Stimulation of the expression of rhoB contributes to the ability of azatyrosine to convert c-erbB-2- Transformed cells to a normal morphology

Oncology Reports

Volumn 3, Issue 1, 1996, Pages 49-55

  Monden, Yoshiaki ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Actin stress fibers; Azatyrosine; ErbB 2; Rho; Transformation

Indexed keywords

ANTIBIOTIC AGENT; AZATYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; GENE EXPRESSION; MORPHOLOGY; MOUSE; NONHUMAN; ONCOGENE C ERB; ONCOGENE RAS; PRIORITY JOURNAL;

EID: 0030042584     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.3.1.49     Document Type: Article

References (2)

1. Shindo-Okada N, Makabe O, Nakahara H and Nishimura S: Permanent conversion of mouse and human cells transformed by activated ras or raf genes to apparently normal cells by treatment with antibiotic azatyrosine. Mol Carcinogen 2: 159-167, 1989.
2. Monden Y, Nakamura T, Kojiri K, Shindo-Okada N and Nishimura S: Azatyrosine inhibits the activation of c-Raf-1, c-Jun and-AP1 but not the activation of Ras during signal transduction triggered by oncogenic c-ErbB-2. Oncol Rep 3: 33-40, 1996.