메뉴 건너뛰기




Volumn 10, Issue 6, 1996, Pages 984-990

DNA-binding domain of AML1, expressed in t(8;21) and t(3;21) myeloid leukemias, inhibits PEBP2/CBF DNA-binding but is not sufficient to transform 32D cl3 myeloid cells

Author keywords

AML1; Differentiation; Leukemia; Myeloid

Indexed keywords

DNA BINDING PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 3; MUTANT PROTEIN; ONCOPROTEIN; TRANSCRIPTION FACTOR;

EID: 0030038668     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (34)
  • 1
    • 0025039291 scopus 로고
    • Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer
    • Kamachi Y, Ogawa E, Asano M, Ishida S, Murakami Y, Satake M, Ito Y, Shigesada K. Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J Virol 1990; 64: 4808-4819.
    • (1990) J Virol , vol.64 , pp. 4808-4819
    • Kamachi, Y.1    Ogawa, E.2    Asano, M.3    Ishida, S.4    Murakami, Y.5    Satake, M.6    Ito, Y.7    Shigesada, K.8
  • 2
    • 0026643904 scopus 로고
    • Differential expression of subspecies of polyomavirus and murine leukemia virus enhancer core binding protein, PEBP2, in various hematopoietic cells
    • Satake M, Inuzuka M, Shigesada K, Oikawa T, Ito Y. Differential expression of subspecies of polyomavirus and murine leukemia virus enhancer core binding protein, PEBP2, in various hematopoietic cells. Jpn J Cancer Res 1992; 83: 714-722.
    • (1992) Jpn J Cancer Res , vol.83 , pp. 714-722
    • Satake, M.1    Inuzuka, M.2    Shigesada, K.3    Oikawa, T.4    Ito, Y.5
  • 3
    • 0026502459 scopus 로고
    • Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers
    • Wang S, Speck NA. Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers. Mol Cell Biol 1992; 12: 89-102.
    • (1992) Mol Cell Biol , vol.12 , pp. 89-102
    • Wang, S.1    Speck, N.A.2
  • 5
    • 0027184229 scopus 로고
    • Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α
    • Ogawa E, Inuzuka M, Maruyamna M, Satake M, Naito-Fujimoto M, Ito Y, Shigesada K. Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 1993; 194: 314-331.
    • (1993) Virology , vol.194 , pp. 314-331
    • Ogawa, E.1    Inuzuka, M.2    Maruyamna, M.3    Satake, M.4    Naito-Fujimoto, M.5    Ito, Y.6    Shigesada, K.7
  • 6
    • 0027220003 scopus 로고
    • PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
    • Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, Shigesada K, Ito Y. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci USA 1993; 90: 6859-6863.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6859-6863
    • Ogawa, E.1    Maruyama, M.2    Kagoshima, H.3    Inuzuka, M.4    Lu, J.5    Satake, M.6    Shigesada, K.7    Ito, Y.8
  • 7
    • 0027256023 scopus 로고
    • Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
    • Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 1993; 13: 3324-3339.
    • (1993) Mol Cell Biol , vol.13 , pp. 3324-3339
    • Wang, S.1    Wang, Q.2    Crute, B.E.3    Melnikova, I.N.4    Keller, S.R.5    Speck, N.A.6
  • 9
    • 0027383818 scopus 로고
    • Identification of AML1 and the (8.21) translocation protein AML1-ETO as sequence specific DNA binding proteins: The runt homology domain is required for DNA binding and protein-protein interactions
    • Meyers S, Downing JR, Hiebert SW. Identification of AML1 and the (8.21) translocation protein AML1-ETO as sequence specific DNA binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol 1993; 13: 6336-6345.
    • (1993) Mol Cell Biol , vol.13 , pp. 6336-6345
    • Meyers, S.1    Downing, J.R.2    Hiebert, S.W.3
  • 12
    • 0025746321 scopus 로고
    • t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
    • Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci USA 1991; 88: 10431-10434.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10431-10434
    • Miyoshi, H.1    Shimizu, K.2    Kozu, T.3    Maseki, N.4    Kaneko, Y.5    Ohki, M.6
  • 13
    • 0026496547 scopus 로고
    • Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells
    • Nisson PE, Watkins PC, Sacchi N. Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. Cancer Genet Cytogenet 1992; 63: 81-88.
    • (1992) Cancer Genet Cytogenet , vol.63 , pp. 81-88
    • Nisson, P.E.1    Watkins, P.C.2    Sacchi, N.3
  • 14
    • 0026757174 scopus 로고
    • Identification of breakpoints in t8.211 acute myeloid leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
    • Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley JH, Drabkin H. Identification of breakpoints in t(8.211 acute myeloid leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 1992; 80: 1825-1831.
    • (1992) Blood , vol.80 , pp. 1825-1831
    • Erickson, P.1    Gao, J.2    Chang, K.S.3    Look, T.4    Whisenant, E.5    Raimondi, S.6    Lasher, R.7    Trujillo, J.8    Rowley, J.H.9    Drabkin, H.10
  • 15
    • 0027183945 scopus 로고
    • The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER1
    • Nucifora G, Begy CR, Erickson P, Drabkin HA, Rowley JD. The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER1. Proc Natl Acad Sci USA 1993; 90: 7784-7788.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7784-7788
    • Nucifora, G.1    Begy, C.R.2    Erickson, P.3    Drabkin, H.A.4    Rowley, J.D.5
  • 16
    • 0028069226 scopus 로고
    • Generation of the AML1/Evi-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis of chronic myelocytic leukemia
    • Mitani K, Ogawa S, Miyoshi H, Mano H, Yazaki Y, Ohki M, Hirai H. Generation of the AML1/Evi-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis of chronic myelocytic leukemia. EMBO J 1994; 13: 504-510.
    • (1994) EMBO J , vol.13 , pp. 504-510
    • Mitani, K.1    Ogawa, S.2    Miyoshi, H.3    Mano, H.4    Yazaki, Y.5    Ohki, M.6    Hirai, H.7
  • 17
    • 0028170592 scopus 로고
    • AML1 fusion transcripts in t(3;21) positive leukemia. Evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts
    • Sacchi N, Nisson PE, Watkins PC, Faustinella F, Wijsman J, Hagemeijer A. AML1 fusion transcripts in t(3;21) positive leukemia. Evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts. Genes Chromosoms Cancer 1994; 11: 226-236.
    • (1994) Genes Chromosoms Cancer , vol.11 , pp. 226-236
    • Sacchi, N.1    Nisson, P.E.2    Watkins, P.C.3    Faustinella, F.4    Wijsman, J.5    Hagemeijer, A.6
  • 18
    • 0026728034 scopus 로고
    • Quantitative acute leukemia cytogenetics
    • Mitelman F, Heim S, Quantitative acute leukemia cytogenetics. Genes Chromosoms Cancer 1992; 5: 57-66.
    • (1992) Genes Chromosoms Cancer , vol.5 , pp. 57-66
    • Mitelman, F.1    Heim, S.2
  • 19
    • 0027218725 scopus 로고
    • The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
    • Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J 1993; 2: 2715-2721.
    • (1993) EMBO J , vol.2 , pp. 2715-2721
    • Miyoshi, H.1    Kozu, T.2    Shimizu, K.3    Enomoto, K.4    Maseki, N.5    Kaneko, Y.6    Kamada, N.7    Ohki, M.8
  • 20
    • 0028136090 scopus 로고
    • Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative(8) chromosome in the t(8.21) of acute myeloid leukemia M2
    • Tighe JE, Calabi F. Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative(8) chromosome in the t(8.21) of acute myeloid leukemia M2. Blood 1994; 84: 2115-2121.
    • (1994) Blood , vol.84 , pp. 2115-2121
    • Tighe, J.E.1    Calabi, F.2
  • 21
    • 0020538097 scopus 로고
    • Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines
    • Greenberger JS, Sakaeeny M, Humphries RK, Eaves CJ, Eckner RJ. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc Natl Acad Sci USA 1983; 80: 2931-2935.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 2931-2935
    • Greenberger, J.S.1    Sakaeeny, M.2    Humphries, R.K.3    Eaves, C.J.4    Eckner, R.J.5
  • 23
    • 0028066779 scopus 로고
    • PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
    • Nuchprayoon I, Meyers S, Scott LM, Suzow J, Hiebert S and Friedman AD. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol Cell Biol 1994; 14: 5558-5568.
    • (1994) Mol Cell Biol , vol.14 , pp. 5558-5568
    • Nuchprayoon, I.1    Meyers, S.2    Scott, L.M.3    Suzow, J.4    Hiebert, S.5    Friedman, A.D.6
  • 24
    • 0027984233 scopus 로고
    • Identification of a region which directs the monocytic activity of the CSF-1 (M-CSF) receptor promoter and binds PEBP2/CBF (AML1)
    • Zhang DE, Ken-Ichiro F, Hetherington CJ, Shapiro LH, Chen HM, Look TA, Tenen DC. Identification of a region which directs the monocytic activity of the CSF-1 (M-CSF) receptor promoter and binds PEBP2/CBF (AML1). Mol Cell Biol 1994; 14: 8085-8095.
    • (1994) Mol Cell Biol , vol.14 , pp. 8085-8095
    • Zhang, D.E.1    Ken-Ichiro, F.2    Hetherington, C.J.3    Shapiro, L.H.4    Chen, H.M.5    Look, T.A.6    Tenen, D.C.7
  • 25
    • 0014594486 scopus 로고
    • A transplantable myelomonocytic leukemia in Balb/c mice: Cytology, karyotype, and murimadase activity
    • Warner NL, Moore MAS, Metcalf D. A transplantable myelomonocytic leukemia in Balb/c mice: cytology, karyotype, and murimadase activity. J Natl Cancer Inst 1969; 43: 963-982.
    • (1969) J Natl Cancer Inst , vol.43 , pp. 963-982
    • Warner, N.L.1    Moore, M.A.S.2    Metcalf, D.3
  • 26
    • 0026758202 scopus 로고
    • A novel expression pattern of three C/EBP family members in differentiating myelomonocytic cells
    • Scott LM, Civin CI, Rorth P, Friedman AD. A novel expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 1992; 80: 1725-1735.
    • (1992) Blood , vol.80 , pp. 1725-1735
    • Scott, L.M.1    Civin, C.I.2    Rorth, P.3    Friedman, A.D.4
  • 27
    • 0342463159 scopus 로고
    • Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges
    • Danos O, Mulligan RC. Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc Natl Acad Sci USA 1988; 85: 6460-6464.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6460-6464
    • Danos, O.1    Mulligan, R.C.2
  • 28
    • 0025352187 scopus 로고
    • Advanced mammalian gene transfer: High titre retroviral receptors with multiple durg selection markers and a complementary helper-free packaging cell line
    • Morgenstern JP, Land H. Advanced mammalian gene transfer: high titre retroviral receptors with multiple durg selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 1990; 18: 3587-3596.
    • (1990) Nucleic Acids Res , vol.18 , pp. 3587-3596
    • Morgenstern, J.P.1    Land, H.2
  • 29
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Digram JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983; 11: 1475-1489.
    • (1983) Nucleic Acids Res , vol.11 , pp. 1475-1489
    • Digram, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 30
    • 0028209966 scopus 로고
    • Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting
    • Cameron S, Taylor DS, TePas EC, Speck NA, Mathey-Prevot B. Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting. Blood 1994; 83: 2851-2859.
    • (1994) Blood , vol.83 , pp. 2851-2859
    • Cameron, S.1    Taylor, D.S.2    TePas, E.C.3    Speck, N.A.4    Mathey-Prevot, B.5
  • 31
    • 0028837972 scopus 로고
    • An acute myeloid leukemia gene, AML1, regulates hematopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms
    • Tanaka T, Tanaka K, Ogawa S, Kurokawa M, Mitani K, Nishida J, Shibata Y, Yazaki Y, Hirai H. An acute myeloid leukemia gene, AML1, regulates hematopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms. EMBO J 1995; 14: 341-350.
    • (1995) EMBO J , vol.14 , pp. 341-350
    • Tanaka, T.1    Tanaka, K.2    Ogawa, S.3    Kurokawa, M.4    Mitani, K.5    Nishida, J.6    Shibata, Y.7    Yazaki, Y.8    Hirai, H.9
  • 32
    • 0027395118 scopus 로고
    • The murine myeloperoxidase promoter contains several functional elements - One element binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1)
    • Suzow J, Friedman AD. The murine myeloperoxidase promoter contains several functional elements - one element binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1). Mol Cell Biol 1993; 13: 2141-2151.
    • (1993) Mol Cell Biol , vol.13 , pp. 2141-2151
    • Suzow, J.1    Friedman, A.D.2
  • 34
    • 0028925282 scopus 로고
    • The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation
    • Meyers S, Lenny N, Hiebert SW. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol 1995; 15: 1974-1982.
    • (1995) Mol Cell Biol , vol.15 , pp. 1974-1982
    • Meyers, S.1    Lenny, N.2    Hiebert, S.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.