메뉴 건너뛰기




Volumn 24, Issue 2, 1996, Pages 172-179

Pharmacokinetics and metabolism of EXP921, a novel cognitive enhancer, in rats

Author keywords

[No Author keywords available]

Indexed keywords

5,5 BIS(4 PYRIDINYLMETHYL) 5H CYCLOPENTA[2,1 B:3,4 B']DIPYRIDINE; 5,5 BIS(4 PYRIDINYLMETHYL) 5H CYCLOPENTA[2,1 B:3,4 B']DIPYRIDINE N' OXIDE; DRUG METABOLITE; EXP 696; EXP 921; NOOTROPIC AGENT; UNCLASSIFIED DRUG;

EID: 0030042976     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (4)

References (24)
  • 1
    • 0002928088 scopus 로고
    • Neurochemistry of Alzheimer's disease
    • G. J. Siegel, B. Agranoff, R. W. Albers, and P. Molinoff. eds., 4th ed., Raven Press. New York
    • R. Katzman and L. J. Thal: Neurochemistry of Alzheimer's disease. In "Basic Neurochemistry: Molecular Cellular, and Medical Aspects" (G. J. Siegel, B. Agranoff, R. W. Albers, and P. Molinoff. eds.), 4th ed., pp. 827-838. Raven Press. New York, 1989.
    • (1989) Basic Neurochemistry: Molecular Cellular, and Medical Aspects , pp. 827-838
    • Katzman, R.1    Thal, L.J.2
  • 2
    • 0025123674 scopus 로고
    • Cholinergicdopaminergic interactions in cognition performance
    • E. D. Levin, S. R. McGurk, J. E. Rose, and L. L. Butcher: Cholinergicdopaminergic interactions in cognition performance. Behav. Neural Biol. 54, 271-299 (1990).
    • (1990) Behav. Neural Biol. , vol.54 , pp. 271-299
    • Levin, E.D.1    McGurk, S.R.2    Rose, J.E.3    Butcher, L.L.4
  • 3
    • 0025943365 scopus 로고
    • Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine
    • C. M. Lopez, S. Govoni, F. Battaini, S. Bergamaschi, A. Longoni, C. Giaroni, and M. Trabucchi: Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Pharmacol Biochem. Behav. 39, 835-840 (1991).
    • (1991) Pharmacol Biochem. Behav. , vol.39 , pp. 835-840
    • Lopez, C.M.1    Govoni, S.2    Battaini, F.3    Bergamaschi, S.4    Longoni, A.5    Giaroni, C.6    Trabucchi, M.7
  • 6
    • 0008922631 scopus 로고
    • Efficacy and side effects of THA in Alzheimer's disease patients
    • E. Giacobini and R. Becker, eds., Taylor and Francis, New York
    • V. Kumazr: Efficacy and side effects of THA in Alzheimer's disease patients. In "Current Research in Alzheimer Therapy" (E. Giacobini and R. Becker, eds.), pp. 225-229. Taylor and Francis, New York, 1988.
    • (1988) Current Research in Alzheimer Therapy , pp. 225-229
    • Kumazr, V.1
  • 7
    • 0022899577 scopus 로고
    • Oral tetrahydroaminoacridine in long term treatment of senile dementia Alzheimer type
    • W. K. Summers, L. V. Majovski, G. M. Marsh, K. Tachiki, and A. Kling: Oral tetrahydroaminoacridine in long term treatment of senile dementia Alzheimer type. N. Engl. J. Med. 315, 1241-1245 (1986).
    • (1986) N. Engl. J. Med. , vol.315 , pp. 1241-1245
    • Summers, W.K.1    Majovski, L.V.2    Marsh, G.M.3    Tachiki, K.4    Kling, A.5
  • 10
    • 0022859808 scopus 로고
    • The determination of essential clearance, volume, and residence time parameters of recirculating metabolic systems: The reversible metabolism of methylprednisolone and methylprednisone in rabbits
    • W. F. Ebling and W. J. Jusko: The determination of essential clearance, volume, and residence time parameters of recirculating metabolic systems: the reversible metabolism of methylprednisolone and methylprednisone in rabbits. J. Pharmacokinet. Biopharm. 14, 557-599 (1986).
    • (1986) J. Pharmacokinet. Biopharm. , vol.14 , pp. 557-599
    • Ebling, W.F.1    Jusko, W.J.2
  • 11
    • 0027488972 scopus 로고
    • Pharmacokinetics and metabolic interconversion of intravenous 4-amino-5-chloro-2-[(methyl-sulfinyl)ethoxy]-N-[2-(diemylamino)ethyl]benzamide and its sulfide and sulfone metabolites in rats
    • B.-S. Kuo, J. C. Poole, K.-K. Hwang, and H. Cheng: Pharmacokinetics and metabolic interconversion of intravenous 4-amino-5-chloro-2-[(methyl-sulfinyl)ethoxy]-N-[2-(diemylamino)ethyl]benzamide and its sulfide and sulfone metabolites in rats. J. Pharm. Sci. 82, 694-698 (1993).
    • (1993) J. Pharm. Sci. , vol.82 , pp. 694-698
    • Kuo, B.-S.1    Poole, J.C.2    Hwang, K.-K.3    Cheng, H.4
  • 12
    • 9044225332 scopus 로고
    • The pharmacokinetics of EXP921 and an N-oxide metabolite in monkey
    • Abstract 201
    • Y. N. Wong, D. L. Burcham, K. A. Holm, and S.-M. Huang: The pharmacokinetics of EXP921 and an N-oxide metabolite in monkey. ISSX Proc. 2, Abstract 201 (1992).
    • (1992) ISSX Proc. , vol.2
    • Wong, Y.N.1    Burcham, D.L.2    Holm, K.A.3    Huang, S.-M.4
  • 13
    • 0014644925 scopus 로고
    • The pharmacology and biochemistry of N-oxides
    • M. H. Bickel: The pharmacology and biochemistry of N-oxides. Pharmacol Rev. 21, 325-355 (1969).
    • (1969) Pharmacol Rev. , vol.21 , pp. 325-355
    • Bickel, M.H.1
  • 14
    • 0017848901 scopus 로고
    • The kinetics of imipramine N-oxide in man
    • A. Nagy and T. Hansen: The kinetics of imipramine N-oxide in man. Acta Pharmacol. Toxicol. 42, 58-67 (1978).
    • (1978) Acta Pharmacol. Toxicol. , vol.42 , pp. 58-67
    • Nagy, A.1    Hansen, T.2
  • 15
    • 0023607597 scopus 로고
    • Disclosure of the metabolic retroversion of trimethylamine N-oxide in humans: A pharmacogenetic approach
    • M. Al-Waiz, R. Ayesh, S. C. Mitchell, J. R. Idle, and R. L. Smith: Disclosure of the metabolic retroversion of trimethylamine N-oxide in humans: a pharmacogenetic approach. Clin. Pharmacol. Ther. 42, 608-612 (1987).
    • (1987) Clin. Pharmacol. Ther. , vol.42 , pp. 608-612
    • Al-Waiz, M.1    Ayesh, R.2    Mitchell, S.C.3    Idle, J.R.4    Smith, R.L.5
  • 16
    • 9044254348 scopus 로고
    • Studies on the biological activity of nicotinic acid N-oxide. I. Fate of nicotinic acid N-oxide in rat
    • H. Tatsumi and O. Kanamitsu: Studies on the biological activity of nicotinic acid N-oxide. I. Fate of nicotinic acid N-oxide in rat. Yakugaku Zasshi 81, 1748-1753 (1961).
    • (1961) Yakugaku Zasshi , vol.81 , pp. 1748-1753
    • Tatsumi, H.1    Kanamitsu, O.2
  • 17
    • 0017754734 scopus 로고
    • Reduction of levopropoxyphene N-oxide to propoxyphene by dogs in vivo and rat liver microsomal fraction in vitro
    • R. E. McMahon and H. R. Sullivan: Reduction of levopropoxyphene N-oxide to propoxyphene by dogs in vivo and rat liver microsomal fraction in vitro. Xenobiotica 7, 377-382 (1977).
    • (1977) Xenobiotica , vol.7 , pp. 377-382
    • McMahon, R.E.1    Sullivan, H.R.2
  • 18
    • 0024216268 scopus 로고
    • The metabolism of chlorpromazine N-oxide in the rat
    • T. J. Jaworski, E. M. Hawes, G. McKay, and K. K. Midha: The metabolism of chlorpromazine N-oxide in the rat. Xenobiotica 18, 1439-1447 (1988).
    • (1988) Xenobiotica , vol.18 , pp. 1439-1447
    • Jaworski, T.J.1    Hawes, E.M.2    McKay, G.3    Midha, K.K.4
  • 19
    • 0025173803 scopus 로고
    • The metabolism of chlorpromazine N-oxide in man and dog
    • T. J. Jaworski, E. M. Hawes, G. McKay, and K. K. Midha: The metabolism of chlorpromazine N-oxide in man and dog. Xenobiotica 20, 107-115 (1990).
    • (1990) Xenobiotica , vol.20 , pp. 107-115
    • Jaworski, T.J.1    Hawes, E.M.2    McKay, G.3    Midha, K.K.4
  • 20
    • 0027956093 scopus 로고
    • Determination of linopirdine and its N-oxide metabolites in rat plasma by liquid chromatography
    • D. C. Rakestraw, D. A. Bilski, and G. L. Lam: Determination of linopirdine and its N-oxide metabolites in rat plasma by liquid chromatography. J. Pharm. Biomed. Anal. 12, 1056-1061 (1994).
    • (1994) J. Pharm. Biomed. Anal. , vol.12 , pp. 1056-1061
    • Rakestraw, D.C.1    Bilski, D.A.2    Lam, G.L.3
  • 21
    • 0027980176 scopus 로고
    • Induction of cytochrome P-450 2B and 3A in mice following the dietary administration of the novel cognitive enhancer linopirdine
    • S. Diamond, D. Rakestraw, J. O'Neil, G. Lam, and D. Christ Induction of cytochrome P-450 2B and 3A in mice following the dietary administration of the novel cognitive enhancer linopirdine. Drug Metab. Dispos. 22, 65-73 (1994).
    • (1994) Drug Metab. Dispos. , vol.22 , pp. 65-73
    • Diamond, S.1    Rakestraw, D.2    O'Neil, J.3    Lam, G.4    Christ, D.5
  • 22
    • 0002611201 scopus 로고
    • Oxidative metabolism of heterocyclic ring systems
    • W. B. Jakoby, J. R. Bend, and J. Caldwell, eds., Academic Press, New York.
    • L. A. Damani and P. A. Crooks: Oxidative metabolism of heterocyclic ring systems. In "Metabolic Basis of Detoxification" (W. B. Jakoby, J. R. Bend, and J. Caldwell, eds.), pp. 69-89. Academic Press, New York. 1982.
    • (1982) Metabolic Basis of Detoxification , pp. 69-89
    • Damani, L.A.1    Crooks, P.A.2
  • 23
    • 9044225331 scopus 로고
    • Species differentiationinlinopirdinemetabolism:formationofadespicolyl-pyridinium-N- glucuronide metabolite in humans
    • Abstract 252
    • L. E. Richards, K. F. Blom, and H. J. Pieniaszek: Species differentiationinlinopirdinemetabolism:formationofadespicolyl-pyridinium-N- glucuronide metabolite in humans. ISSX Proc. 4, Abstract 252 (1993).
    • (1993) ISSX Proc. , vol.4
    • Richards, L.E.1    Blom, K.F.2    Pieniaszek, H.J.3
  • 24
    • 9044247271 scopus 로고
    • The metabolism of DuP 996 in rats
    • Abstract 19
    • D. Rakestraw: The metabolism of DuP 996 in rats. ISSX Proc. 3, Abstract 19 (1990).
    • (1990) ISSX Proc. , vol.3
    • Rakestraw, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.