Enantioselective distribution behavior of (±)-pindolol in a liquid- liquid two-phase system containing optically active diol and boric acid

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 6, 1996, Pages 1250-1251

  Abe, Yoshihiro ^a   Qing, Wang ^a   Shoji, Tomoko ^a   Fukui, Shikie ^a   Suzuki, Mayumi ^a   Kamiyama, Takako ^a   Kobayashi, Michi ^a   Nishizawa, Hideyuki ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

binaphthol; boric acid; enantioseparation; hydrobenzoin; liquid liquid extraction

Indexed keywords

BORIC ACID; PINDOLOL;

AQUEOUS SOLUTION; ARTICLE; BEHAVIOR; CHIRALITY; COMPLEX FORMATION; DRUG DISTRIBUTION; ENANTIOMER; HYDROGEN BOND; LIQUID LIQUID EXTRACTION; MOLECULAR RECOGNITION; NONHUMAN;

EID: 0030037424     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.1250     Document Type: Article

References (8)

1. Abe Y., Shoji T., Kobayashi M., Wang Q., Asai N., Nishizawa H., Chem. Pharm. Bull., 43, 262-265 (1995).
2. a) Prelog V., Stojanac Z., Kovačević K., Helv. Chim. Acta, 65, 377-384 (1982);
3. b) Prelog V., Mutak S., Kovačević K., ibid., 66, 2279-2284 (1983).
4. 3, ppm from TMS); 3.83 (br s, 2H), 3.52-3.6 (m, 4H), 3.41-3.51 (m, 4H), 2.86 (brs, 2H), 1.52-1.64 (m, 4H), 1.2-1.35 (m, 40H), 0.88 (t, J = 8.5 Hz, 6H).
5. Imuta M., Ziffer H., J. Org. Chem., 43, 3319-3323 (1978).
6. Nishio M., Umezawa Y., Hirota M. Takeuchi Y., Tetrahedron, 51, 8665-8701 (1995).
7. Kolb H. C., VanNieuwenhze M. S., Sharpless K. B., Chem. Rev., 94, 2483-2547 (1994), and references cited therein.
8. Hubert A. J., Hargitay B., Dale J., J. Chem. Soc., 1961, 931-936.