Alcohol and drug interactions: Mechanisms and practical outcomes;Les interactions alcool-medicaments: Mecanismes et consequences pratiques

Journal de Pharmacie Clinique

Volumn 15, Issue 2, 1996, Pages 91-98

  Ernouf, D ^a,b   Boussa, N ^b  

^a UFR de Pharmacie   (France)

^b CHU BRETONNEAU   (France)

Author keywords

alcohol and drug interaction; pharmacodynamics; pharmacokinetics

Indexed keywords

CYTOCHROME P450; SEDATIVE AGENT; UNINDEXED DRUG;

ALCOHOL CONSUMPTION; BIOTRANSFORMATION; DRUG ABSORPTION; DRUG ALCOHOL INTERACTION; DRUG METABOLISM; DRUG USE; HUMAN; LIVER FUNCTION; LIVER INJURY; PHARMACODYNAMICS; PHARMACOKINETICS; REVIEW;

EID: 0030036757     PISSN: 02911981     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (58)

1. Bjarnason I, Ward K, Peters TJ. The leaky gut of alcoholism : possible route of entry for toxic compounds. Lancet 1984 ; i ; 8370 : 179-82.
2. Bond AJ, Silveira JC, Lader M The effects of alprazolam alone and combined with alcohol on central integrative activity. Eur J Clin Pharmacol 1992 ; 42 : 495-8.
3. Brockmöller J, Roots I. Assessment of liver metabolic function Clinical implications. Clin Pharmacokinet 1994 ; 27 : 216-48.
4. 2-receptors antagonists on gastric alcohol deshydrogenase activity. Dig Dis Sci 1991 ; 36 : 1673-9
5. Caballeria J, Baraona E, Rodamilans M, Lieber CS. Effects of cimetidine on gastric alcohol deshydrogenase activity and blood ethanol levels. Gastroenterology 1989 ; 96 : 388-92.
6. e ed. Paris: Expansion Scientifique Française, 1988 : 249-62.
7. Ciraulo DA, Barnhill J. Pharmacokinetic mechanisms of ethanol-psychotropic drug interaction. Natl Inst Drug Abuse Res Monogr Ser 1986 ; 68 : 73-88.
8. Couzigou P, Fleury B, Bourjac M, Betbeder AM, Vinçon G, Richard-Molard B, Albin H, Amouretti M, Béraud C. Pharmacocinétique de l'alcool après perfusion intraveineuse de trois heures avec et sans cimétidine chez dix sujets sains non alcooliques. Castroenterol Clin Biol 1984 ; 8 : 103-8.
9. Edwards DJ, Babiak LM, Beckman HB. The effect of a single oral dose or ethanol on hepatic blood flow in man. Eur J Clin Pharmacol 1987 ; 32 : 481-4.
10. Ernouf D. Interactions alcool-médicaments. Thérapie 1995 ; 50 : 199-202.
11. Ernouf D., Aubin B, Narcisse G, Daoust M. Alcool et benzodiazépines: que de ressemblances. Alcoologie 1995 ; 17 : 136-43
12. Ernouf D, Furet Y, Narcisse G. Interactions tabac-médicarnents: mécanismes et conséquences thérapeutiques. Lyon Pharm 1988 ; 39 : 121-5.
13. Felerman DE, Winston GW, Cederbaum AI. Ethanol oxidation by hydroxyradicals: role of iron chelates, superoxide, and hydrogen peroxide. Alcohol Clin Exp Res 1985 ; 9 : 95-102.
14. Georges CF. Drug kinetics and hepatic blood flow. Clin Pharmacokinet 1979 ; 4 : 433-48.
15. Girre C, Hirschhorn M, Bertaux L, Palombo S, Dellatolas. F, Ngo R, Moreno M, Fournier PE. Enhancement of propoxyphene bioavailability by ethanol. Eur J Clin Pharmacol 1991 ; 41 : 147-52.
16. Girre C, Hispard E, Palombo S, N'Guyen C, Dally S. Increased metabolism of acetaminophen in chronically alcoholic patients. Alcohol Clin Exp Res 1993 ; 17 : 170-3.
17. Guengerich FP, Beaune PH, Umbenhauer DR, Churchill PF, Bork RW, Dannan GA, Knodell RG, Lloyd RS, Martin MV. Cytochrome P450 enzymes involved in genetic polymorphism of drug oxidation in man. Biochem Soc Trans 1987 ; 15 : 576-8.
18. Gupta AM, Baraona E, Lieber CS Significant increase of blood alcohol by cimetidine after repetitive drinking of alcohol doses. Alcohol Clin Exp Res 1995 ; 19 : 1083-7.
19. 2-receptor antagonists, and its effects on the bioavailability of ethanol. Alcohol Clin Exp Res 1990 ; 14 : 946-50.
20. 20, 7-1987.
21. Holford NHG. Clinical pharmacokinetics of ethanol. Clin Pharmacokinet 1987 ; 13 : 273-92.
22. Ideo G, de Franchis R, del Ninno E. Ethanol increases liver uridine-diphosphate-glucuronyltransferase. Experientia 1971 ; 27 : 24-9.
23. Julkunen RJK, Dipadova C, Lieber CS. First pass metabolism of ethanol - a gastrointestinal barrier against the systemic toxicity of ethanol. Life Sci 1985 ; 37 : 567-73.
24. Kopanoff DE, Snider DE Jr, Caras GJ. Isoniazid-related hepatitis : a US. Public Health Service cooperative surveillance study. Am Rev Respir Dis 1978 ; 117 : 991-1001.
25. Kunsman GW, Manno JE, Przekop MA, Manno BR, Kunsman CM. The effects of temazepam and ethanol on human psychomotor performance. Eur J Clin Pharmacol 1992 ; 43 : 603-11.
26. Labaune JP. Influence de la consommation d'alcool et de tabac sur la pharmacocinétique des médicaments. Les Actualités Pharmaceutiques 1987 ; 240 : 69-75.
27. Laisi U, Linnoila M, Seppala T, Himberg JJ, Mattila MJ. Pharmacokinetic and pharmacodynamic interactions of diazepam with different alcoholic beverages. Eur J Clin Pharmacol 1979 ; 16 : 263-9.
28. Lane EA, Guthrie S, Linnoila M. Effects of ethanol on drug and metabolite pharmacokinetics. Clin Pharmacokinet 1985 ; 10 : 228-47.
29. Lauterburg BH, Velez ME. Glutathione deficiency in alcoholics : risk factor for paracetamol hepatotoxicity. Gut 1988 ; 29 : 1153-7.
30. Lieber CS. Metabolism of ethanol and associated interactions with other drugs, carcinogens, and vitamins. NY State J Med 1986 ; 86 : 297-302.
31. Lieber CS Microsomal ethanol-oxidizing system. Enzyme 1987 ; 37 : 45-56.
32. Lieber CS. Interaction of alcohol with other drugs and nutrients. Implication for the therapy of alcoholic liver disease. Drugs 1990 ; 40 (suppl 3) : 71-9.
33. Lieber CS. Medical disorders of alcoholism. N Engl J Med 1995 ; 333 : 1058-65.
34. Lim Jr RT, Gentry RT, Ito D, Yokogama H, Baraona E, Lieber CS. First pass metabolism of ethanol is predominantly gastric. Alcohol Clin Exp Res 1993 ; 17 : 1337-44.
35. Linnoila ML. Benzodiazepines and alcohol. J Phychiatr Res 1990 ; 24 (suppl 2) : 121-7.
36. Lydiard RB. Use of benzodiazepine by alcoholics Am J Psychiatry 1990 ; 147 : 128-9.
37. Makin A, Williams R. The current management of paracetamol overdosage BJCP 1994 ; 48 : 144-8.
38. Mattila MJ. Alcohol and drug interactions. Ann Med 1990 ; 22 : 363-9.
39. Mirmizan-Yardy SAA, Haber PS, Korsten MA, Mak KM, Gentry RT, Batra SC, Lieber CS. Metabolism of ethanol in rat gastric cells and its inhibition by cimetidine. Gastroenterology 1995 ; 108 : 737-42.
40. Morgan DD, Robinson JD, Mendenhall CL. Clinical pharmacokinetics of chlordiazepoxide in patients with alcoholic hepatitis. Eur J Clin Pharmacol 1981 ; 19 : 279-85.
41. Okey AB. Enzyme induction in the cytochrome P450 system. Pharmacol Ther 1989 ; 45 : 241-98.
42. Ollat H, Parvez H, Parvez S. Alcohol and central neurotransmission. Neurochem Int 1988 ; 13 : 275-300.
43. Paille F, Pissochet P, Pirollet P. Alcoolisation aiguë et médicaments. Rev Prat 1993 ; 43 : 2075-80.
44. Parker G, Roberts CJC. Plasma concentrations and central nervous system effects of a new hypnotic agent zopiclone in patients with chronic liver disease. Br J Clin Pharmacol 1983 ; 16 : 259-65.
45. Pelkonen O, Sotaniemi E. Drug metabolism in alcoholics. Pharmacol Ther 1982 ; 16 : 261-8.
46. Roberts MS, Rumble RH, Wanwimolruk S, Thomas D, Brooks PM. Pharmacokinetics of aspirine and salicylate in elderly subjects and in patients with alcoholic liver disease. Eur J Clin Pharmacol 1983 ; 25 : 253-61.
47. Rothschild MA, Oratz M, Schereiber SS. Effects of nutrition and alcohol on albumin synthesis. Alcohol Clin Exp Res 1983 ; 7: 28-30.
48. Salaspuro M. Inhibitors of alcohol metabolism. Acta Med Scand 1985, 703 (suppl): 219-24.
49. Sato C, Lieber CS. Mechanism of the preventive effect of ethanol and acetaminophen-induced hepatotoxicity. J Pharmacol Exp Ther 1981 ; 218 : 211-5.
50. Soulnier JL, Talbert M. Médicaments, heure, tabac et alimentation. Seconde ed. Paris : Frison Roche - Sidem, 1988.
51. Sherlock S. Nutrition and the alcoholic. Lancet 1984 ; 1 : 436-8.
52. Slattery JT, Kalhorn TF, Thummel KE. Mechanisms by which acetaminophen administration diminishes ethanol clearance. Drug Metab Dispos 1991 ; 19 : 558-60.
53. Somogyi A, Albrecht M, Klierns G, Schäfer K, Eichelbaum M. Pharmacokinetics, bioavailability and ECG response of verapamil in patients with liver cirrhosis. Br J Clin Pharmacol 1981 ; 12 : 51-60.
54. Stockley IH. Drugs foods and environmental chemical agents which can initiate antabuse like reactions with alcohol. Pharm Intern 1983 ; 1 : 12-6.
55. Stockley IH. Alcohol interactions. In : Stockley IH ed. Drug interactions. A source book of drug interactions, their mechanisms, clinical importance and management, Second ed. Oxford: Blackwell Scientific Publication, 1991 : 14-38.
56. Sun GY, Sun AY. Ethanol and membrane lipids. Alcohol Clin Exp Res 1985 ; 9 : 164-80.
57. Tsutsumi M, Takada A, Wang JS. Genetic polymorphisms of cytochrome P450 II E1 related to the development of alcoholic liver disease. Gastroenterology 1994 ; 107 : 1430-35.
58. Wagner JG, Weidler DJ, Lin YJ. New method for detecting and quantitating pharmacokinetics drug-drug interactions applied to ethanol-propranolol. Res Commun Chem Pathol Pharmacol 1976 ; 13 : 9-18.