Leuchtenberger bodies in flat adenomas of the colorectal mucosa: A comparison between Japanese and Swedish patients

Japanese Journal of Cancer Research

Volumn 87, Issue 6, 1996, Pages 618-622

  Rubio, Carlos A ^a   Kumagai, Jiro ^b   Nakamura, Kyoichi ^b   Yanagisawa, Akio ^c   Kato, Yo ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c CANCER INSTITUTE   (Japan)

Author keywords

Apoptosis; Flat colorectal adenoma

Indexed keywords

DNA; DNA FRAGMENT;

ADENOMA; APOPTOSIS; ARTICLE; CELL INCLUSION; COLORECTAL CANCER; COMPARATIVE STUDY; DNA DAMAGE; DYSPLASIA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOPEROXIDASE STAINING; JAPAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SWEDEN; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0030037529     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1996.tb00268.x     Document Type: Article

References (17)

1. Leuchtenberger, C. Cytoplasmic "inclusion bodies" containing desoxyribose nucleic acid (DNA) in cells of human rectal polyps. Lab. Invest., 3, 132-142 (1954).
2. Leuchtenberger, C., Leuchtenberger, R. and Lieb, E. Studies of the cytoplasmatic inclusions containing desoxyribose nucleic acid (DNA) in human rectal polypoid tumors including the familial hereditary type. Acta Genet., 6, 291-297 (1956)
3. Fisher, E. R. and Sharkey, D. A. The ultrastructure of colonic polyps and cancer with special reference to the epithelial inclusion bodies of Leuchtenberger. Cancer, 15, 160-170 (1962).
4. Walb, D. and Sandritter, W. Inclusion bodies in rectal polyps. Arch. Pathol., 78, 104-107 (1964).
5. Rubio, C. A., Alm, T., Aly, A. and Poppen, B. Intraepithelial bodies in colorectal adenomas : Leuchtenberger bodies revisited. Dis. Colon Rectum, 34, 47-50 (1991).
6. Stewart, B. W. Mechanisms of apoptosis : integration of genetic, biochemical and cellular indicators. J. Natl. Cancer Inst., 86, 1286-1295 (1994).
7. Rubio, C. A., Kumagai, J., Kanamori, M., Yanagisawa, A., Nakamura, K. and Kato, Y. Flat adenomas and flat adenocarcinomas of the colorectal mucosa in Japanese and Swedish patients : a comparative histologic study. Dis. Colon Rectum, 38, 1075-1079 (1995).
8. Muto, T., Kamiya, T., Sawada, T., Konishi, F., Sugihara, K., Kubota, Y., Adachi, M., Agawa, S., Saito, Y., Morioka, Y. and Tanprayoon, T. Small "flat adenoma" of the bowel with special reference to its clinicopathological features. Dis. Colon Rectum, 28, 847-851 (1985).
9. Wolber, R. and Owen, D. A. Flat adenomas of the colon. Hum. Pathol., 22, 70-75 (1991).
10. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119, 493-501 (1992).
11. Muto, T., Bussey, H. J. and Morson, B. C. The evolution of cancer of the colon and rectum. Cancer, 36, 2251-2270 (1975).
12. Arai, T. and Kino, I. Role of apoptosis in modulation of the growth of human colorectal tubular and villous adenomas. J. Pathol., 176, 37-44 (1995).
13. Yamagata, S., Muto, T., Uchida, Y., Masaki, T., Sawada, T., Tsuno, N. and Hirooka, T. Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas. Jpn. J. Cancer Res., 85, 147-151 (1994).
14. Minamoto, T., Sawaguchi, K., Mai, M., Yamashita, N., Sugimura, T. and Esumi, H. Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas. Cancer Res., 54, 2841-2844 (1994).
15. Rubio, C. A. and Rodensjö, M. Flat serrated adenomas and flat tubular adenomas of the colorectal mucosa: differences in the pattern of cell proliferation. Jpn. J. Cancer Res., 86, 756-760 (1995).
16. Rubio, C. S. and Rodensjö, M. p53 Overexpression in flat serrated adenomas and flat tubular adenomas of the colorectal mucosa. J. Cancer Res. Clin. Oncol., 121, 571-576 (1995).
17. Pasricha, P., Bedi, A., O'Connor, K., Rashid, A., Akhtar, A., Zahurac, M., Piantadosi, S., Hamilton, S. and Giardello, M. The effect of Sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis. Gastroenterology, 109, 994-998 (1995).