The in vitro more efficiently repaired cisplatin adduct cis-Pt.GG is in vivo a more mutagenic lesion than the relative slowly repaired cis-Pt.GCG adduct

Mutation Research - DNA Repair

Volumn 362, Issue 1, 1996, Pages 29-40

  Brandsma, J A ^a   De Ruijter, M ^a   Visse, R ^a   Van Meerten, D ^a   Van Der Kaaden, M ^a   Moggs, J G ^a,b   Van De Putte, P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

cis Diamminedichloroplatinum(II); Mutation frequency; Single adduct mutagenesis

Indexed keywords

CISPLATIN;

ARTICLE; DENATURING GRADIENT GEL ELECTROPHORESIS; ESCHERICHIA COLI; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MUTAGENESIS; MUTAGENICITY; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CISPLATIN; CYTOSINE; DNA ADDUCTS; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; DNA REPAIR; DNA, BACTERIAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; GUANINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTAGENS; NUCLEIC ACID DENATURATION; NUCLEIC ACID HETERODUPLEXES; PLASMIDS; POINT MUTATION;

ESCHERICHIA COLI;

EID: 0030042098     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/0921-8777(95)00028-3     Document Type: Article

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