Dietary fish oil (MaxEPA) enhances pancreatic carcinogenesis in azaserine-treated rats

British Journal of Cancer

Volumn 73, Issue 1, 1996, Pages 36-43

  Appel, M J ^a   Woutersen, R A ^a  

^a TNO   (Netherlands)

Author keywords

Azaserine; Cell proliferation; Fish oil; Pancreatic carcinogenesis; Prostaglandins; Rat

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; AZASERINE; FISH OIL; LINOLEIC ACID; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; THROMBOXANE B2;

ACINAR CELL; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; LIPID DIET; LOW FAT DIET; NONHUMAN; PANCREAS ADENOMA; PANCREAS CARCINOMA; PRIORITY JOURNAL; RAT;

EID: 0030041672     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.7     Document Type: Article

References (23)

1. ABOU-EL-ELA SH, PRASSE KW, FARRELL RL, CARROLL RW, WADE AE AND BUNCE OP. (1989). Effects of D,L-2-Difluoromethylornithine and indomethacin on mammary tumor promotion in rats fed high n-3 and/or n-6 fat diets. Cancer Res., 49, 1434-1440.
2. APPEL MJ AND WOUTERSEN RA. (1994). Modulation of growth and cell turnover of preneoplastic lesions and of prostaglandin levels in rat pancreas by dietary fish oil. Carcinogenesis, 15, 2107-2112.
3. APPEL MJ, VAN GARDEREN-HOETMER A AND WOUTERSEN RA. (1994). Effects of dietary linoleic acid on pancreatic carcinogenesis in rats and hamsters. Cancer Res., 54, 2113-2120.
4. BRADEN LM AND CARROLL KK. (1986). Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats. Lipids, 21, 285-288.
5. CAMPBELL HA, PITOT HC, VAN POTTER R AND LAISHES BA. (1982). Application of quantitative stereology to the evaluation of enzyme-altered foci in rat liver. Cancer Res., 42, 465-472.
6. FOLCH J, LEES M AND SLOANE-STANLEY GH. (1957). A simple method for the isolation and purification of total lipids from animal tissue. J. Biol. Chem., 226, 497-509.
7. 6-Desaturase activity in liver microsomes of rats fed diets enriched with cholesterol and/or ω-3 fatty acids. Biochem. J., 249, 351-356.
8. IP C, IP MM AND SYLVESTER P. (1986). Relevance of trans fatty acids and fish oil in animal tumorigenesis studies. In: Dietary Fat and Cancer, Ip C, Birt DF, Rogers AE and Mettlin C. (eds). Prog. Clin. Biol. Res. Series Vol. 222, pp. 283-294. Alan R. Liss: New York.
9. 2α requires specific functional groups in the molecule. J. Biol. Chem., 258, 8774-8780.
10. JURKOWSKI JJ AND CAVE WT. (1985). Dietary effects of menhaden oil on the growth and membrane lipid composition of rat mammary tumours. J. Natl Cancer Inst., 74, 1145-1150.
11. KHOO DE, FLAKS B, OZTAS H, WILLIAMSON RCN AND HABIB NA. (1991). Effects of dietary fatty acids on the early stages of neoplastic induction in the rat pancreas. Changes in fatty acid composition and development of atypical acinar cell nodules. Int. J. Exp. Pathol., 72, 571-580.
12. LONGNECKER DS (1983). Early morphologic markers for carinogenicity in rat pancreas. In Application of Biological Markers to Carcinogen Testing, Milman HA and Sell S. (eds) pp. 43-60. Plenum Press: New York.
13. MATHIAS MM AND DUPONT J. (1989). Effects of dietary fat on eicosanoid production in normal tissues. In: Carcinogenesis and Dietary Fat. Abraham S. (ed.) pp. 29-51. Kluwer Academic Publishers: Boston.
14. MINOURA T, TAKATA T, SAKAGUCHI M, TAKADA H, YAMAMURA M, HIOKI K AND YAMAMOTO M. (1988). Effect of dietary eicosapentaenoic acid on azoxymethane-induced colon carcinogenesis in rats. Cancer Res., 48, 4790-4794.
15. NATIONAL RESEARCH COUNCIL SUBCOMMITTEE ON LABORATORY ANIMAL NUTRITION. (1978). Nutrient Requirements of Domestic Animals. 10, 8-10.
16. O'CONNOR TP, ROEBUCK BD, PETERSON FJ AND CAMPBELL TC. (1985). Effect of dietary intake of fish oil and fish protein on the development of L-azaserine-induced preneoplastic lesions in the rat pancreas. J. Natl Cancer Inst., 75, 959-962.
17. O'CONNOR TP, ROEBUCK BD, PETERSON FJ, LOKESH B, KINSELLA JE AND CAMPBELL TC. (1989). Effect of dietary omega-3 and omega-6 fatty acids on development of azaserine-induced preneoplastic lesions in rat pancreas. J. Natl. Cancer Inst., 81, 858-863.
18. PLESCIA OJ AND RACIS S. (1988). Prostaglandins as physiological immunoregulators. Prog. Allergy, 44, 153-171.
19. RAO MS, UPTON MP, SUBBARO V AND SCARPELLI DG. (1982). Two populations of cells with differing proliferative capacities in atypical acinar cell foci induced by 4-hydroxyaminoquinoline-1-oxide in rat pancreas. Lab. Invest., 46, 527-534.
20. REDDY BS AND MARUYAMA H. (1986). Effect of dietary fish oil on azoxymethane-induced colon carcinogenesis in male F344 rats. Cancer Res., 46, 3367-3370.
21. REDDY BS AND SUGIE S. (1988). Effect of different levels of omega-3 and omega-6 fatty acids on azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Res., 48, 6642-6647.
22. ROEBUCK BD, LONGNECKER DS, BAUMGARTNER KJ AND THRON DC. (1985). Carcinogen-induced lesions in the rat pancreas: effects of varying levels of essential fatty acid. Cancer Res., 45, 5252-5256.
23. WOUTERSEN RA, VAN GARDEREN-HOETMER A, BAX J, FERINGA AW AND SCHERER E. (1986). Modulation of putative preneoplastic foci in exocrine pancreas of rats and hamsters. I. Interaction of dietary fat and ethanol. Carcinogenesis, 7, 1587-1593.