Amino acid residues on the I-Ak α-chain required for the binding and stability of two antigenic peptides

Journal of Immunology

Volumn 156, Issue 1, 1996, Pages 176-182

  Nelson, Christopher A ^a   Viner, Nicholas ^a   Young, Steven ^b   Petzold, Shirley ^a   Benoist, Christophe ^c   Mathis, Diane ^c   Unanue, Emil R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; HEAT SHOCK PROTEIN; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYBRIDOMA; L CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; T LYMPHOCYTE;

ALANINE; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ARGININE; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS II; L CELLS (CELL LINE); MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

EID: 0030039457     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Brown, J. H., T. S. Jardetzky, J C. Gorga, L. J. Stern, R G. Urban, J. L. Strominger, and D. C. Wiley 1993. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1 Nature 364 33
2. Stern, L. J., J. H. Brown, T S Jardetzky, J. C. Gorga, R. G. Urban, J. L. Strominger, and D. C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368:215.
3. Racioppi, L , F Ronchese, R. H Schwartz, and R. N. Germain. 1991. The molecular basis of class II MHC allelic control of T cell responses. J. Immunol. 147:3718.
4. Krieger, J. I., R. W. Karr, H. M. Grey, W Y Yu, D. O'Sullivan, L Batovsky, Z L Zheng, S. M. Colon, F. C. Gaeta, J. Sidney, et al. 1991. Single ammo acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition. J. Immunol. 146:2331.
5. Rosloniec, E. F., Beard, K. S., and Freed, J H. 1993 Functional analysis of the antigen binding region of an MHC class II molecule Mol Immunol. 30:491
6. Nelson, C. A., R W. Roof, D. W. McCourt and E. R Unanue. 1992. Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak. Proc Natl. Acad. Sci. USA 89.7380.
7. Lee, J M., D. J. McKean, and T. H. Watts. 1991. Functional mapping of MHC class II polymorphic residues, the alpha-chain controls the specificity for binding an A d- versus an A k-restricted peptide and the β-chain region 65-67 controls T cell recognition but not peptide binding. J. Immunol. 146:2952.
8. Dellabona, P., J. Peccoud, J Kappler, P Marrack, C. Benoist, and D. Mathis 1990. Superantigens interact with MHC class II molecules outside of the antigen groove. Cell 62:1115.
9. Peccoud, J., P. Dellabona, P. Allen, C. Benoist, and D. Mathis. 1990. Delineation of antigen contact residues on an MHC class II molecule EMBO J. 9:4215
10. Dornmair, K , B Rothenhausler, and H. M. McConnell. 1989 Structural intermediates in the reactions of antigenic peptides with MHC molecules. Cold Spring Harbor Symp. Quant Biol. 54(Pt. 1):409.
11. Germain, R. N., and L R. Hendrix. 1991. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding. Nature 353:134
12. Nelson, C. A., S. J. Petzold, and E. R. Unanue. 1994 Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell. Nature 371. 250.
13. Nelson, C. A , S J Petzold, and E. R. Unanue. 1993 Identification of two distinct properties of class II major histocompatibility complex-associated peptides. Proc. Natl. Acad. Sci. USA 90:1227
14. Oi, V. T., P P. Jones, J. W. Goding, L A. Herzenberg, and L. A. Herzenberg. 1978 Properties of monoclonal antibodies to mouse Ig allotypes. H-2, and Ia antigens. Curr Top. Microbiol. Immunol. 81:115
15. Lechler, R I., M A Norcross, and R. N. Germain. 1985. Qualitative and quantitative studies of antigen-presenting cell function by using I-A-expressing L cells. J Immunol. 135.2914
16. Lechler, R. I., F. Ronchese, N. S. Braunstein, and R. N Germain. 1986 I-A-restricted T cell antigen recognition. J. Exp. Med. 163.678
17. Glimcher, L. H., D. J. McKean, E Choi, and J. C. Seidman. 1985. Complex regulation of class II gene expression: analysis with class II mutant cell lines. J. Immunol. 135:3542.
18. k protein. Proc Natl. Acad. Sci. USA 86.6297
19. Pierres, M., C. Devaux, M. Dosseto, and S. Marchetto. 1981. Clonal analysis of B- and T-cell responses to Ia antigens 1. Topology of epitope regions on I-Ak and I-Ek molecules analyzed with 35 monoclonal alloantibodies. Immunogenetics 14.481.
20. Landias, D., B. N Beck, J. M Buerstedde, S Degraw, D Klein, N Koch, D Murphy, M Pierres, T. Tada, K Yamamoto, et al 1986. The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants. J. Immunol. 137:3002.
21. Brooks, B R., R. E. Bruccoleri, B. D. Olafson, D. J States, S. Swaminathan, and M Karplus 1983. CHARMM: a program for macromolecular energy minimization and dynamics calculations. J Comp Chem 4.187.
22. Kabat, E A , T T Wu, H M. Perry, K S. Gottesman, and C Foeller 1991. Sequences of Proteins of Immunological Interest, 5th Ed NIH Publication 1 838. U. S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, MD.
23. Allen, P. M., G R. Matsueda, R J. Evans, J. B. Dunbar, Jr. G. R. Marshall, and E. R. Unanue 1987 Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope. Nature 327:713.
24. Brown, J. H , T. Jardetzky, M. A. Saper, B. Samraoui, P. J Bjorkman, and D C. Wiley. 1988 A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules. Nature 332:845.