Immunodetection of histone epitopes correlates with early stages of apoptosis in activated human peripheral T lymphocytes

American Journal of Pathology

Volumn 149, Issue 2, 1996, Pages 653-663

  Zunino, Susan J ^a   Singh, Manoj K ^a   Bass, Julia ^a   Picker, Louis J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA NUCLEOTIDYLEXOTRANSFERASE; EPITOPE; HISTONE H2B; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELLS, CULTURED; DNA DAMAGE; DNA NUCLEOTIDYLEXOTRANSFERASE; EPITOPES; FLOW CYTOMETRY; HISTONES; HUMANS; LYMPHOCYTE ACTIVATION; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; REFERENCE VALUES; T-LYMPHOCYTES;

EID: 0030037058     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. MacDonald HR, Less RK: Programmed cell death of autoreactive thymocytes. Nature 1990, 343:225-228
2. Akbar AN, Salmon M, Savill J, Janossy G: A possible role for bcl-2 in regulating T cell memory: a 'balancing act' between cell death and survival. Immunol Today 1993, 14:526-532
3. Crispe IN: Fatal interactions: Fas-induced apoptosis of mature T cells. Immunity 1994, 1:347-349
4. Smith CA, Williams GT, Kingston R, Jenkinson EJ, Owen JJT: Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells. Nature 1989, 337:181-185
5. Odaka C, Kizaki H, Tadakuma T: T cell receptor-mediated DNA fragmentation and cell death in T cell hybridomas. J Immunol 1990, 144:2096-2105
6. D'Adamio L, Awad KM, Reinherz EL: Thymic and peripheral apoptosis of antigen-specific T cells might co-operate in establishing self-tolerance. Eur J Immunol 1993, 23:747
7. Janssen O, Wesselborg S, Heckl-Ostreicher B, Bender A, Schondlemaier S, Pechhold K, Moldenhauer G, Kabelitz D: T cell receptor/CDS-signalling induces death by apoptosis in human T-cell receptor γδ-positive T cells. J Immunol 1991, 146:35
8. Webb S, Morris C, Sprent J: Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 1990, 63:1249-1262
9. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 1991, 349:245-249
10. Arends MJ, Morris RG, Wyllie AH: Apoptosis: the role of endonuclease. Am J Pathol 1990, 136:593-608
11. Wyllie AH, Kerr JFR, Currie AR: Cell death: the significance of apoptosis. Int Rev Cytol 1980, 68:251-264
12. Gorczyca W, Gong J, Darzynkiewicz Z: Detection of DNA strand breaks in individual apoptotic cell by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 1993, 1951, 53:1945
13. Laurent-Crawford AG, Krust B, Muller S, Riviere Y, Rey-Cuille MA, Bechet J-M, Montagnier L, Hovanessian AG: The cytopathic effect of HIV is associated with apoptosis. Virology 1991, 185:829-839
14. Jung T, Schauer U, Heusser C, Neumann C, Rieger C: Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993, 159:197-207
15. Picker LJ, Singh MK, Zdraveski Z, Treer JR, Waldrop SL, Bergstresser PR, Maino VC: Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 1995, 86:1408-1419
16. Schmid I, Uittenbogaart CH, Giorgi JV: Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry 1994, 15:12-20
17. Harlow E, Lane D: Antibodies: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1988, pp 524-525
18. Rault-Leonardon M, Atkinson MAL, Slaughter CA, Moomaw CR, Srere PA: Azotobacter vinelandii citrate synthase. Biochemistry 1995, 34:257-263
19. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C: A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991, 139:271-279
20. Van Holde KE: Chromatin. New York, Springer-Verlag, 1989
21. Boulikas T, Wiseman JM, Garrard WT: Points of contact between histone H1 and the histone octamer. Proc Natl Acad Sci USA 1980, 77:127-131
22. Boulikas T: Poly(ADP-ribosyl)ation, DNA strand breaks, chromatin, and cancer. Toxicol Lett 1993, 67:129-150
23. Kerr JFR, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972, 26:239-257
24. Wyllie AH, Morris RG, Smith AL, Dunlop D: Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macronuclear synthesis. J Pathol 1984, 142:67-77
25. Brown DG, Sun X-M, Cohen GM: Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J Biol Chem 1993, 268:3037-3039
26. 2+-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis. J Biol Chem 1994, 269:14857-14860
27. Huletsky A, de Murcia G, Muller S, Hengartner M, Menard L, Lamarre D, Poirier GG: The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin: a role of poly(ADP-ribosyl)ation on core nucleosome structure. J Biol Chem 1989, 264:8878-8886
28. Boulikas T: DNA strand breaks alter histone ADP-ribosylation. Proc Natl Acad Sci 1989, 86:3499-3503
29. Mathis G, Althaus FR: Periodic changes of chromatin organization associated with rearrangement of repair patches accompany DNA excision repair of mammalian cells. J Biol Chem 1986, 261:5758-5765
30. Realini CA, Althaus FR: Histone shuttling by poly(ADP-ribosyl)ation. J Biol Chem 1992, 267:18858-18865
31. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG: Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 1993, 53: 3976-3985
32. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC: Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties ICE-like. Nature 1994, 371:346-347
33. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salveson GS, Dixit VM: Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995, 81:801-809
34. Kaufmann SH: Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res 1989, 52:5870-5878
35. Casciola-Rosen LA, Miller DK, Anhalt GJ, Rosen A: Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J Biol Chem 1994, 269:30757-30760
36. Lin R, Cook RG, Allis CD: Proteolytic removal of core histone amino termini and dephosphorylation of histone H1 correlate with the formation of condensed chromatin and transcriptional silencing during Tetrahymena macronuclear development. Genes Dev 1991, 5:1601-1610