Effect of soluble P55 tumour-necrosis factor binding fusion protein on the local Shwartzman and Arthus reactions

British Journal of Pharmacology

Volumn 117, Issue 3, 1996, Pages 471-478

  Norman, Keith E ^a,c   Williams, Timothy J ^a   Feldmann, Marc ^b   Rossi, Adriano G ^a,d  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF VIRGINIA   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Haemorrhage; Lipopolysaccharide; Neutrophil accumulation; Oedema formation; Shwartzman and Arthus reactions; TNF binding fusion protein; Tumour necrosis factor

Indexed keywords

ALBUMIN; ANTIGEN; CYCLOHEXIMIDE; ERYTHROCYTE CR 51; IMMUNOGLOBULIN; INDIUM 111; IODINE 125; LIPOPOLYSACCHARIDE; PROTEIN SYNTHESIS INHIBITOR; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHUS PHENOMENON; ARTICLE; BLEEDING; CONTROLLED STUDY; DOSE RESPONSE; EDEMA; INTRADERMAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NEUTROPHIL; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RABBIT; SHWARTZMAN PHENOMENON;

EID: 0030042741     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15214.x     Document Type: Article

References (64)

1. ABE, S., GATANGA, T., YAMAKAZI, M., SOMA, G. & MIZUNO, D. (1985). Purification of rabbit tumor necrosis factor. FEBS Lett., 180, 203-206.
2. ARGENBRIGHT, L.W. & BARTON, R.W. (1991). The Shwartzman response: A novel of ICAM-1 dependent vasculitis. Agents Actions, 34, 208-210.
3. ARGENBRIGHT, L.W. & BARTON, R.W. (1992). Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo: The Shwartzman reaction revisited. J. Clin. Invest., 89, 259-272.
4. BAKER, D., BUTLER, D., SCALLON, B., O'NEILL, J.K., TURK, J.L. & FELDMANN, M. (1994). Control of established experimental encephalomyelitis by inhibiting TNF activity within the central nervous system using monoclonal antibodies and TNF receptor immunoglobulin fusion proteins. Eur. J. Immunol., 24, 2040-2048.
5. BATES, P.C., LEDGER, P.W. & ASTON, R. (1994). Recent advances in the treatment of septic shock. Exp. Opin. Ther. Patents, 4, 917-930.
6. BECK, G., HABITCHT, G.S., BENACH, J.L. & MILLER, F. (1986). Interleukin-1: a common endogenous mediator of inflammation and the local Shwartzman reaction. J. Immunol., 8, 3025-3030.
7. BEUTLER, B., MAHONEY, J., LeTRANG, N., PEKALA, P. & CERAMI, A. (1985). Purification of cachectin a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells. J. Exp. Med., 161, 984-995.
8. BROZNA, J.P. (1990). Shwartzman reaction. Sem. Thromb. Hemostas., 16, 326-332.
9. COCHRANE, G.C. & JANOFF, A. (1974). The Arthus reaction: A model of neutrophil and complement-mediated injury. In The Inflammatory Process, ed. Zweifach B.W., Grant L. & McCluskey R.T. pp. 85-162. New York: Academic Press.
10. CONROY, D.M., FRANCISCHI, J.N. & SIROIS, P. (1995). Effect of tumour necrosis factor receptor binding protein on cell infiltration induced by lipopolysacchride and sephadex beads in guinea pig lung. Inflammation, 19, 233-243.
11. COPE, A.P., ADERKA, D., DOHERTY, M., ENGELMANN, H., GIBBONS, D., JONES, A.C., BRENNAN, F.M., MAINI, R.N., WALLACH, D. & FELDMANN, M. (1992). Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic disease. Arthritis Rheum., 35, 1160-1169.
12. CYBULSKY, M.I., MCCOMB, D.J. & MOVAT, H.Z. (1988). Neutrophil leukocyte emigration induced by endotoxin. Mediator roles of interleukin 1 and tumor necrosis factor α. J. Immunol., 140, 3144-3149.
13. CYBULSKY, M.I.K., MCCOMB, D.J. & MOVAT, H.Z. (1989). Protein synthesis dependent and independent mechanisms of neutrophil emigration: different mechanisms of inflammation in rabbits induced by interleukin-1, tumor necrosis factor alpha or endotoxin versus leukocyte chemoattractants. Am. J. Pathol., 135, 227-237.
14. DENIS, M., GUOJIAN, L., WIDMER, M. & CANTIN, A. (1994). A mouse model of lung injury induced by microbial products: implication of tumor necrosis factor. Am. J. Respir. Cell Mol. Biol., 10, 658-664.
15. ENGLEMANN, H., NOVICK, D. & WALLACH, D. (1990). Two tumor necrosis factor-binding proteins from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors. J. Biol. Chem., 265, 1531-1536.
16. GATANAGE, T., HWANG, C., KHOR, W., CAPPUCCINI, F., LUCCI III, J.A., JEFFES, E.W.B., LENTZ, R., TOMICH, J., YAMAMOTO, R.S. &. GRANGER, G.A. (1990). Purification and characterisation of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients. Proc. Natl. Acad. Sci. U.S.A., 87, 8781-8784.
17. GRAU, G.E., VESIN, C., DE GROOTE, D., DELACROIX, D., GYSLER, C., PIGUET, P.F. & LAMBERT, P.H. (1991). Prevention of human TNF-induced cutaneous Shwartzman reaction and acute mortality in mice treated with anti-human TNF monoclonal antibodies. Clin. Exp. Immunol., 84, 411-414.
18. GRAY, P.W., BARRETT, K., CHANTRY, D., TURNER, M. & FELDMANN, M. (1990). Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein. Proc. Natl. Acact. Sci. U.S.A., 87, 7380-7384.
19. HASLETT, C., WORTHEN, G.S., GICLAS, P.C., MORRISSON, D.C., HENSON, J.E. & HENSON, P.M. (1987). The pulmonary vascular sequestration of neutrophils in endotoxemia is initiated by an effect of endotoxin on the neutrophil in the rabbit. Am. Rev. Respir. Dis., 136, 9-18.
20. HJORT, P.F. & RAPAPORT, S.I. (1965). The Shwartzman reaction: pathogenetic mechanisms and clinical manifestations. Annu. Rev. Med., 16, 135-168.
21. MORGAN, M.J., PALACE, G.P., EVERITT, J.E. & MALIK, A.B. (1993). TNF-a release in endotoxemia contributes to neutrophil-dependent pulmonary edema. Am. J. Physiol., 264, H1161-H1165.
22. HUMPHREY, J.H. (1955). The mechanism of Arthus reactions. I. The role of polymorphonuclear leucocytes and other factors in reversed passive Arthus reactions in rabbits. Br. J. Exp. Pathol., 36, 268-282.
23. ISSEKUTZ, A.C., LOPES, N. & ISSEKUTZ, T.B. (1992). Role of interleukin-1 and tumor necrosis factor in leucocyte recruitment to acute dermal inflammation. Mediators Inflammation, 1, 347-353.
24. KOHNO, T., BREWER, M.T., BAKER, S.L., SCHWARTZ, P.E., KING, M.W., HALE, K.K., SQUIRES, C.H., THOMPSON, R.C. & VANNICE, J.L. (1990). A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor. Proc. Natl. Acad. Sci. U.S.A., 87, 8331-8335.
25. LESSLAUER, W., TABUCHI, H., BROCKHAUS, M., SCHLAEGER, E.J., GRAU, G., PIQUET, P.F., POINTAIRE, P., VASSALLI, P. & LOETSCHER, H. (1991). Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality. Eur. J. Immunol., 21, 2883-2886.
26. MACNEE, W, & SELBY, C. (1993). Neutrophil traffic in the lungs: role of haemodynamics, cell adhesion, and deformability. Thorax, 48, 79-88.
27. MAINI, R.N. & FELDMANN, M. (1993). Is tumour necrosis factor-α (TNFα) a potential therapeutic target in rheumatoid arthritis? Concept validation studies. Sem. Clin. Immunol., 6, 5-10.
28. MOHLER, K.M., TORRANCE, D.S., SMITH, C.A., GOODWIN, R.G., STREMLER, K.E., FUNG, V.P., MADANI, H. & WIDMER, M.B. (1993). Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both carriers and TNF antagonists. J. Immunol., 151, 1548-1561.
29. MOVAT, H.Z. & BURROWES, C.E. (1984). Elicitation of the Shwartzman reaction by a combination of endotoxin and agents which activate the complement system: microvascular events. In Immunopharmacology of Endotoxicosis. ed. Agarwal, M.L. & Yoshida, M., pp. 197-212. Berlin: de Gruyter & Co.
30. MOVAT, H.Z., BURROWES, C.E., CYBULSKY, M.I. & DINARELLO, C.A. (1987). Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Am. J. Pathol., 129, 463-476.
31. 2-integrins of rat neutrophils in complement- and oxygen radical-mediated acute inflammatory injury. J. Immunol., 148, 1847-1857.
32. MULLIGAN, M.S. & WARD, P.A. (1992). Immune complex-induced lung and dermal vascular injury; differing requirements for tumor necrosis factor-α and IL-1. J. Immunol., 149, 331-339.
33. 2 integrins and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes. J. Immunol., 150, 2407-2417.
34. NOONAN, T.C., DESAI, S.N. & ARGENBRIGHT, L.W. (1993). Leukocyte adhesion molecules mediating hemorrhage from Arthus and Shwartzman responses in rabbit skin. Pharmacologist, 35, 197.
35. NORMAN, K.W., ARGENBRIGHT, L.W., WILLIAMS, T.J. & ROSSI, A.G. (1994). Role of adhesion glycoproteins CD18 and intracellular adhesion molecule-1 in complement mediated reactions of rabbit skin. Br. J. Pharmacol., 111, 117-122.
36. OLD, L.J. (1985). Tumor necrosis factor (TNF). Science, 230, 630-632.
37. OZMEN, L., PERICIN, M., HAKIMI, J., CHIZZONITE, R.A., WYSOCKA, M., TRINCHIERI, G., GATELY, M. & GAROTTA, G. (1994). Interleukin-12, interferon-γ and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction. J. Exp. Med., 180, 907-915.
38. POHLMAN, T.H., STANNESS, K.A., BEATTY, P.G., OCHS, H.D. & HARLAN, J.M. (1986). An endothelial cell surface factor(s) induced by lipopolysaccharide, interleukin-1, and tumor necrosis factor-α increases neutrophil adherence by a CDw18-dependent mechanism. J. Immunol., 136, 4548-4553.
39. 2 analogue, ZK 118.182. Eur. J. Pharmacol., 261, 237-247.
40. RAMPART, M., DE SMET, W., FIERS, W. & HERMAN, A.G. (1989). Inflammatory properties of recombinant tumor necrosis factor in rabbit skin in vivo. J. Exp. Med., 169, 2227-2232.
41. RAMPART, M. & WILLIAMS, T.J. (1988). Evidence that neutrophil accumulation induced by interleukin-1 requires both local protein biosynthesis and neutrophil CD18 antigen expression in vivo. Br. J. Pharmacol., 94, 1143-1148.
42. RIETSCHEL, E.T., KIRIKAE, T., SCHADE, F.U. MAMAT, U., SCHMIDT, G., LOPPNOW, H., ULMER, A.J., ZAHRINGER, U., SEYDEL, U., DI PADOVA, F., SCHREIER, M. & BRADE, H. (1994). Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J., 8, 217-225.
43. ROSSI, A.G. & HELLEWELL, P.G. (1994). Mechanisms of neutrophil accumulation in tissues. In Immunopharmacology of neutrophils. ed. Hellewell P.G. & Williams T.J. Chapter 10, pp. 223-243. London: Academic Press.
44. 4 in the reversed passive Arthus reaction. Br. J. Pharmacol., 107, 44-49.
45. SECKINGER, P., ZHANG, J-H., HAUPTMANN, B. & DAYER, J-M. (1990). Characterization of a tumor necrosis factor α (TNF-α) inhibitor: evidence of immunological cross-reactivity with the TNF receptor. Proc. Natl. Acad. Sci. U.S.A., 87, 5188-5192.
46. SHWARTZMAN, G. (1928). A new phenomenon of local skin reactivity to B. typhosus culture filtrate. Proc. Soc. Exp. Biol. Med., 25, 560-561.
47. STEINER, G., STUDNICKA-BENKE, A., WITZMANN, G., HOFLER, E. & SMOLEN, J. (1995). Soluble receptors for tumor necrosis factor and interleukin-2 in serum and synovial fluid of patients with rheumatoid arthritis, reactive arthritis and osteoarthritis. J. Rheumatol., 22, 406-412.
48. STETSON, C.A. & GOOD, R.A. (1951). Studies on the mechanism of the Shwartzman phenomenon. Evidence for the participation of polymorphonuclear leukocytes in the phenomenon. J. Exp. Med., 93, 49-64.
49. TARTAGLIA, L.A. & GOEDDEL, D (1992). Two TNF receptors. Immunol. Today, 13, 151-153.
50. TEIXEIRA, M.M., FAIRBAIRN, S.M., NORMAN, K.W., WILLIAMS, T.J., ROSSI, A.G. & HELLEWELL, P.G. (1994). Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of ncutrophils and endogenous mediators. Br. J. Pharmacol., 113, 1363-1371.
51. TRACEY, K.J. & CEREMI, A. (1994). Tumor necrosis factor: a pleiotropic cytokine and therapeutic target. Annu. Rev. Med., 45, 491-503.
52. ULICH, T.R., WATSON, L.R., YIN, S., GUO, K., WANG, P., THANG, H. & DEL CASTILLO, J. (1991). The intertracheal administration of endotoxin and cytokines. I. Characterization of LPS-induced IL-I and TNF mRNA expression and the LP-, IL-I-, and TNF-induced inflammatory infiltrate. Am. J. Pathol., 138, 1485-1496.
53. ULICH, T.R., YI, E.S., YIN, S., SMITH, C. & REMICK, D. (1994). Intratracheal administration of endotoxin and cytokines. VII. The soluble interleukin receptor-1 and the soluble tumor necrosis factor receptor II (p80) inhibit acute inflammation. Clin. Immunol. Immunopathol., 72, 137-140.
54. ULICH, T.R., YIN, S., REMICK, D.G., RUSSELL, D., FISENBERG, S.P. & KOHNO, T. (1993). Intratracheal administration of endotoxin and cytokines. IV The soluble tumor necrosis factor receptor type 1 inhibits acute inflammation. Am. J. Pathol., 142, 1335-1338.
55. VANDENABEELE, P., DECLERCQ, W., BEYAERT, R. & FIERS, W. (1995). Two tumour necrosis factor receptors: structure and function. Trends Cell Biol., 5, 392-399.
56. VAN ZEE, K.J., KOHNO, T., FISCHER, E., ROCK, C.S., MOLDAWER, L.L. & LOWRY, S.F. (1992). Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor a in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A., 89, 4845-4849.
57. VASSALLI, P. (1992). Thepathophysiology of tumor necrosis factors. Annu. Rev. Immunol., 10, 411-452.
58. VON UEXKULL, C., NOURSHARGH, S. & WILLIAMS, T.J. (1992). Comparative responses of human and rabbit interleukin-1 in vivo: effect of recombinant interleukin-1 receptor antagonist. Immunol., 77, 483-487.
59. WAAGE, A. (1990). Presence and involvement of TNF in septic shock. In Tumor Necrosis Factors: The Molecules and their Emerging Role in Medicine. ed. Beutler, B. pp. 275-283. New York: Raven Press.
60. WARREN, J.S., YABROFF, K.R., REMICK, D.G., KUNKEL, R.G., JOHNSON, K.J. & WARD, P.A. (1989). Tumor necrosis factor participates in the pathogenesis of acute immune complex vasculitis in the rat. J. Clin. Invest., 84, 1873-1882.
61. 111Ineosinophil accumulation in guinea-pig skin: evidence for a role for TNFα. Immunol., 84, 36-40.
62. WILLIAMS, T.J., HELLEWELL, P.G. & JOSE, P.J. (1986). Inflammatory mechanisms in the Arthus reaction. Agents Actions, 19, 66-72.
63. WINN, R.K., MILESKI, W.J., KOVACH, N.L., DOERSCHUK, C.M., RICE, C.L. & HARLAN, J.M. (1993). Role of protein synthesis and CD11/CD18 adhesion complex in neutrophil emigration in the lung. Exp. Lung Res., 19, 221-235.
64. YEH, C.G., MARSH, H.C., CARSON, G.R., BERMAN, L., CONCINO, M.F., SCESNEY, S.M., KUESTNER, R.E., SKIBBENS, R., DONAHUE, K.A. & IP, S.H. (1991). Recombinant soluble human complement receptor type 1 inhibits inflammation in the reversed passive Arthus reaction in rats. J. Immunol., 146, 250-256.