Mechanisms by which HLA-class II molecules protect human B lymphoid tumour cells against NK- and LAK-mediated cytolysis

Immunology

Volumn 88, Issue 4, 1996, Pages 625-629

  Lobo, P I ^a   Chang, M Y ^b   Mellins, E ^c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2;

ADULT; ARTICLE; B LYMPHOCYTE; CELL LINE; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; LYMPHOKINE ACTIVATED KILLER CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MUTATION; NATURAL KILLER CELL; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0030038088     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1996.d01-679.x     Document Type: Article

References (16)

1. KARRE K., LJUNGGREN H.G., PIONTEK G. & KIESSLING R. (1986) Selective rejection of H-2 deficient lymphoma variants suggests alternative immune defense strategy. Nature 319, 675.
2. STORKUS W.J., HOWELL D.M., SALTER R.D., DAWSON J.R. & CRESSWELL P. (1987) NK susceptibility varies inversely with target cell class I HLA expression. J Immunol 138, 1657.
3. STORKUS W.J. & DAWSON J.R. (1991) Target structures involved in NK killing: characteristics, distribution and candidate molecules. Crit Rev Immunol 10, 393.
4. STORKUS W.J., ALEXANDER J., PAYNE J.A., CRESSWELL P. & DAWSON J.R. (1989) Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes. Proc Natl Acad Sci USA 86, 2361.
5. MORETTA A., VITALE M., BOTTINO C. et al. (1993) P58 molecules as putative receptors for MHC Class I molecules in human NK cells. Anti-p58 antibodies reconstitute lysis of MHC Class I protected cells in NK clones displaying different specificities. J Exp Med 178, 597.
6. GUMPERZ J.E., LITWIN V., PHILLIPS J.H., LANIER L.L. & PARHAM P. (1995) The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. J Exp Med 181, 1133.
7. LOBO P.I. & PATEL H.C. (1994) A novel role for MHC Class II antigens: evidence implicating a protective effect on tumour cells against cytotoxicity by NK and LAK cells. Immunology 83, 240.
8. MELLINS E., SMITH L., ARP B., CORTNER T., CELIS E. & PIOUS D. (1990) Defective processing and presentation of exogenous antigens in mutants with normal HLA-Class II genes. Nature 343, 71.
9. MELLINS E., WOELFEL M. & PIOUS D, (1987) Importance of HLA-DQ and DP restriction elements in T-cell responses to soluble antigens: mutational analysis. Hum Immunol 18, 211.
10. PIOUS D., DIXON L., LEVIN F., COTNER T. & JOHNSON R. (1985) HLA Class II regulation and structure. Analysis of HLA-DR3 and HLA-DP point mutants. J EXp Med 162, 1193.
11. LEVINE F., ERLICH H., MACH B., LEACH R., WHITE R. & PIORS D. (1985) Deletion mapping of HLA and chromosome 6p genes. Proc Natl Acad Sci USA 82, 3741.
12. MELLINS E., ARP B., SINGH D. et al. (1990) Point mutations define positions in HLA-DR3 molecules that affect antigen presentation. Proc Natl Acad Sci USA 87, 4785.
13. MELLINS E., CAMERON P., AMAYA M. et al. (1994) A mutant human histocompatibility leucocyte antigen DR molecule associated with invariant chain peptides. J Exp Med 179, 541.
14. GOODMAN S., SAWADA T., BARBOSA J.A. et al. (1995) Mutational analysis of two DR alpha residues involved in dimers of HLA-DR molecules. J Immunol 155, 1210.
15. KAUFMAN D.S., SCHOON R.A. & LEIBSON P.J. (1992) Role for major histocompatibility complex Class I in regulating natural killer cell mediated killing of virus infected cells. Proc Natl Acad Sci USA 89, 8337.
16. CHADWICK B.S. & MILLER R.G. (1992) Hybrid resistance in-vitro. Possible role of both Class I MHC and self peptides in determining the level of target sensitivity. J Immunol 148, 2307.