH, C. & SLADECZEK, F. (1990). The glutamate receptor of the Qp type activates protein kinase C and is regulated by protein kinase C. Neurosci. Lett., 109, 146-151.
30. MANZONI, O.J.J., POULAT, F., SAHUQUET, A., DO, E., SASSETTI, I., BOCKAERT, J. & SLADECZEK, F.A.G. (1991). Pharmacological characterization of the quisqualate receptor coupled to phospholipase C (Qp) in striatal neurons. Eur. J. Pharmacol., 207, 231-241.
31. MARKRAM, H. & SACKMAN (1994). Calcium transients in dendrites of neocortical neurons evoked by single subthreshold excitatory postsynaptic potentials via low-voltage-activated calcium channels. Proc. Natl. Acad. Sci. U.S.A., 91, 5207-5211.
32. MARKRAM, H. & SEGAL, M. (1992). The inositol 1,4,5-triphosphate pathway mediates cholinergic potentiation of rat hippocampal neuronal responses to NMDA. J. Physiol., 447, 513-533.
33. MILLER, B., SARANTIS, M., TRAYNELIS, S.F. & ATTWELL, D. (1992). Potentiation of NMDA receptor currents by arachidonic acid. Nature, 355, 722-725.
34. MINAKAMI, R., KATSUKI, F. & SUGIYAMA, H. (1993). A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon. Biochem. Biophy. Res. Commun., 194, 622-627.
35. 2+ mobilization in hippocampal neurons. Proc. Natl. Acad. Sci. U.S.A., 83, 8737-8741.
36. NAKANISHI, S. (1994). Metabotropic glutamate receptors: synaptic transmission, modulation and plasticity. Neuron, 13, 1031-1037.
37. NEDERGAARD, S., ENGBERG, I. & FLATMAN, J.A. (1987). The modulation of excitatory amino acid responses by serotonin in the cat neocortex in vitro. Cell. Mol. Neurobiol., 7, 367-379.
38. NEUMAN, R.S., BEN-ARI, Y., GHO, M. & CHERUBINI, E. (1988). Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro. Neurosci. Lett., 92, 64-68.
39. 2) receptors enhance depolarization of neocortical neurons by N-methyl-D-aspartate. Br. J. Pharmacol., 107, 11P.
40. NEUMAN, R.S. & RAHMAN, S. (1993). Mechanisms of underlying facilitation of NMDA depolarization by thapsigargin, cyclopiazonic acid and A23187 at cortical pyramidal neurons. Soc. Neurosci. Abstr., 19, 730.7.
41. NEUMAN, R.S. & RAHMAN, S. (1995). Depolarization of cortical neurons by N-methyl-D-aspartate (NMDA) is facilitated by metabotropic glutamate agonists. West. Pharmacol. Soc. Abstr., 38, T4.
42. NIESEN, C., CHARLTON, M.P. & CARLEN, P.L. (1991). postsynaptic and presynaptic effects of the calcium chelator BAPTA on synaptic transmission in rat hippocampal dentate granule neurons. Brain Res., 555, 319-325.
43. PALMER, E., MONAGHAN, D.T. & COTMAN, C.W. (1989). Trans-ACPD, a selective agonist to the PI coupled excitatory amino acid receptor. Eur. J. Pharmacol., 166, 585-587.
44. PIN & DUVOSIN, (1995). The metabotropic glutamate receptors: structure and functions. Neuropharmacol., 34, 1-26.
45. PONTZER, N.J., MADAMBA, S., SIGGINS, G.R. & CREWS, F.T. (1992). Concentrations of carbachol stimulating phosphoinositide hydrolysis cause a sustained decrease in membrane potential and firing rate: role on inositol and inositol polyphosphate second messengers. Brain Res., 597, 189-199.
46. 2A signal transduction in senescent rats: reversal following inhibition of protein kinase C. Neurosci., 66, 891-901.
47. 2 receptors facilitates depolarization of neocortical neurons by N-methyl-D-aspartate. Eur. J. Pharmacol., 231, 347-354.
48. 2 receptor desensitization. Eur. J. Pharmacol., 238, 173-180.
49. 2) receptor induced homologous and heterologous desensitization. Brain Res., 631, 349-351.
50. RAHMAN, S. & NEUMAN, R.S. (1993d). Thapsigargin, cyclopiazonic acid and A23187 facilitate NMDA receptor mediated depolarization of rat cortical neurons. Soc. Neurosci. Abstr., 23, 730.8.
51. REYNOLDS, J.N., BASKYS, A. & CARLEN, P.L. (1988). The effects of serotonin on N-methyl-D-aspartate and synaptically evoked depolarizations in rat neocortical neurons. Brain Res., 456, 286-292.
52. RHEE, S.G., KIM, H., SUH, P.G.& CHOI, W.C. (1991). Multiple forms of phosphoinositide-specific phospholipase C and different modes of activation. Biochem. Soc. Trans., 19, 337-341.
53. RUEGG, U.T. & BURGESS, G.M. (1989). Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Trends Pharmacol. Sci., 10, 218-220.
54. SAYER, R.J., SCHWINDT, P.C. & CRILL, W.E. (1992). Metabotropic glutamate receptor-mediated suppression of L-type calcium current in acutely isolated neocortical neurons. J. Neurophysiol., 68, 833-842.
55. SCHOEPP, D.D., BOEKAERT, J. & SLADECZEK, F. (1990a). Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors. Trends Pharmacol., 11, 508-515.
56. SCHOEPP, D.D. & CONN, P.J. (1993). Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol. Sci., 14, 13-20.
57. SCHOEPP, D.D., JOHNSON, B.G., SMITH, E.C.R. & MCQUAID, L.A. (1990b). Steroselectivity and mode of inhibition of phosphoinositide coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid. Mol. Pharmacol., 38, 222-228.
58. SHERMAN, W.R., GISH, B.G., HONCHAR, M.P. & MUNSELL, L.Y. (1986). Effect of lithium on phosphoinositide metabolism in vivo. Fed. Proc., 45, 2639-2646.
59. SHIGEMOTO, R., NAKANISHI, S. & MIZUNU, N. (1992). Distribution of the messenger RNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat. J. Comp. Neural., 322, 121-135.
60. SHIGEMOTO, R., NOMURA, S., OHISHI, H., SUGIHARA, H., NAKANISHI, S. & MIZUNO, N. (1993). Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci. Lett., 163, 53-57.
61. 2+ dependent protein kinase. Biochem. Biophysic. Res. Commun., 135, 397-420.
62. TANABE, Y., NOMURA, A., MASU, M., SHIGEMOTO, R., MIZUNU, N. & NAKANISHI, S. (1992). Signal transduction, pharmacological properties and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J. Neurosci., 13, 1372-1378.
63. + + ATPase. Proc. Natl. Acad. Sci. U.S.A., 87, 2466-2470.
64. THOMSON, A.M. (1990). Augmentation by glycine and blockade by 6-cyano-7-nitroquinoxaline-2,3-Dione (CNQX) of responses to excitatory amino acids in slices of rat neocortex. Neurosci., 39, 69-79.
65. WOJCIKIEWICZ, R.J.H., TOBIN, A.B. & NAHORSKI, S.R. (1993). Desensitization of cell signalling mediated by phosphoinositidase C. Trends Pharmacol. Sci., 14, 279-285.