Synthesis of 3″-desmethoxyazithromycin: Regioselectivity and stereoselectivity of SmI2-mediated α-deoxygenation reaction

Journal of Organic Chemistry

Volumn 61, Issue 15, 1996, Pages 5149-5152

  Yang, Bingwei V ^a   Massa, Mark A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3'' DEMETHOXYAZITHROMYCIN; AZITHROMYCIN; AZITHROMYCIN DERIVATIVE; MACROLIDE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; REACTION ANALYSIS;

EID: 0030037071     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo960372j     Document Type: Article

References (13)

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12. The ratio of product mixture was determined from the integral of the proton NMR spectra for macrolides and by GC-MS for cladinose derivatives.
13. 4-Cl), 15 and 17 isomerized to their corresponding epimers, but in addition, generated a third, uncharacterized, compound.