Analysis of immunoglobulin variable region genes of a human IgM anti-myeloperoxidase antibody derived from a patient with vasculitis

Immunology

Volumn 87, Issue 2, 1996, Pages 334-338

  Longhurst, C ^a   Ehrenstein, M R ^a   Leaker, B ^a   Stevenson, F K ^b   Spellerberg, M ^b   Chapman, C ^b   Latchmen, D ^a   Isenberg, D A ^a   Cambridge, G ^a,c  

^a MIDDLESEX HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^c Division of Rheumatology   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; MYELOPEROXIDASE;

AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE; NUCLEOTIDE SEQUENCE; POLYARTERITIS; PRIORITY JOURNAL; VASCULITIS;

EID: 0030038484     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1996.463529.x     Document Type: Article

References (22)

1. KALLENBERG C.G.M., BROUWER E., WEENING J.J. & COHEN TERVAERT J.W. (1994) Anti-neutrophil cytoplasmic antibodies: current diagnostic and pathophysiological potential. Kidney Int 46, 1.
2. ROBERTS D.E., PEEBLES C., CURD J.G., TAN E.M. & RUBIN R.L. (1991) Autoantibodies to native myeloperoxidase in patients with pulmonary haemorrhage and acute renal failure. J Clin Immunol 6, 389.
3. FALK R.J., BECKER M., TERRELL R. & JENNETTE J.C. (1992) Anti-myeloperoxidase antibodies react with native but not denatured myeloperoxidase. Clin Exp Immunol 89, 274.
4. EWERT B.H., JENNETTE J.C. & FALK R.J. (1992) Anti-myeloperoxidase antibodies stimulate neutrophils to damage endothelial cells. Kidney Int 41, 375.
5. FALK R.J., HOGAN S., CaREY T.S. & JENNETTE J.C. (1990) Clinical course of anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and systemic vasculitis. The Glomerular Disease Collaborative Network. Annu Intern Med 113, 656.
6. ROSSI F., JAYNE D.R.W., LOCKWOOD C.M. & KAZATCHKINE M.D. (1991) Anti-idiotypes against anti-neutrophil cytoplasmic antigen autoantibodies in normal human polyspecific IgG for therapeutic use and in the remission sera of patients with systemic vasculitis. Clin Exp Immunol 83, 298.
7. RADIC M.Z., MASCELLI A., ERICKSON J., SHAW H & WEIGERT M (1992) IgH and Igt. chain contribution to autoimmune specificities. J Immunol 146, 176.
8. EHRENSTEIN M.R., LEAKER B., ISENBERG D.A. & CAMBRIDGE G. (1992) Production of human monoclonal antibodies to myeloperoxidase. Immunology 76, 617.
9. HUNDER G.G., AREND W.P. & BLOCH D.A., et al. (1990) The American College of Rheumatology 1990 criteria for the classification of vasculitis. Arthritis Rheum 33, 1065.
10. CAMBRIDGE G., WILLIAMS M., LEAKER B., CORBETT M. & SMITH C.R. (1994) Anti-myeloperoxidase antibodies in patients with rheumatoid arthritis: prevalence, clinical correlates and IgG subclass. Annu Rheum Dis 53, 24.
11. CHIRGWIN J.M., PRZBYLA A.E., MACDONALD R.J.H. & RUTTER W.J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294.
12. KAWASAKI E. (1990) Amplification of RNA. In: PCR Protocols: A Guide to Methods and Applications (M.A. Innis, J. Sninsky & T.J. White, eds), p. 21. Academic Press, California.
13. H4.21 gene segment by anti-DNA antibodies from patients with SLE. J Autoimm 6, 809.
14. H genes are inherently susceptable to amino acid replacement. Immunol Today 15, 367.
15. H4.21 gene segment is required to encode anti-I and anti-i specificities. J Immunol 149, 2337.
16. JaYNE D.R.W., JONES S.J., SEVERN A., SHAUNAK S., MURPHY J. & LOCKWOOD C.M. (1989) Severe pulmonary haemorrhage and systemic vasculitis in association with circulating anti-neutrophil antibodies of the IgM class only. Clin Nephrol 32, 101.
17. STEVENSON F.K., WRIGHTHAM N., GLENNIE M.J. et al. (1986) Antibodies to shared idiotypes as agents for analysis and therapy for human B cell tumors. Blood 68, 430.
18. ISENBERG D.A., SPELLERBERG M.B., WILLIAMS W., GRIFFITHS M. & STEVENSON F.K. (1993) Identification of a role for the 9G4 idiotype in systemic lupus erythematosus. Br J Rheum 32, 876.
19. H gene overrepresented in the autoimmune repertoire. Arthritis Rheum 35, 11.
20. SCHWARTZ R.S. & STOLLAR B.D. (1994) Heavy chain directed B-cell maturation: continuous clonal selection beginning at the pre-B cell stage. Immunol Today 15, 27.
21. H4.21 gene segment. J Exp Med 178, 1419.
22. RADIC M.Z., MACKLE J., ERIKSON J., MOL C., ANDERSON W.F. & WEIGART M. (1993) Residues that mediate DNA binding of autoimmune antibodies. J Immunol 150, 4966.