Nonpeptide angiotensin II receptor antagonist: Pharmacokinetics and pharmacodynamics in rats of EXP3174, an active metabolite of losartan

Pharmacology

Volumn 52, Issue 1, 1996, Pages 25-29

  Wong, Pancras C ^a   Christ, David D ^b   Wong, Y Nancy ^b   Lam, Gilbert N ^b  

^a Sections of Prcclinical Pharmacology   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

Angiotensin II receptor antagonist; Blood pressure; Hypertension; Losartan; Renin angiotensin system

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; LOSARTAN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PLASMA PROTEIN BINDING; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT;

EID: 0030038502     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139357     Document Type: Article

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