Proto-Oncogene Products Vav and c-Cbl Are Involved in the Signal Transduction through Grb2/Ash in Hematopoietic Cells

Acta Haematologica

Volumn 95, Issue 3-4, 1996, Pages 236-242

  Hanazono, Yutaka ^a   Odai, Hideharu ^a   Sasaki, Ko ^a   Iwamatsu, Akihiro ^b   Yazaki, Yoshio ^a   Hirai, Hisamaru ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KIRIN BREWERY CO LTD   (Japan)

Author keywords

C Cbl; GM CSF; Grb2 Ash; Tyrosine phosphorylation; Vav

Indexed keywords

ERYTHROPOIETIN; GENE PRODUCT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INTERLEUKIN 3; PROTEIN TYROSINE KINASE;

CONFERENCE PAPER; CONTROLLED STUDY; FIBROBLAST; GENE ACTIVATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; CELL CYCLE PROTEINS; ERYTHROPOIETIN; GRANULOCYTE COLONY-STIMULATING FACTOR; GRB2 ADAPTOR PROTEIN; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-3; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS C-VAV; RAS PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TUMOR CELLS, CULTURED; TYROSINE; UBIQUITIN-PROTEIN LIGASES;

EID: 0030043033     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000203884     Document Type: Article

References (28)

1. Matuoka K, Shibata M, Yamakawa A, Takena-wa T: Cloning of ASH. a ubiquitous protein composed of one Src homology (SH)2 and two SH3 domains, from human and rat cDNA libraries. Proc Natl Acad Sci USA 1992;89: 9015.
2. Sucn KL, Bustelo XR, Pawson T, Barbacid M: Molecular cloning of the mouseGrb2gene: Differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Mol Cell Biol 1993; 13: 5500.
3. af through the formation of a complex of receptor. Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 1993;73: 611.
4. Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D: The SH2 and SH3 domains of mammalian Grb2 couple the F.GF receptor for the Ras activator mSosl. Nature 1993,363: 83.
5. Rozakis-Adcock M, McGlade J, Mbamalu G, Pclicci G, Daly R, Li W, Batzer A, Thomas S, Brugge J, Pelicci PG, Schlessinger J, Pawson T: Association of the She and Grb2/Scm5 SH2-containing proteins is implicated in activation of the Ras pathw ay by tyrosine kinases. Nature 1992:360:689.
6. Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ Jr., Backer JM, Ullrich A, White MF, Schlessinger J: The SH2/ SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and She: Implications for insulin control ofrassignalling. EMBO J 1993:12:1929.
7. Li W, Nishimura R, Kashishian A, Batzer AG, Kim WJH, Cooper JA, Schlessinger J: A new function for a phosphotyrosine phosphatase: Linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol 1994:14:509.
8. Chardin P, Camonis JH, Gale NW, van Aelst L, Schlcssingcr J, Wiglcr MH, Bar SD: Human Sosl: A guanine nucleotide exchange factor for Ras that binds to GRB2. Science 1993:260: 1338.
9. Gout I, Dhand R, Hiles ID, Fry MJ, Panayotou G, Das P, Truong O, Totty NF, Hsuan J, Booker GW, Campbell ID, Watcrficld MD: The GTPase dynamin binds to and is activated by a subset of SH3 domains. Cell 1993:75:25.
10. Miki H, Miura K, Matuoka K, Nakata T, Hiro-kawa N, Orita S, Kaibuchi K, Takai Y, Takena-wa T: Association of Ash/Grb-2 with dynamin through the Src homology 3 domain. J Biol Chem 1994:269:5489.
11. Tanaka S, Morishita T, Hashimoto Y, Hattori S, Nakamura S, Shibuya M, Matsuoka K, Ta-kcnawa T, Kurata T, Nagashima K, Matsuda M: C3G. a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc Natl Acad Sci USA 1994;91: 3443.
12. Cutler RL, Liu L, Damen JE, Krystal G: Multiple cytokines induce the tyrosine phosphorylation of She and its association with Grb2 in hemopoietic cells. J Biol Chem 1993,268: 21463.
13. Damcn JE, Liu L, Cutler RL, Krystal G: Erythropoietin stimulates the tyrosine phosphorylation of She and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. Blood 1993:82:2296.
14. Sato N, Sakamaki K, TcradaN, Arai K, Miyaji-ma A: Signal transduction by the high-affinity GM-CSF receptor: Two distinct cytoplasmic regions of the common p subunit responsible for different signaling. EMBO J 1993:12:4181.
15. Lioubin MN, Myles GM, Carlberg K, Bowtell D, Rahrschneider LR: She, Grb2. Sosl, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells. Mol Cell Biol 1994; 14:5682.
16. Wclham MJ, Duronio V, Leslie KB, Bowtell D, Schrader JW: Multiple hematopoietins, with the exception of interleukin-4, induce modification of She and mSosl, but not their translocation. J Biol Chcm 1994;269:21165.
17. Katzav S, Martin-Zanca D, Barbacid M:vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBOJ 1989,8:2283.
18. Komatsu N, Nakauchi H, Miwa A, Ishihara T, Eguchi M, Moroi M, Okada M, Sato Y, Wada H, Yawata Y, Suda T, Miura Y: Establishment and characterization of a human leukemic cell line with megakaryocytic features: Dependence on granulocyte-macrophage colony-stimulating factor interleukin 3, or erythropoietin for growth and survival. Cancer Res 1991;51:341.
19. Bustelo XR, Ledbetter JA, Barbacid M: Product of rav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature 1992:356:68.
20. Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessingcr J: Tyrosine phosphorylation ofvavproto-oncogene product containing SH2 domain and transcription factor motifs. Nature 1992;356:71.
21. Boguski MS, Bairoch A, Attwood A, Michaels GS: Proto-rav and gene expression. Nature 1993;358:113.
22. Gulbins E, Coggeshall KM, Baier G, Katzav S, Burn P, Altman A: Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Science 1993;260:822.
23. Gulbins E, Coggeshall KM, Langlct C, Baier G, Bonnefoy-Berard N, Burn P, Wittinghofer A, Katzav S, Altman A: Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein. Mol Cell Biol 1994; 14:906.
24. Langdon WY, Hartley JW, Klinken SP, Ru-scetti SK, Morse HC III:\-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc Natl Acad Sci USA 1989,86:1168.
25. Blake TJ, Shapiro M, Morse HC III, Langdon WY: The sequences of the human and mouse c-cblproto-oncogenes show'v-cblwas generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene 1991,6:653.
26. Ren R, Mayer BJ, Cicchetti P, Baltimore D: Identification of a ten-amino acid proline-rich SH3 binding site. Science 1993;259:1157.
27. Olivier JP, Raabe T, Henkcmeycr M, Dickson B, Mbamalu G, Margolis B, Schlessinger J, Hafen E, Pawson T: ADrosophilaSH2-SH3 adaptor protein implicated in coupling the sev-enless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 1993; 73:179.
28. Ye ZS, Baltimore D: Binding of Vav to Grb2 through dimerization of Src homology 3 domains. Proc Natl Acad Sci USA 1994;91: 12629.