Distinct positive and negative regulatory elements control neuronal and hepatic transcription of the human transferrin gene

Journal of Neuroscience Research

Volumn 43, Issue 3, 1996, Pages 261-272

  Sawaya, B E ^a,c   Aunis, D ^b   Schaeffer, E ^a,c  

^a INSTITUT PASTEUR   (France)

^b CENTRE DE NEUROCHIMIE   (France)

^c INSERM   (France)

Author keywords

gene expression; neuronal cells; transcription; transferrin

Indexed keywords

BINDING PROTEIN; DEOXYRIBONUCLEASE I; NUCLEAR FACTOR I; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; TRANSFERRIN;

ANIMAL CELL; ARTICLE; CELL SPECIFICITY; CELL TYPE; DNA FLANKING REGION; DNA METHYLATION; ENHANCER REGION; GENE EXPRESSION REGULATION; IRON TRANSPORT; NERVE CELL; NERVE CELL CULTURE; NERVOUS SYSTEM DEVELOPMENT; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SILENCER GENE; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL LINE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CHOROID PLEXUS; DEOXYRIBONUCLEASE I; DNA FOOTPRINTING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER; METHYLATION; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; NEURONS; NUCLEAR PROTEINS; OLIGODENDROGLIA; OLIGODEOXYRIBONUCLEOTIDES; ORGAN SPECIFICITY; RECOMBINANT PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFERRIN; TUMOR CELLS, CULTURED;

EID: 0030040549     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960201)43:3<261::AID-JNR1>3.0.CO;2-H     Document Type: Article

References (38)

1. Adrian GS, Korinek, BW, Bowman BH, Yang F (1986): The human transferrin gene: 5′ region contains conserved sequences which match the control elements regulated by heavy metals, glucocorticoids and acute phase reaction. Gene 49:167-175.
2. Adrian GS, Bowman BH, Herbert DC, Weaker FJ, Adrian EK, Robinson LAK, Walker LA, Eddy CA, Riehl R, Pauerstein CJ, Yang F (1990): Human transferrin. Expression and iron modulation of chimeric genes in transgenic mice. J Biol Chem 265:13344-13350.
3. Aldred AR, Dickson PW, Marley PD, Schreiber G (1987): Distribution of transform synthesis in brain and other tissues in the rat. J Biol Chem 262:5293-5297.
4. Amemiya K, Traub R, Durham L, Major EO (1992): Adjacent nuclear factor-1 and activator protein binding sites in the enhancer of the neurotropic JC virus. A common characteristic of many brain-specific genes. J Biol Chem 267:14204-14211.
5. Augé-Gouillou C, Petropoulos I, Zakin MM (1993): Liver-enriched HNF-3α and ubiquitous factors interact with the human transferrin enhancer. FEBS Lett 323:4-10.
6. Bloch B, Popovici T, Levin MJ, Tuil D, Kahn A (1985): Transferrin gene expression visualized in oligodendrocytes of the rat brain by using in situ hybridization and immunocytochemistry. Proc Natl Acad Sci U S A 82:6706-6710.
7. Boissier F, Augé-Gouillou C, Schaeffer E. Zakin MM (1991): The enhancer of the human transferrin gene is organized in two structural and functional domains. J Biol Chem 266:9822-9828.
8. Brunel F, Ochoa A, Schaeffer E, Boissier F, Guillou Y, Cereghini S, Cohen GN, Zakin MM (1988): Interactions of DNA-binding proteins with the 5′ region of the human transferrin gene. J Biol Chem 263:10180-10185.
9. Chu HM, Fischer WH, Osborne TF, Comb MJ (1991): NF-I proteins from brain interact with the proenkephalin cAMP inducible enhancer. Nucleic Acids Res 19:2721-2728.
10. Connor JR, Fine RE (1987): Development of transferrin-positive oligodendrocytes in the rat central nervous system. J Neurosci Res 17:51-59.
11. Connor JR, Menzies SL, St Martin SM, Mufson EJ (1990): Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains. J Neurosci Res 27:595-611.
12. Durand B, Sauders M, Leroy P, Leid M, Chambon P (1992): All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DRI and DRII repeated motifs. Cell 71:73-85.
13. Espinosa de los Monteros A, Chiappelli F, Fisher RS, de Vellis J (1988): Transferrin: an early marker of oligodendrocytes in culture. Int J Dev Neurosci 6:167-175.
14. Espinosa de los Monteros A, Pena LA, de Vellis J (1989): Does transferrin have a special role in the nervous system? J Neurosci Res 24:125-136.
15. Espinosa de los Monteros A, Kumar S, Scully S, Cole R, de Vellis J (1990): Transferrin gene expression and secretion by rat brain cells in vitro. J Neurosci Res 25:576-580.
16. Espinosa de los Monteros A, Sawaya BE, Guillou F, Zakin MM, de Vellis J, Schaeffer E (1994): Brain-specific expression of the human transferrin gene. Similar elements govern transcription in oligodendrocytes and in a neuronal cell line. J Biol Chem 269:24504-24510.
17. Evans RM (1988): The steroid and thyroid hormone receptor superfamily. Science 240:889-895.
18. Graham FL, Van der Eb AJ (1973): A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
19. Guillou F, Zakin MM, Part D, Boissier F, Schaeffer E (1991): Sertoli cell-specific expression of the human transferrin gene. Comparison with the liver-specific expression. J Biol Chem 266: 9876-9884.
20. Hoyle GW, Mercer EH, Palmiter RD, Brinster RL (1994): Cell-specific expression from the dopamine β-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements. J Neurosci Res 14:2455-2463.
21. Idzerda RL, Behringer RR, Theisen M, Huggenvik J, McKnight GS, Brinster RL (1989): Expression from the transferrin gene promoter in transgenic mice. Mol Cell Biol 9:5154-5162.
22. Inoue T, Tamura T, Furuichi T, Mikoshiba K (1990): Isolation of complementary DNAs encoding a cerebellum-enriched nuclear factor I family that activates transcription from the mouse myelin basic protein promoter. J Biol Chem 265:19065-19070.
23. Lai E, Prezioso VR, Smith E, Litvin O, Costa RH, Darnell JE Jr (1990): HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes Dev 4:1427-1436.
24. Levin MJ, Tuil D, Uzan G, Dreyfus J-C, Kahn A (1984): Expression of the transferrin gene during development of non-hepatic tissues: high level of transferrin mRNA in fetal muscle and adult brain Biochem Biophys Res Commun 122:212-217.
25. Mader S, Chen JY, Cheng Z, White J, Chambon P, Gronemeyer H (1993): The patterns of binding of RAR, RXR and TR homo and heterodimers to direct repeats are dictated by the binding specificities of the DNA binding domains. EMBO J 12:5029-5041.
26. Maue RA, Kraner SD, Goodman RH, Mandel G (1990): Neuron-specific expression of the rat brain II sodium channel gene is directed by upstream regulatory elements. Neuron 4:223-231.
27. Nakabayashi H, Hashimoto T, Miyao Y, Tjong K-K, Chan J, Tamaoki T (1991): A position-dependent silencer plays a major role in repressing α-fetoprotein expression in human hepatoma. Mol Cell Biol 1:5885-5893.
28. Oh TH, Markelonis GJ, Royal CM, Bregman BS (1986): Imunocytochemical distribution of transferrin and its receptor in the developing chicken nervous system. Dev Brain Res 30:207-220.
29. Rupp RAW, Kruse U, Multhaup G, Göbel U, Beureuther K, Sippel AE (1990): Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, N'FI-B and NFI-C with homologues in the mammalian genomes. Nucleic Acids Res 18:2607-2616.
30. Sawaya B, Schaeffer E (1995): Transcription of the human transferrin gene in neuronal cells. Nucleic Acids Res 23:2206-2211.
31. Schaeffer E, Boissier F, Py M-C, Cohen GN, Zakin MM (1989): Cell type-specific expression of the human transferrin gene. Role of promoter, negative, and enhancer elements. J Biol Chem 264: 7153-7160.
32. Schaeffer E, Guillou F, Part D, Zakin MM (1993): A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells. J Biol Chem 268:23399-23408.
33. Schubert D, Heinemann S, Carlisle W, Tarikas H, Kimes B, Patrick J, Steinbach JH, Culp W, Brandt BL (1974): Clonal cell lines from the rat central nervous system. Nature 249:224-227.
34. Sladek FM, Zhong W, Lai E, Darnell JE Jr (1990): Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev 4:2353-2365.
35. Theisen M, Behringer RR, Cadd GG, Brinster RL, McKnight GS (1993): A C/EBP-binding site in the transferrin promoter is essential for expression in the liver but not the brain of transgenic mice. Mol Cell Biol 13:7666-7676.
36. Tsutsumi M, Skinner MK, Sanders-Busch E (1989): Transferrin gene expression and synthesis by cultured choroid plexus epithelial cells. J Biol Chem 264:9626-9631.
37. Wang L-H, Tsai SY, Cook RG, Beanie WG, Tsai M-J, O'Malley BW (1989): COUP transcription factor is a member of the steroid receptor superfamily. Nature 340:163-166.
38. Wilson TE, Mouw AR, Weaver CA, Millbrandt J, Parker KL (1991): The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol Cell Biol 13: 861-868.