The disposition and effects of two doses of dichloroacetate in adults with severe falciparum malaria

British Journal of Clinical Pharmacology

Volumn 41, Issue 1, 1996, Pages 29-34

  Krishna, Sanjeev ^a,b,c   Supanaranond, Wichai ^a   Pukrittayakamee, Sasithon ^a   Ter Kuile, Feiko ^a,d   Ruprah, Manjit ^b,e   White, Nicholas J ^a,b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e Poisons Unit   (United Kingdom)

Author keywords

Adjunctive therapy; Dichloroacetate infusion; lactic acidosis malaria; severe Plasmodiumfalciparum malaria

Indexed keywords

DICHLOROACETIC ACID; LACTIC ACID; PLACEBO; QUININE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LACTIC ACIDOSIS; MALARIA; PHARMACODYNAMICS; PHARMACOKINETICS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

EID: 0030040420     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1996.tb00155.x     Document Type: Article

References (19)

1. Krishna S, Waller D, ter Kuile F, et al. Lactic acidosis and hypoglycaemia in children with severe malaria: pathophysiological and prognostic significance. Trans R Soc Med Hyg 1994; 88: 67-73.
2. Krishna S, Supanaranond W, Pukrittayakamee S, et al. Dichloroacetate for lactic acidosis in severe malaria: a pharmacokinetic and pharmacodynamic assessment. Metabolism 1994; 43: 974-981.
3. Taylor TE, Borgstein A, Molyneux ME. Acid-base status in paediatric Plasmodium falciparum malaria. Q J Med 1993; 86: 99-109.
4. White NJ, Miller KD, Marsh K, et al. Hypoglycaemia in African children with severe malaria. Lancet 1987; i: 708-711.
5. White NJ, Ho M. The pathophysiology of malaria. Adv Parasitol 1992; 31: 84-173.
6. Waller D, Krishna S, Crawley J, et al. The course and outcome of severe malaria in Gambian children. Clin Infect Dis 1995; (in press).
7. Stacpoole PW. Lactic acidosis. Endocrinol Metab Clin North Am 1993; 22: 221-245.
8. Holloway PAH, Krishna S, White NJ. Plasmodium berghei: Lactic acidosis and hypoglycaemia in a rodent model of severe malaria; effects of glucose, quinine and dichloroacetate. Exp Parasitol 1991; 72: 123-133.
9. WHO. Severe and complicated malaria. Trans R Soc Med Hyg 1990; 84: 1-65.
10. White NJ, Krishna S. Treatment of Malaria: some considerations and limitations of current methods of assessment. Trans R Soc Med Hyg 1989; 83: 767-777.
11. Shapiro BA, Harrison RA, Walton JR. Clinical application of blood gases. Year Book Medical Publishers, 1982: 316.
12. White NJ, Warrell DA, Chantavanich P, et al. Severe hypoglycaemia and hyperinsulinaemia in falciparum malaria. N Engl J Med 1983; 309: 61-66.
13. Pukrittayamakamee S, White NJ, Davis TME, et al. Hepatic blood flow and metabolism in severe falciparum malaria: clearance of intravenously administered galactose. Clin Sci 1991; 82: 63-70.
14. Lupo M, Cefalu WT, Partridge WM. Kinetics of lactate transport into rat liver in vivo. Metabolism 1990; 39: 373-377.
15. Pukrittayakamee S, White NJ, Davis TME, et al. Glycerol metabolism in severe falciparum malaria. Metabolism 1994; 43: 887-892.
16. Holloway PA, Knox K, Bajaj N, et al. Plasmodium berghei infection: dichloroacetate improves survival in rats with lactic acidosis. Exp Parasitol 1995; 80: 624-632.
17. ter Kuile FO, White NJ, Holloway PA, Pasvol G, Krishna S. Plasmodium falciparum: In vitro studies of the pharmacodynamic properties of antimalarials used for the treatment of severe malaria. Exp Parasitol 1993; 76: 85-95.
18. Pukrittayakamee S, Supanaranond W, Looareesuwan S, Vanijanonta S, White NJ. Quinine in severe falciparum malaria: evidence of declining efficacy. Trans R Soc Med Hyg 1994; 88: 324-327.
19. Krishna S, Agbenyega T, Angus BJ, et al. Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria. Q J Med 1995; 88: 341-349.