On the relation between size of necrosis and diameter of tumor spheroids

International Journal of Radiation Oncology Biology Physics

Volumn 34, Issue 2, 1996, Pages 395-401

  Groebe, Karlfried ^a   Mueller Klieser, Wolfgang ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Exogenous lactate; Human colon carcinoma spheroids; Mathematical model; Multicellular tumor spheroids; Necrosis formation; Substrate depletion

Indexed keywords

ARTICLE; CELL VIABILITY; GROWTH REGULATION; MATHEMATICAL MODEL; NECROSIS; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SPHEROID CELL; TUMOR VOLUME; TURNOVER TIME;

EID: 0030042605     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/0360-3016(95)02065-9     Document Type: Article

References (10)

1. Bourrat-Floeck, B.; Groebe, K.; Mueller-Klieser, W. Biological response of multicellular EMT6 spheroids to exogenous lactate. Int. J. Cancer 47:792-799; 1991.
2. Brach, M. Wachstumsverhalten, Sauerstoffverbrauch und Differenzierung humaner Kolon-Karzinom-Zellen in Sphäroiden bei Variation äußerer Wachstumsbedingungen. Ph.D. thesis, University of Mainz, 1989.
3. Freyer, J. P. Role of necrosis in regulating the growth saturation of multicellular spheroids. Cancer Res. 48:2432-2439; 1988.
4. Freyer, J. P.; Sutherland, R. M. Regulation of growth saturation and development of necrosis in EMT6/Ro multicell spheroids by the glucose and oxygen supply. Cancer Res. 46:3504-3512; 1986.
5. Freyer, J. P.; Sutherland, R. M. A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth. J. Cell. Physiol. 124:516-524; 1985.
6. Groebe, K.; Mueller-Klieser, W. Distribution of oxygen, nutrients, and metabolic waste concentrations in multicellular spheroids and their dependence on spheroid parameters. Eur. Biophys. J. 19:169-181; 1991.
7. Monz, B.; Karbach, U.; Groebe, K.; Mueller-Klieser, W. Proliferation and oxygenation status of WiDr spheroids in different lactate and oxygen environments. Oncol. Rep. 1:1177-1183; 1994.
8. Mueller-Klieser, W. Multicellular spheroids - A review on cellular aggregates in cancer research (Guest Editorial). J. Cancer Res. Clin. Oncol. 113:101-122; 1987.
9. Mueller-Klieser, W.; Freyer, J. P.; Sutherland, R. M. Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids. Br. J. Cancer 53:345-353; 1986.
10. Sokal, R. R.; Rohlf, F. J. Biometry. San Francisco: W. H. Freeman and Company; 1981.