Treatment of parainfluenza virus type 3 bronchiolitis and pneumonia in a cotton rat model using topical antibody and glucocorticosteroid

Journal of Infectious Diseases

Volumn 173, Issue 3, 1996, Pages 598-608

  Prince, Gregory A ^a   Porter, David D ^b  

^a Virion Systems Inc   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; GLUCOCORTICOID; IMMUNOGLOBULIN G; TRIAMCINOLONE ACETONIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHIOLITIS; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DRUG EFFECT; DRUG SCREENING; IMMUNOTHERAPY; NONHUMAN; PARAINFLUENZA VIRUS 3; PRIORITY JOURNAL; RAT; RNA VIRUS INFECTION; TOPICAL DRUG ADMINISTRATION; VIRUS PNEUMONIA;

EID: 0030040133     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/173.3.598     Document Type: Article

References (13)

1. McIntosh K, Chanock RM. Respiratory syncytial virus. In: Fields BN, Knipe DM, Chanock RM, et al., eds. Fields virology. 2nd ed. New York: Raven Press, 1990:1045-72.
2. Chanock RM, McIntosh K. Parainfluenza viruses. In: Fields BN, Knipe DM, Chanock RM, et al., eds. Fields virology. 2nd ed. New York: Raven Press, 1990:963-88.
3. Institute of Medicine. Prospects for immunizing against parainfluenza viruses and respiratory syncytial virus. In: New vaccine development. Establishing priorities. Vol 1. Washington, DC: National Academy Press, 1985:385-409.
4. Anderson LJ, Heilman CA. Protective and disease-enhancing immune responses to respiratory syncytial virus. J Infect Dis 1995;171:1-7.
5. Kim HW, Canchola JG, Brandt CD, et al. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol 1969; 89:422-34.
6. Meert KL, Sarnaik AP, Gelmini MJ, Lieh-Lai MW. Aerosolized ribavirin in mechanically ventilated children with respiratory syncytial virus lower respiratory tract disease: a prospective, double-blind, randomized trial. Crit Care Med 1994;22:566-72.
7. Smith DW, Frankel LR, Mathers LH, Tang ATS, Ariagno RL, Prober CG. A controlled trial of aerosolized ribavirin in infants receiving mechanical ventilation for severe respiratory syncytial virus infection. N Engl J Med 1991:325:24-9.
8. Groothuis JR, Simoes EAF, Levin MJ, et al. Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. N Engl J Med 1993;329:1524-30.
9. Hemming VG, Prince GA, Groothuis JR, Siber GR. Hyperimmune globulins in prevention and treatment of respiratory syncytial virus infections. Clin Microbiol Rev 1995; 8:22-33.
10. Prince GA, Jenson AB, Horswood RL, Camargo E, Chanock RM. The pathogenesis of respiratory syncytial virus infection in cotton rats. Am J Pathol 1978;93:771-91.
11. Porter DD, Prince GA, Hemming VG, Porter HG. Pathogenesis of human parainfluenza virus 3 infection in two species of cotton rats: Sigmodon hispidus develops bronchiolitis, while Sigmodon falviventer develops interstitial pneumonia. J Virol 1991;65:103-11.
12. Prince GA, Porter DD, Jenson AB, Horswood RL, Chanock RM, Ginsberg HS. Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus). J Virol 1993;67:101-11.
13. Ginsberg HS, Moldawer LL, Sehgal PB, et al. A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc Natl Acad Sci USA 1991;88:I651-5.