메뉴 건너뛰기




Volumn 61, Issue 15, 1996, Pages 5180-5185

An efficient synthesis of cyclic RGD peptides as antithrombotic agents

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT; CYCLOPEPTIDE;

EID: 0030038270     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9603284     Document Type: Article
Times cited : (7)

References (24)
  • 14
    • 15844382173 scopus 로고    scopus 로고
    • note
    • THF or methylene chloride are typically used solvents.
  • 15
    • 15844396636 scopus 로고    scopus 로고
    • note
    • Isolation of a dry solid was only possible by addition of an ethyl acetate solution of 13 to a large excess of tert-butyl methyl ether at low temperature (-15 to 20°C).
  • 16
    • 15844365713 scopus 로고    scopus 로고
    • note
    • Initially, the HCl salt precipitation was unsuccessful in either dioxane or toluene due to the residual DCHA, because the free base of D-Abu had not been used. Once this was recognized and rectified, the HCl salt was easily produced as long as both water and ethyl acetate were removed via initial azeotropic distillation with dioxane.
  • 19
    • 0004249010 scopus 로고
    • Principles of Peptide Synthesis
    • Hafner, K., et al., Eds.; Springler-Verlag, Berling
    • Bodanszky, M. Principles of Peptide Synthesis; Reactivity and Structure Concepts in Organic Chemistry, Hafner, K., et al., Eds.; Springler-Verlag, Berling, 1984; Vol. 16, pp 137-141.
    • (1984) Reactivity and Structure Concepts in Organic Chemistry , vol.16 , pp. 137-141
    • Bodanszky, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.