Isolated human colon strips as a pharmacological tool

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 18, Issue 5, 1996, Pages 327-333

  Martinez Abad M ^a   Estan L ^b   Martinez Mir I ^c   Rubio, E ^b   Morales Olivas, F J ^b  

^a HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c Hospital General Universitario   (Spain)

Author keywords

Acetylcholine; Gastrointestinal motility; Human colon; Isolated human colon strips; Isoprenaline

Indexed keywords

ACETYLCHOLINE; ISOPRENALINE;

ARTICLE; COLON MOTILITY; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN TISSUE; INTESTINE CONTRACTION;

ACETYLCHOLINE; ADRENERGIC BETA-AGONISTS; CHOLINERGIC AGENTS; COLON; GASTROINTESTINAL MOTILITY; HUMANS; ISOPROTERENOL; ISOTONIC SOLUTIONS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; POTASSIUM CHLORIDE;

EID: 0030037283     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Burlejgh, D.E., Levine, D.F., Moston, R.W. A method for studying the actions of drugs on motility of vasculurly perfused segments of human colon. Arch Int Pharmacodyn 1984, 272: 118-28.
2. Misiewicz, T.J. Colonic motility. Gut 1975, 16: 411-4.
3. Huizinga, J.D., Daniel, E.E. Control of human colonic function. Digest Dis Sci 1986, 31: 865-77.
4. Christensen, J. Motiliiy of the colon. In: Physiology of the Gastrointestinal Tract, 2nd Ed. Johnson, L.R. (Ed.). Raven Press: New York 1987: 595-629.
5. Sarna, S.K. Physiology and pathophysiology of colonic motor activity. Part I. Digest Dis Sci 1991, 36: 827-62.
6. Bassotti, G., Crowell, M.D., Whitehead, W.E. Contractile activity of the human colon: Lessons from 24 hour studies. Gut 1993, 34: 129-33.
7. Wyman, J.V., Heaton, K.W., Wicks, A.C.B. Variability of colonic function in healthy subjects. Gut 1978, 19: 146-50.
8. Kerlin, P., Zinsmeister, A., Phillips, S. Motor responses to food of the ileum, proximal colon and distal colon of healthy humans. Gastroenterology 1983, 84: 762-70.
9. Frexinos, J , Bueno, L , Fioramonti, J. Diurnal changes in myoelectric spiking activity of the human colon. Gastroenterology 1985, 88: 1104-10.
10. Bassotti, G., Bucaneve, G., Pelli, M.A., Morelli, A. Contractile frequency patterns of the human colon. J Gastrointest Motil 1990, 2: 73-8
11. Christensen. J., Stiles, M.J., Rick, G.A., Sutherland, J. Comparative anatomy of the myenteric plexus of the distal colon in eight mammals Gastroenterology 1984, 86: 706-13
12. Christensen, J., Caprilli, R., Lund, G.F Electrical slow waves in circular muscle of the cat colon. Amer J Physiol 1969, 217: 771-6.
13. El-Sharkawy, T.Y. Electrical activities of the muscle layers of the canine colon. J Physiol 1983, 342: 67-83.
14. Huizinga, J.D., Daniel, E,E Motor functions of the colon. In: The Large Intestine: Physiology, Pathophysiology, and Disease. Philhps, S.F., Pemberton, J.H., Shorter, R.G. (Eds.). Raven Press: New York 1991, 93-114.
15. Crowell, M.D., Musial, F., French, A.W Eating lowers defecation threshold in pigs cholinergic pathways. Physiol Behav 1993, 53: 1029-32.
16. Belisle, S., Gagnon, D.J. Stimulating action of catecholamines on isolated preparations of the rat colon and human and rabbit taenia coli. Brit J Pharmacol 1971, 41: 361-6.
17. Gagnon, D.J., Devroede, G., Belisle, S. Excitatory effects of adrenaline upon isolated preparations of human colon. Gut 1972, 13: 654-7.
18. Dinoso, VP, Murthy, S.N.S., Goldstein, J., Rosner, B. Basal motor activity of the distal colon: A reappraisal. Gastroenterology 1983, 85: 637-42.
19. Furness, J.B., Costa, M. The adrenergic innervation of the gastrointestinal tract. Rev Physiol Biochem Exp Pharmacol 1974, 69: 1-51.
20. Ek, B., Lundgren, B. Characterization of the β-adrenergic inhibition of motility in cat colon strips. Eur J Pharmacol 1982, 77: 25-31.
21. Lyrenas, E., Abrahamsson, H., Dotevall, G. Rectosigmoid motility response to beta-adrenoceptor stimulation in patients with the irritable bowel syndrome. Scand J Gastroenterol 1985, 20: 1163-8.
22. Burleigh, D E. Evidence for more than one type of 5-hydroxytryptamine receptor in the human colon. J Pharm Pharmacol 1977, 29: 538-41.
23. Boeckxstaens. G E., Pelckmans, P.A., Herman, A.G., Van Maercke, Y.M. Involvement of nitric oxide in the inhibitory innervation of the human isolated colon. Gastroenterology 1993, 104: 690-7.
24. Lanfranchi, G.A., Marzio, L., Cortini, C., Moreno-Osset, E. Motor effect of dopamine on human sigmoid colon. Evidence for specific receptors. Amer J Digest Dis 1978, 23: 257-63.
25. Lechin, F , Van Der Digs, B. Effects of dopaminergic blocking agents on distal colon motility. J Clin Pharmacol 1979, 19: 617-25.
26. Fishlock, D.J., Parks, A.G. The action of nicotine on the circular muscle of the human ileum and colon in vitro. Brit J Pharmacol 1966, 26: 79-86.
27. Rennie, J.A., Chnstofides, N.D., Mitchenere, P. et al. Neural and humoral factors in postoperative ileus. Brit J Surg 1980, 67: 694-8.
28. Kerr, P.M., Hillier, K., Wallis, R.W., Garland, C.J. Characterization of muscarinic receptors mediating contractions of circular and longitudinal muscle of human isolated colon. Brit J Pharmacol 1995, 115: 1518-24
29. Martínez-Mir, I., Estañ, L., Rubio, E., Morales-Olivas. F.J. Antihistaminic and anticholinergic activities of mequitazine in comparison with clemizole. J Pharm Pharmacol 1988, 40: 655-6.
30. 2-histamine receptor antagonists in the isolated uterus of the rat. J Pharm Pharmacol 1982, 34: 740-1.
31. Aguilar, M.J., Morales-Olivas, F.J., Rubio, E. Pharmacological investigation into the effects of histamine and histamine analogues on guinea-pig and rat colon in vitro. Brit J Pharmacol 1986, 88: 501-6.
32. Martínez-Mir, I., Estañ, L.. Morales-Olives, F.J., Rubio, E. Studies of the spontaneous motility and the effect of histamine on isolated myometrial strips of the nonpregnant human uterus: The influence of various uterine abnormalities. Amer J Obstet Gynecol 1990, 163: 189-95.
33. Rubio, E., Estañ, L.A., Morales-Olivas. F.J., Martínez-Mir. I. Influence of hormonal treatment on the response of the rat isolated uterus to histamine and histamine receptor agonists. Eur J Pharmacol 1992, 212: 31-6.
34. Bennett, A., Stamford, I.F., Sanger, G.J., Bloom, S.R. The effects of various peptides on human isolated gut muscle. J Pharm Pharmacol 1992, 44: 960-7.
35. Steadman, C.J., Phillips, S.F., Camilleri, M., Talley, N.J., Haddad, A., Hanson, R. Control of muscle tone in the human colon. Gut 1992, 33: 541-6.
36. Estan̄, L., Martíez-Mir, I., Rubio, E., Morales-Olivas, F.J. No evidence for dopamine-induced relaxation in isolated human mesenteric arterial strips from elderly patients. Gen Pharmacol 1995, 26: 1687-94.
37. Martínez-Mir, I., Estañ, L., Morales-Olivas, F.J., Rubio, E. Effect of histamine and histamine analogues on human isolated myometrial strips. Brit J Pharmacol 1992, 107: 528-31.
38. Bassotti, G., Imbimbo, B.P., Betti, C., Erbella, G.S., Pelli. M.A., Morelli, A. Edrophonium chloride for testing colonic contractile activity in man. Acta Physiol Scand 1991, 141: 289-93.
39. Kilbinger, H. The myenteric plexus-longitudinal muscle preparation. In: Progress in Cholinergic Biology, Vol. 1: Model Cholinergic Synapses. Hanin, J., Goldberg, C.I. (Eds.) Raven Press: New York 1982, 132-67.
40. Kosterlitz, H.W., Lees, G.M. Pharmacological analysis of intrinsic intestinal reflexes. Pharmacol Rev 1964, 16: 301-39.
41. Kosterlitz, H.W. Effects of choline esters on smooth muscle and secretions. In: Physiological Pharmacology, Vol. III. Root, W.S., Hofmann, F.G. (Eds.). Academic Press: New York 1967, 97-161.
42. McKirdy, H.C. Functional relationship of longitudinal and circular layers of the muscularis externa of the rabbit large intestine. J Physiol 1972, 22: 839-53.
43. Kuwahara, A., Cooke, H.J., Carey, H.V., Mekhjian, H., Ellison, E.C., McGregor, B. Effects of enteric neural stimulation on chloride transport in human left colon in vitro Digest Dis Sci 1989, 34: 206-13.