Novel adapter proteins that link the human GM-CSF receptor to the phosphatidylino-sitol 3-kinase and Shc/Grb2/ras signaling pathways

Current Topics in Microbiology and Immunology

Volumn 211, Issue , 1996, Pages 66-75

  Jucker M ^a   Feldman, R A ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOTYROSINE; PROTEIN P 140; PROTEIN P80; UNCLASSIFIED DRUG;

CELL LINE; CONFERENCE PAPER; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LEUKEMIA; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GRB2 ADAPTOR PROTEIN; HUMANS; LEUKEMIA, MYELOID; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEINS; RAS PROTEINS; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0030040741     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-85232-9_7     Document Type: Article

References (32)

1. Areces LB, Jücker M, San Miguel J, Mui A, Miyajima A Feldman RA (1993) Ligand-dependent transformation by the receptor for human granulocyte/macrophage colony-stimulating factor and tyrosine phosphorylation of the receptor β subunit. Proc Natl Acad Sci USA 90: 3963-3967
2. Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC (1989) PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositosides in intact cells. Cell 57:167-175
3. Blaikie P, Immanuel D, Wu J, Li V, Margolis B (1994) A region of SHC distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J Biol Chem 269:32031-32034
4. Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (1990) Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem 265:19704-19711
5. Corey S, Eguinoa A, Puyana-Theall K, Bolen JB, Cantley L, Molinedo F, Jackson TR, Hawkins PT, Stephens LR (1993) Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J 12:2681-2690
6. Egan SE, Giddlings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA (1993) Association of Sos ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363:45-51
7. Fantl WJ, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F, Williams, LT. (1992) Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell 69:413-423
8. Gustafson TA, He W, Craparo A, Schaub CD, O'Neil TJ (1995) Phosphotyrosine-dependent interaction of SHC and Insulin Receptor Substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol Cell Biol 15:2500-2508
9. Hayashida K, Kitamura T, Gorman DM, Arai KI, Yokota T, Miyajima A (1990) Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci USA 87:9655-9659
10. Hu P, Margolis B, Skolnik EY, Lammers R, Ullrich A, Schlessinger J (1992) Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol Cell Biol 12:981-990
11. Jücker M, Feldman RA, Submitted
12. Kavanough WM, Williams LT (1994) An alternative to SH2 domains for binding to tyrosine phosphorylated receptors. Science 266:1862-1865
13. Kavanough WM, Klippel A, Escobedo JA, Williams LT (1992) Modification of the 85 kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells. Mol Cell Biol 12:3415-3424
14. Keegan AD, Nelms K, White M, Wang L-M, Pierce JH, Paul, W (1994) An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mcdiated IRS-1 phosphorylation and cell growth. Cell 76:811-820
15. Kitamura T, Tange T, Terasawa T, Chiba S, Kuwaki T, Miyagawa K, Piao Y-F, Miyazono K, Urabe A, Takaku F (1989) Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol 140:323-334
16. Kitamura T, Sato N, Arai K-I, Miyajima A (1991) Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for human IL-3 and GM-CSF receptors. Cell 66:1165-1174
17. Klippel A, Escobedo JA, Hu Q, Williams L (1993) A region of the 85-kilodalton (kDa) subunit of phosphatidylinosilol 3-kinase binds the 110-kDa catalytic subunit in vivo. Mol Cell Biol 13:5560-5566
18. Lanfrancone L, Pelicci G, Brizzi MF, Arouica MG, Casciari C, Giuli S, Pegoraro L, Pawson T, Pelicci PG (1995) Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the receptor β subunit. Oncogene 10:907-917
19. Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J (1992) The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70:431-442
20. McGlade J, Cheng A, Pelicci G, Pelicci P-G, Pawson T (1992) Shc proteins are phosphorylated and regulated by the v-src and v-fps protein-tyrosine kinases. Proc Natl Acad Sci (USA) 89:8869-8873
21. McGlade CJ, Ellis C, Reedijk M, Anderson D, Mbamalu , Reith AD, Panayotou G, End P, Bernstein A, Kazlauskas A, Waterfield MD, Pawson T (1992) SH2 domains of the p85α subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Mol Cell Biol 12:991-997
22. Metcalf D (1989) The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature 339:27-30
23. Miyajima A, Kitamura T, Harada N, Yokota, T, Arai K-I (1992) Cytokine receptors and signal transduction. Annu Rev Immunol 10:295-331.
24. Pleiman CM, Hertz W M, Cambier JC (1994) Activation of phosphatidylinositol-3′ kinase by src-family SH3 binding to the p85 subunit. Science 263:1609-1612
25. Pellici G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70: 93-104
26. Quelle FW, Shimoda K, Thierfelder W, Fischer, C, Kim A, Ruben SM, Cleveland JM, Pierce JH, Keegan AD, Nelms K, Paul WE, Ihle JN (1995) Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and EL-3 but are not required for autogenesis. Mol Cell Biol 15:3336-3343
27. Rozakis-Adcock M, McGlade J, Mbamalu G, Pelicci G, Daly R., Li W, Batzer A, Thomas S, Brugge J, Pelicci P G, Schlessinger J, Pawson T (1992) Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the ras pathway by tyrosine kinases. Nature 360:689-692
28. Sachs L (1990) The control of growth and differentiation in normal and leukemic blood cells. Cancer 65:2196-206
29. Silvennoinen O, Witthuhn B, Quelle FW, Cleveland JL, Yi T, Ihle JN (1993) Structure of the JAK-2 protein tyrosine kinase and its role in IL-3 signal transduction. Proc Natl Acad Sci USA 90:8429-8433
30. Skolnik EY, Lee C-H, Batzer A, Vincentini LM, Zhou M, Daly R, Myers Jr MJ, Backer JM, Ullrich A, White MF, Schlessinger J (1993) The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J 12:1929-1936
31. Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldslein BJ, White M (1991) Structure of the Insulin Receptor Substrate IRS-1 defines a unique signal transduction protein. Nature 352:73-77
32. Torigoe T, O'Connor R, Santoli D, Reed JC (1992) Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines. Blood 80:617-624