Inhibitors of acyl-CoA: Cholesterol acyltransferase. II. Preparation and hypocholesterolemic activity of optically active dibenz[b,e]oxepin-11-carboxanilides

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 1, 1996, Pages 222-225

  Kumazawa, Toshiaki ^a   Yanase, Masashi ^a   Shirakura, Shiro ^a   Ohishi, Eiko ^a   Yamada, Koji ^a   Matsumiya, Shigeki ^a   Kono, Motomichi ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Acyl CoA; Antiatherosclerotic amide; Cholesterol acyltransferase; Dibenz b,e oxepin 11 carboxanilide; Hypocholesterolemic amide; Molecular modeling study; Optical resolution

Indexed keywords

2 BROMO N (2,6 DIISOPROPYLPHENYL) 6,11 DIHYDRODIBENZ[B,E]OXEPIN 11 CARBOXAMIDE; ANTILIPEMIC AGENT; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; DIBENZOXEPIN DERIVATIVE; KW 3033; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HYPERCHOLESTEROLEMIA; LIVER MICROSOME; MALE; MOLECULAR MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CRICETINAE; DIBENZOXEPINS; ENZYME INHIBITORS; MESOCRICETUS; RABBITS; STEREOISOMERISM; STEROL O-ACYLTRANSFERASE;

EID: 0030041295     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.222     Document Type: Article

References (11)

1. a) Spector A. A., Mathur S. N., Kaduce T. L., Prog. Lipid Res., 18, 31 (1979);
2. b) Suckling K., E., Stange E. F., J. Lipid Res. 26, 647 (1985).
3. Sliskovic D. R., White A. D., Trends Pharmacol. Sci., 12, 194 (1991).
4. Matsuda K., Med. Res. Rev., 14, 271 (1994).
5. Kumazawa T., Yanase M., Harakawa H., Obase H., Shirakura S., Ohishi E., Oda S., Kubo K., Yamada K., J Med. Chem., 37, 804 (1994).
6. Natori K., Okazaki Y., Nakajima T., Hirohashi T., Aono S., Jpn. J. Pharmacol., 42, 517 (1986).
7. Sekiya T., Inoue S., Shirasaka T., Miyajima C., Okushima H., Suzuki K., Kawai M., Mitsuka M., Umezu K., Chem. Pharm. Bull., 42, 586 (1994).
8. O'Brien P. M., Sliskovic D. R., Blankley C J., Roth B. D., Wilson M. W., Hamelehle K. L., Krause B. R , Stanfield R. L., J Med. Chem., 37, 1810 (1994).
9. 2 for HPLC analysis.
10. MOPAC Ver. 6.00 (QCPE No. 445), Stewart J. J. P., QCPE Bull., 10, 86 (1990).
11. Matsumiya S., Kono M., Kumazawa T., Yanase M., in preparation.