Effects of fluvoxamine and dothiepin on psychomotor abilities in healthy volunteers

Pharmacology Biochemistry and Behavior

Volumn 53, Issue 2, 1996, Pages 265-269

  Fairweather, D B ^a   Ashford, J ^b   Hindmarch, I ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b Duphar House   (United Kingdom)

Author keywords

daytime activity; dothiepin; fluvoxamine; psychomotor performance

Indexed keywords

DOSULEPIN; FLUVOXAMINE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL FLICKER FUSION; CROSSOVER PROCEDURE; DAILY LIFE ACTIVITY; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY; MOOD; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PSYCHOMOTOR DISORDER; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; REACTION TIME; SEDATION; VOLUNTEER;

EID: 0030041029     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)00210-3     Document Type: Article

References (21)

1. Fairweather, D. B.; Hindmarch, I. False economies: The true cost of "cheap" drugs. Risk Controversies 4. London: The Social Affairs Unit; 1995.
2. Fairweather, D. B.; Kerr, J. S.; Harrison, D. A.; Moon, C. A. Hindmarch, I. A double blind comparison of fluoxetine and amitriptyline on cognitive function in elderly depressed patients. Hum. Psychopharmacol. 8:41-47; 1993.
3. Hale, A. S. Pinninti, N. R. Critical flicker fusion threshold and anticholinergic effects of chronic antidepressant treatment in remitted depressives. J. Psychopharmacol. 9:216-224; 1995.
4. Hanks, G. W. The effects of amitriptyline and nomifensine on critical flicker fusion threshold in an elderly population. In: Rees, L. W.; Priest, R. G., eds. Nomifensine: A pharmacological and clinical profile. Oxford: OUP; 1984:71-76.
5. Hindmarch, I. Psychomotor function and psychoactive drugs. Br. J. Clin. Pharmacol. 10:189-209; 1980.
6. Hindmarch, I. Critical flicker fusion frequency (CFF). The effects of psychotropic compounds. Pharmacopsychiatry 15(Suppl 1):44-48; 1982.
7. Hindmarch, I. Three antidepressants (amitriptyline, dothiepin, fluoxetine) with and without alcohol, compared with placebo on tests of psychomotor ability related to car driving. Hum. Psychopharmacol. 2:177-183; 1987.
8. Hindmarch, I. A pharmacological profile of fluoxetine and other antidepressants on aspects of skilled performance and car handling ability. Br. J. Psychiatry 153; 99-104; 1988.
9. Hindmarch, I.; Barwell, F.; Alford, C. A. Behavioural toxicity of antidepressants. In: Leonard, B.; Spencer, P., eds. Antidepressants: Thirty years on. London: CNS Publishers; 1990:403-409.
10. Hindmarch, I.; Bhatti, J. Z. Psychopharmacological effects of sertraline in normal, healthy volunteers. Eur. J. Clin. Pharmacol. 35:221-223; 1988.
11. Hindmarch, I.; Gudgeon, A. C. The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability. Br. J. Clin. Pharmacol. 10:145-150; 1980.
12. Hindmarch, I.; Kerr, J. S.; Sherwood, N. The effects of alcohol and other drugs on psychomotor performance and cognitive function. Alcohol Alcohol. 26:71-79; 1990.
13. Hindmarch, I.; Parrott, A. C. Repeated dose comparisons of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance. Br. J. Clin. Pharmacol. 4:167s-173s; 1977.
14. Hindmarch, I.; Subhan, Z.; and Stoker, M. J. The effects of zimeldine and amitriptyline on car driving and psychomotor performance. Acta Psychiatr. Scand. 68:141-146; 1983.
15. Johns, M. W. A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep 14:540-545; 1991.
16. Johns, M. W. Reliability and factor analysis of the Epworth sleepiness scale. Sleep 15:376-381; 1992.
17. Kerr, J. S.; Fairweather, D. B.; Mahendran, R. Hindmarch, I. The effects of paroxetine, alone and in combination with alcohol on psychomotor performance and cognitive function in the elderly. Int. Clin. Psychopharmacol. 7:101-108; 1992.
18. Ogura, C.; Kishimoto, A.; Mizukawa, R.; Matsubayashi, M.; Omura, F.; Kunimoto, N. Comparative study of the effects of 9 antidepressants on several physiological parameters in healthy volunteers. Neuropsychobiology 17:139-144; 1987.
19. Sternberg, S. Memory scanning: New findings and controversies. Q. J. Exper. Psychol. 27:1-32; 1975.
20. Wagner, W.; Plekkenpol, B.; Gray, T. E.; Vlaskamp, H.; Essers, H. Review of fluvoxamine safety database. Drugs 43 (Suppl 2): 48-54; 1992.
21. Wilde, M. I.; Plosker, G. L.; Benfield, P. Fluvoxamine: An updated review of its pharmacology and therapeutic use in depressive illness. Drugs 46:895-924; 1993.