Cytochrome P450rm from Rhodotorula minuta catalyzes 4-hydroxylation of benzoate

Journal of Biochemistry

Volumn 119, Issue 2, 1996, Pages 314-318

  Fukuda, Hideo ^a   Nakamura, Kiminori ^a   Sukita, Eiki ^a   Ogawa, Takahira ^a   Fujii, Takao ^a  

^a SOJO UNIVERSITY   (Japan)

Author keywords

Benzoate 4 hydroxylase; Cytochrome P450; Formation of isobutene; P450rm; Rhodotorula minuta

Indexed keywords

3 OXOADIPIC ACID; ADIPIC ACID; AROMATIC COMPOUND; BENZOIC ACID; CARBOXYLIC ACID DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; ISOBUTYLENE; ISOVALERIC ACID; OXYGENASE; PHENYLALANINE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DEGRADATION; DISSOCIATION CONSTANT; HYDROXYLATION; MICROSOME; NONHUMAN; RHODOTORULA; TURNOVER TIME;

RHODOTORULA MINUTA;

EID: 0030039807     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021241     Document Type: Article

References (16)

1. Fujii, T., Ogawa, T., and Fukuda, H. (1989) The relationship between isobutene-forming activity and a cytochrome P450 in Rhodotorula minuta. J. Ferment. Bioeng. 68, 174-177
2. Fukuda, H., Ogawa, T., and Fujii, T. (1985) Production of isobutene by Rhodotorula yeasts. Agric. Biol. Chem. 49, 1541-1543
3. 5 from Rhodotorula minuta. Biosci. Biotech. Biochem. 57, 1599-1601
4. Fukuda, H., Fujii, T., Sukita, E., Tazaki, M., Nagahama, S., and Ogawa, T. (1994) Reconstitution of the isobutene-forming reaction catalyzed by cytochrome P450 and P450 reductase from Rhodotorula minuta. Biochem. Biophys. Res. Commun. 201, 516-522
5. Fujii, T., Ogawa, T., and Fukuda, H. (1992) Induction of cytochrome P450rm in Rhodotorula minuta by L-phenylalanine in Proceedings of 7th International Conference on Biochemistry and Biophysics of Cytochrome P450 (Archakov, A.I. and Bachmanova, G.I., eds.) pp. 516-518, INCO-TNC, Joint Stock Company, Moscow, Russia
6. Cook, K.A. and Cain, R.B. (1974) Regulation of aromatic metabolism in the fungi: Metabolic control of the 3-oxoadipate pathway in the yeast. J. Gen. Microbiol. 85, 37-50
7. Durham, D.R., Mcnamee, C.G., and Stewart, D.B. (1984) Dissimilation of aromatic compounds in Rhodotorula graminis: Biochemical characterization of pleiotropically negative mutants. J. Bacteriol. 160, 771-777
8. Harris, G. and Ricketts, R.W. (1962) Metabolism of phenolic compounds by yeasts. Nature 195, 473-474
9. Moore, K., Subba Rao, P.V., and Towers, G.H.N. (1968) Degradation of phenylalanine and tyrosine by Sporobolomyces roseus. Biochem. J. 106, 507-514
10. Cain, R.B., Bilton, R.F., and Darrah, J.A. (1968) The metabolism of aromatic acids by micro-organisms. Biochem. J. 106, 797-828
11. Jamaluddin, M., Subba Rao, P.V., and Vaidyanathan, C.S. (1970) Involvement of the protocatechuate pathway in the metabolism of mandelic acid by Aspergillus niger. J. Bacteriol. 101, 786-793
12. Gall, A. and Naujahr, H.Y. (1979) Metabolism of phenol and resorcinol in Trichosporon cutaneum. J. Bacteriol. 137, 13-21
13. Anderson, J.J. and Dagley, S. (1980) Catabolism of aromatic acids in Trichosporon cutaneum. J. Bacteriol. 141, 534-543
14. Imai, Y. and Sato, R. (1967) Studies on the substrate interaction with P-450 in drug hydroxylation by liver microsomes. J. Biochem. 62, 293-249
15. Reddy, C.C. and Vaidyanathan, C.S. (1975) Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus niger (UBC 814). Biochim. Biophys. Acta 384, 46-57
16. Gorcom, R.F.M., Boschloo, J.G., Kuijvenhoven, A., Lange, J., Vark, A.J., Bos, C.J., Balken, J.A.M., Pouwels, P.H., and Hondel, C.A.M.J.J. (1990) Isolation and molecular characterization of the benzoate-para-hydroxylase gene (bphA) of Aspergillus niger: A member of a new gene family of the cytochrome P450 superfamily. Mol. Gen. Genet. 223, 192-197