Specific sequences of fibronectin activate the protein kinase C signal transduction pathway in invasive bladder cancer

Cancer Letters

Volumn 100, Issue 1-2, 1996, Pages 163-168

  Margolis, Eric J ^a   Choi, Jimmy C S ^a   Shu, Wei Ping ^a   Liu, Brian C S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Bladder cancer; Fibronectin; Invasion; Protein kinase C

Indexed keywords

FIBRONECTIN; PROTEIN KINASE C;

AMINO ACID SEQUENCE; ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CANCER CELL CULTURE; CANCER INVASION; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 0030040546     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(95)04096-X     Document Type: Article

References (13)

1. Liotta, L.A. (1986) Tumor cell invasion and metastases: role of extracellular matrix. Rhoads Memorial Lecture. Cancer Res., 46, 1.
2. Humphries, M.J., Obara, M., Olden, K. and Yamada, K.M. (1989) Role of fibronectin in adhesion, migration, and metastasis. Cancer Invest., 7, 373.
3. Weiss, R.E., Liu, B.C.S., Ahlering, T., Dubeau, L. and Droller, M.J. (1990) Mechanisms of human bladder tumor invasion: role of protease cathepsin B. J. Urol., 144, 798.
4. Redwood, S.M., Liu, B.C.S., Weiss, R.E., Hodge, D.E. and Droller, M.J. (1992) Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s). Cancer, 69, 1212.
5. Lester, B.R., Weinstein, L.S., McCarthy, J.B. et al. (1991) The role of G-protein in matrix-mediated motility of highly and poorly invasive melanoma cells. Int. J. Cancer, 48, 113.
6. Stracke, M.L., Guirguis, R., Liotta, L.A. et al. (1990) Pertussis toxin inhibits stimulated motility independent of the adenylate cyclase pathway in human melanoma cells. Biochem. Biophys. Res. Commun., 166, 757.
7. Gordon, J.N., Shu, W.P., Schlussel R.N., Droller, M.J. and Liu, B.C.S. (1993) Altered extracellular matrices influence cellular processes and nuclear matrix organizations of overlying human bladder urothelial cells. Cancer Res., 53, 4971.
8. Chang, Z.-L., Beezhold, D.H., Personius, C.D. and Shen, Z.-L. (1993) Fibronectin cell-binding domain triggered transmembrane signal transduction in human monocytes. J. Leukoc. Biol., 53, 79.
9. Schwartz, G.K., Redwood, S.M., Ohnuma, T., Holland. J.F., Droller, M.J. and Liu, B.C.S. (1990) Inhibition of invasion of invasive human bladder carcinoma cells by protein kinase C inhibitor staurosporine. J. Natl. Cancer Inst., 82, 1753.
10. Gopalakrishna, R. and Barsky, S.H. (1988) Tumor promoter-induced membrane-bound kinase C regulates hematogenous metastasis. Proc. Natl. Acad. Sci. USA, 85, 612.
11. Takenaga, K. and Takahashi, K. (1986) Effects of 12-O-tetradecanylphorbol-13-acetate on adhesiveness and lung-colonizing ability of Lewis lung carcinoma cells. Cancer Res., 40, 375.
12. 2+ mobilization and protein kinase C activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma cells. Cancer Res., 49, 2597.
13. Blood, C.H. and Zetter, B.R. (1989) Membrane-bound protein kinase C modulates receptor affinity and chemotactic responsiveness of Lewis lung carcinoma sublines to an elastin-derived peptide. J. Biol. Chem., 264, 10614.