Antagonism by SR 48692 of mechanical responses to neurotensin in rat intestine

British Journal of Pharmacology

Volumn 117, Issue 3, 1996, Pages 488-492

  Mule F ^a   Serio, R ^a   Postorino, A ^a   Vetri, T ^a   Bonvissuto, F ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Neurotensin; Neurotensin intestinal effects; Neurotensin receptors; Non peptide neurotensin antagonist; SR 48692

Indexed keywords

2 [[1 (7 CHLORO 4 QUINOLINYL) 5 (2,6 DIMETHOXYPHENYL) 3 PYRAZOLYL]CARBONYLAMINO] 2 ADAMANTANECARBOXYLIC ACID; CARBACHOL; NEUROTENSIN; NEUROTENSIN ANTAGONIST; NEUROTENSIN RECEPTOR; NORADRENALIN; SUBSTANCE P; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ASCENDING COLON; COMPETITIVE INHIBITION; CONTROLLED STUDY; DUODENUM; INTESTINE; INTESTINE MUSCLE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION;

EID: 0030038469     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15216.x     Document Type: Article

References (24)

1. AL SAFFAR, A. & ROSELL, S. (1981). Effects of neurotensin and neurotensin analogues on the myoelectrical complexes in the small intestine of rats. Acta Physiol. Scand., 112, 203-208.
2. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 48-58.
3. BEHBEHANI, M.M. (1992). Physiological mechanisms of the analgesic effect of neurotensin. Ann. N. Y. Acad. Sci., 668, 253-265.
4. BISSETTE, G., NEMEROFF, C.B., LOOSEN, P.T., PRANGE, A.J. Jr. & LIPTON, M.A. (1976). Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin. Nature, 262, 607-609.
5. BUCHAN, A.M.J. & BARBER, D.L. (1987). Neurotensin containing neurons in the canine enteric innervation. Neurosci. Lett., 76, 13-17.
6. COCHRANE, D.E. (1990). Peptide regulation of mast cell function. Prog. Med. Chem., 27, 143-188.
7. DUBUC, I., COSTENTIN, J., TERRANOVA, J.P., BARNOUIN, M.C. SOUBRIÈ, P., LEFUR, G., ROSTENE, W. & KITABGI, P. (1994). The nonpeptide neurotensin antagonist. SR 48692, used as a tool to reveal putative neurotensin receptor subtypes. Br. J. Pharmacol., 112, 352-354.
8. FERRIS, C.F. (1989). Neurotensin. In Handbook of Physiology, Section 6. The Gastrointestinal System, Vol. II: Neural and Endocrine Biology. ed. Schultz, S.G. & Makhlouf, G.M. pp 559-586. Bethesda: American Physiological Society.
9. GOEDERT, M., HUNTER, J.C. & NINKOVIC, M. (1984). Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea-pig ileum. Nature, 311, 59-62.
10. GULLY, D., CANTON, M., BOIGEGRAIN, R., JEANJEAN, F., MOLIMARD, J.C., PONCELET, M., GUEUDET, C., HEAULME, M., LEYRIS, R., BROUARD, A., PEUAPRAT, D., LABBÈ-JULLIÈ, C., MAZELLA, J., SOUBRIÈ, P., MAFFRAND, J.P., ROSTENE, W., KITABGI, P. & LE FUR, G. (1993). Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Proc. Natl. Acad. Sci. USA, 90, 65-69.
11. HALL, J.M., CAULFIELD, M.P., WATSON, S.P. & GUARD, S. (1993). Receptors subtypes or species homologues: relevance to drug discovery. Trends Pharmacol. Sci., 14, 376-383.
12. KASCKOW, J. & NEMEROFF, C.B. (1991). The neurobiology of neurotensin: focus on neurotensin-dopamine interactions. Regul. Pept., 36, 153-164.
13. KITABGI, P., CHECLER, F., MAZELLA, J. & VINCENT, J.P. (1985). Pharmacology and biochemistry of neurotensin receptors. Rev. Clin. Basic Pharmacol., 5, 397-486.
14. KOMORI, S., FUKUTOME, T. & OHASHI, H. (1986). Isolation of a peptide material showing strong rectal muscle-contracting activity from chicken rectum and its identification as chicken neurotensin. Jpn. J. Pharmacol., 40, 577-589.
15. KOMORI, S., MATSUOKA, T., KWON, S.C., TAKEWAKI, T. & OHASHI, H. (1992). Membrane potential and current responses to ncurotensin in the longitudinal muscle of the rectal of the fowl. Br. J. Pharmacol., 107, 790-796.
16. LABBÉ-JULLIÉ, C., DESCHAINTRES, S., GULLY, D., LE FUR, G. & KITABGI, P. (1994a). Effect of the nonpeptide neurotensin antagonist, SR 48692, and two enantiomeric analogs, SR 48527 and SR 49711, on ncurotensin binding and contractile responses in guinea-pig ileum and colon. J. Pharmacol. Exp. Ther., 271, 267-276.
17. LABBÉ-JULLIÉ, C., DUBUC, I., BROUARD, A., DOULUT, S., BOURDEL, E., PELAPRAT, D., MAZELLA, J., MARTINEZ, J., ROSTENE, W., COSTENTIN, J. & KITABGI, P. (1994b). In vivo and in vitro structure-activity studies with peptide and pseudopeptide neurotensin analogs suggest the existence of distinct central neurotensin receptor subtypes. J. Pharmacol. Exp. Ther., 268, 328-336.
18. MILLER, L.A., COCHRANE, D.E., CARRAWAY, R.E. & FELDBERG, R.S. (1995). Blockade of mast cell histamine secretion in response to neurotensin by SR 48692, a nonpeptide antagonist of the neurotensin brain receptor. Br. J. Pharmacol., 114, 1466-1470.
19. MULE, F., POSTORINO, A., GERACT, A. & SERIO, R. (1992). Neurotensin: dual effect on the motor activity of rat duodenum. Eur. J. Pharmacol., 212, 215-224.
20. MULÈ, F., SERIO, R. & POSTORINO, A (1995). Motility pattern of isolated rat proximal colon and excitatory action of neurotensin. Eur. J. Pharmacol., 275, 131-137.
21. PRANGE, A.J. jr., (1992). The manifold actions of neurotensin, a trophotropic agent. Ann. N. Y. Acad. Sci., 668, 298-306.
22. ROSTENE, W., BROUARD, A., DANA, C., MASUO, Y., AGID, F., VIAL, M., LHIAUBET, A.M. & PELAPRAT, D. (1992). Interaction between neurotensin and dopamine in the brain. Morphofunctional and clinical evidence. Ann. N. Y. Acad. Sci., 668, 217-231.
23. SCHULTZBERG, M., HOKFELT, T., NILSSON, G., TERENIUS, L., REHFELD, J.F., BROWN, M., ELDE, R., GOLDSTEIN, M. & SAID, S. (1980). Distribution of peptide and catecholamine-containing neurons in the gastrointestinal tract of rat and guinea-pig: Immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin gastrin/cholecystokinin, neurotensin and dopamine-β-hydroxylase. Neuroscience, 5, 689-744.
24. SUNDLER, F.R., HAKANSON, R.A., HAMMER, J., ALUMETS, R., CARRAWAY, S.E., LEEMAN, S.E. & ZIMMERMAN, E.A. (1977). Immunohistochemical localization of neurotensin in endocrine cells of the gut. Cell. Tissue. Res., 178, 313-321.