Evaluating human variability in chemical risk assessment: Hazard identification and dose-response assessment for noncancer oral toxicity of trichloroethylene

Toxicology

Volumn 111, Issue 1-3, 1996, Pages 271-287

  Barton, H A ^a   Flemming, C D ^a   Lipscomb, J C ^a  

^a WRIGHT PATTERSON AIR FORCE BASE   (United States)

Author keywords

Monte Carlo simulation; Reproductive and developmental toxicity; Risk assessment; Sensitive populations; Trichloroethylene

Indexed keywords

TRICHLOROETHYLENE;

CONFERENCE PAPER; DOSE RESPONSE; HUMAN; MODEL; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; SYSTEM ANALYSIS; TOXICOKINETICS; XENOBIOTIC METABOLISM;

ANIMALIA; RODENTIA;

EID: 0030036369     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(96)03382-3     Document Type: Conference Paper

References (84)

1. D.P. Agarwal H.W. Goedde Pharmacogenetics of alcohol metabolism and alcoholism Pharmacogenetics 2 1992 48 62
2. B.C. Allen J.W. Fisher Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans Risk Anal. 13 1993 71 86
3. B.C. Allen R.J. Kavlock C.A. Kimmel E.M. Faustman Dose-response assessment for developmental toxicity. II. Comparison of generic benchmark dose estimates with no observed adverse effect levels Fundam. Appl. Toxicol. 23 1994 487 495
4. M.O. Amdur Health effects of air pollutants: sulfuric acid, the old and the new Environ. Health Perspect. 81 1989 109 113
5. ATSDR (Agency for Toxic Substance and Disease Registry) Toxicological profile for trichloroethylene: update TP-92/19 1993 ATSDR Atlanta
6. R.P. Beliles D.J. Brusick F.J. Mecler Teratogenic-mutagenic risk of workplace contaminants: trichloroethylene, perchloroethylene, and carbon disulfide Contract report, contract no. 210-77-0047 1980 US Dept. of HEW, NIOSH Cincinnati, OH TOSCA submission no. OTS0538069
7. K.W. Bock D. Schrenk A. Forster E.-U. Griese K. Morike D. Brockmeier M. Eichelbaum The influence of environmental and genetic factors on CYP2D6, CYP1A2, and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes Pharmacogenetics 4 1994 209 218
8. F.Y. Bois G. Krowech L. Zeise Modeling human interindividual variability in metabolism and risk: the example of 4-aminobiphenyl Risk Anal. 15 1995 205 214
9. J.A. Buben E.J. O'Flaherty Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-response study Toxicol. Appl. Pharmacol. 78 1985 105 122
10. H.J. Clewell T. Lee R.L. Carpenter Sensitivity of physiologically based pharmacokinetic models to variation in model parameters: methylene chloride Risk Anal. 14 1994 521 531
11. H.J. Clewell P.R. Gentry J.M. Gearhart B.C. Allen M.E. Andersen Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene 1995
12. J.R. Cooper H. Friedman The enzymatic oxidation of chloral hydrate to trichloroacetic acid Biochem. Pharmacol. 1 1958 76 82
13. N.C. Cosby W.R. Dukelow Toxicology of maternally ingested trichloroethylene (TCE) on embryonal and fetal development in mice and of TCE metabolites on in vitro fertilization Fundam. Appl. Toxicol. 19 1992 268 274
14. K.E. Crow T.M. Kitson A.K.H. MacGibbon R.D. Batt Intracellular localisation and properties of aldehyde dehydrogenases from sheep liver Biochim. Biophys. Acta 350 1974 121 128
15. 4 hepatotoxicity Toxicology 1996 (in press)
16. I.W.F. Davidson R.P. Beliles Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics Drug Metab. Rev. 23 1991 493 499
17. B.V. Dawson P.D. Johnson S.J. Goldberg J.B. Ulreich Cardiac teratogenesis of trichloroethylene and dichloroethylene in mammalian model J. Am. Coll. Cardiol. 16 1990 1304 1309
18. B.V. Dawson P.D. Johnson S.J. Goldberg J.B. Ulreich Cardiac teratogenesis of halogenated hydrocarbon-contaminated drinking water J. Am. Coll. Cardiol. 21 1993 1466 1472
19. P.A. Dockham M.-O. Lee N.E. Sladek Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde Biochem. Pharmacol. 43 1992 2453 2469
20. M.A. Dorfmueller S.P. Henne R.G. York R.L. Bornschein J.M. Manson Evaluation of teratogenicity and behavioral toxicity with inhalation exposure of maternal rats to trichloroethylene Toxicology 14 1979 153 166
21. M.L. Dourson Methods for establishing oral reference doses W. Mertz C.O. Abernathy S.S. Olin Risk Assessment of Essential Elements 1994 ILSI Press Washington, DC 51 61
22. K. Edman W. Maret Alcohol dehydrogenase genses: restriction fragment length polymorphisms for ADH4 (π-ADH) and ADH5 (χ-ADH) and construction of haplotypes among different ADH classes Hum. Genet. 90 1992 395 401
23. C.R. Elcombe M.S. Rose I.S. Pratt Biochemical, histological, and ultrastructural changes in rat and mouse liver following the administration of trichloroethylene: possible relevance to species differences in hepatocarcinogenicity Toxicol. Appl. Pharmacol. 79 1985 365 376
24. P.J. Friedman J.R. Cooper The role of alcohol dehydrogenase in the metabolism of chloral hydrate J. Pharmacol. Exp. Ther. 129 1960 373 376
25. S.J. Goldberg M.D. Lebowitz E.J. Graver S. Hicks An association of human congenital cardiac malformations and drinking water contaminants J. Am. Coll. Cardiol. 16 1990 155 164
26. D.K.J Gorecki K.W. Hindmarsh C.A. Hall D.J. Mayers Determination of chloral hydrate metabolism in adult and neonate biological fluids after single-dose administration J. Chromatogr. 528 1990 333 341
27. E. Hallier T. Langhof D. Dannapel M. Leutbecher K. Schroder H.W. Goergens A. Muller H.M. Bolt Polymorphism of glutathione conjugation of methyl bromide, ethylene oxide and dichloromethane in human blood: influence on the induction of sister chromatid exchange (SCE) in lymphocytes Arch. Toxicol. 67 1993 173 178
28. A. Hara H. Yamamoto Y. Deyashiki T. Nakayama H. Oritani H. Sawada Aldehyde dismutation catalyzed by pulmonary carbonyl reductase: kinetic studies of chloral hydrate metabolism to trichloroacetic acid and trichloroethanol Biochim. Biophys. Acta 1075 1991 61 67
29. B.D. Hardin G.P. Bond M.R. Sikow F.D. Andrew R.P. Beliles R.W. Niemeier Testing of selected work-place chemicals for teratogenic potential Scand. J. Work Environ. Health 7 1981 66 75
30. D. Hattis K. Silver Human interindividual variability: a major source of uncertainty in assessing risks for noncancer health effects Risk Anal. 14 1994 421 431
31. T.E.J. Healy T.R. Poole A. Hopper Rat fetal development and maternal exposure to trichloroethylene 100 ppm Br. J. Anaesth. 54 1982 337 340
32. R.C. Hertzberg M. Miller A statistical model for species extrapolation using categorical response data Toxicol. Ind. Health 1 1985 43 63
33. IIAM (International Institute for the Advancement of Medicine) Characterization of specific CYP450 isoenzyme activities in human liver microsomal samples (effective May 3, 1995) 1995 Exton, PA
34. M. Ikeda Y. Miyake M. Ogata S. Ohmori Metabolism of trichloroethylene Biochem. Pharmacol. 29 1980 2983 2992
35. M. Ikeda M. Ezaki S. Kokeguchi S. Ohmori Studies on NADPH-dependent chloral hydrate reducing enzymes in rat liver cytosol Biochem. Pharmacol. 30 1981 1931 1939
36. L.G. Isaacson D.H. Taylor Maternal exposure to 1,1,2-trichloroethylene affects myelin in the hippocampal formation of the developing rat Brain Res. 488 1989 403 407
37. L.G. Isaacson S.A. Spohler D.H. Taylor Trichloroethylene affects learning and decreases myelin in the rat hippocampus Neurotoxicol. Teratol. 12 1990 375 381
38. D.R. Jaffe A.J. Gandolfi R.B. Nagle Chronic toxicity of S -(trans-1,2-dichlorovinyl)-L-cysteine in mice J. Appl. Toxicol. 4 1984 315 319
39. L.S. Kaminsky J.M. Fraser M. Seaman D. Dunbar Rat liver metabolism and toxicity of 2,2,2-trifluoroethanol Biochem. Pharmacol. 44 1992 1829 1837
40. P. Kjellstrand M. Kanje L. Mansson M. Bjerkemo I. Mortensen J. Lanke B. Holmquist Trichloroethylene: effects on body and organ weights in mice, rats, and gerbils Toxicology 21 1981 105 115
41. P.C. Land E.L. Owen H.W. Linde Morphologic changes in mouse spermatozoa after exposure to inhalational anesthetics during early spermatogenesis Anesthesiology 54 1981 53 56
42. J.C. Lipscomb D.A. Mahle W.T. Brashear H.A. Barton Dichloroacetic acid: metabolism in cytosol Drug Metab. Dispos. 23 1995 1202 1205
43. J.M. Manson M. Murphy N. Richardale M.K. Smith Effects of oral exposure to trichloroethylene on female reproductive function Toxicology 32 1984 229 242
44. E.K. Marshall Jr. A.H. Owens Jr. Absorption, excretion and metabolic fate of chloral hydrate and trichloroethanol Bull. Johns Hopkins Hosp. 95 1954 1 18
45. D.J. Mayers K.W. Hindmarsh K. Sankaran D.K.J. Gorecki G.F. Kasian Chloral hydrate disposition following single-dose administration to critically ill neonates and children Dev. Pharmacol. Ther. 16 1991 71 77
46. B.A. Merrick M. Robinson L.W. Condie Differing hepatotoxicity and lethality after subacute trichloroethylene exposure in aqueous or corn oil gavage vehicles in B6C3F1 mice J. Appl. Toxicol. 9 1989 15 21
47. R.E. Miller F.P. Guengerich Oxidation of trichloroethylene by liver microsomal P450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide Biochemistry 12 1982 1090 1097
48. T. Nakajima T. Okino S. Okuyama T. Kaneko I. Yonekura A. Sato Ethanol-induced enhancement of trichloroethylene metabolism and hepatotoxicity: difference from the effect of phenobarbital Toxicol. Appl. Pharmacol. 94 1988 227 237
49. T. Nakajima R.S. Wang E. Elovaara S.S. Park H.V. Gelboin H. Vainio A comparative study on the contribution of cytochrome P-450 isozymes to the metabolism of benzene, toluene and trichloroethylene in rat liver Biochem. Pharmacol. 43 1992 251 257
50. M.G. Narotsky E.A. Weller V.M. Chinchilli R.J. Kavlock Nonadditive developmental toxicity in mixtures of trichloroethylene, di-(2-ethylhexyl)phthalate and heptachlor in a 5 × 5 × 5 design Fundam. Appl. Toxicol. 27 1995 203 216
51. NCI (National Cancer Institute) Carcinogenesis bioassay of trichloroethylene PB-264122 1976 NCI Washington, DC
52. NTP (National Toxicology Program) Trichloroethylene: reproduction and fertility assessment in CD-1 mice when administered in the feed. Final report PB86-173150 1985 NTP, National Institute of Environmental Health Science Triangle Park, NC
53. NTP (National Toxicology Program) Trichloroethylene: reproduction and fertility assessment in F344 rats when administered in feed. Final report PB86-190782 1986 NTP, National Institutes of Environmental Health Sciences Research Triangle Park, NC
54. NTP (National Toxicology Program) Toxicology and carcinogenesis studies of trichloroethylene (Cas No. 79-01-6) in four strains of rats (ACI, August, Marshall, Osborne-Mendel) (gavage studies) PB88-218896 1988 NTP, National Institute of Environmental Health Sciences Research Triangle Park, NC
55. K. Ogino T. Hobara H. Kobayashi S. Iwamoto Comparative study of the tissue distribution of NADH and NADPH-dependent chloral hydrate reducing enzymes in the rat Bull. Environ. Contam. Toxicol. 44 1990 377 379
56. T. Okino T. Nakajima M. Nakano Morphological and biochemical analyses of trichloroethylene hepatotoxicity: differences in ethanol- and phenobarbitalpretreated rats Toxicol. Appl. Pharmacol. 108 1991 379 389
57. A.H. Owens Jr. E.K. Marshall Jr. Further studies on the metabolic fate of chloral hydrate and trichloroethanol Bull. Johns Hopkins Hosp. 97 1955 320 326
58. S. Pemble R. Schroeder S.R. Spencer D.J. Meyer E. Hallier H.M. Bolt B. Ketterer J.B. Taylor Human glutathione transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism Biochem. J. 300 1994 271 276
59. H. Peter S. Deutschmann C. Reichel E. Hallier Metabolism of methyl chloride by human erythrocytes Arch. Toxicol. 63 1989 351 355
60. R. Peter R. Bocker P.H. Beaune M. Iwasaki F.P. Guengerich C.S. Yang Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450 IIE1 Chem. Res. Toxicol. 3 1990 566 573
61. J.K. Ritter J.M. Crawford I.S. Owens Cloning of two human liver bilirubin UDP-glucuronosyl-transferase cDNAs with expression in COS-1 cells J. Biol. Chem. 266 1991 1043 1047
62. Sas Institute Inc., Fourth Ed. SAS/STAT User's Guide 1990 SAS Institute, Inc., Cary, NC Version 6
63. A. Sato T. Nakajima Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake, and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methyl cholanthrene: a comparative study Xenobiotica 15 1985 67 75
64. K.R. Schroeder F.A. Wiebel E. Hallier H.M. Bolt Purification and characterization of a new glutathione S -transferase, class theta, from human erythrocytes ISSX Proc. 7 1995 113
65. B.A. Schwetz B.K.J. Leong P.J. Gehring The effect of maternally inhaled trichloroethylene, perchloroethylene, methyl chloroform, and methylene chloride on embryonal and fetal development in mice and rats Toxicol. Appl. Pharmacol. 32 1975 84 96
66. E.M. Sellers M. Lang J. Koch-Weser E. LeBlanc H. Kalant Interaction of chloral hydrate and ethanol in man. I. Metabolism Clin. Pharmacol. Therap. 13 1972 37 49
67. E.M. Sellers M. Lang-Sellers J. Koch-Weser Comparative metabolism of chloral hydrate and trichlofos J. Clin. Pharmacol. 18 1978 457 461
68. A.L. Sharpe D.E. Carter Substrate specificity of rat liver aldehyde dehydrogenase with chloroacetaldehydes J. Biochem. Toxicol. 8 1993 155 160
69. T. Shimada H. Yamazaki M. Mimura Y. Inui F.P. Guengerich Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians J. Pharmacol. Exp. Ther. 270 1994 414 423
70. J. Shultz H. Weiner Alteration of the enzymology of chloral hydrate reduction in the presence of ethanol Biochem. Pharmacol. 28 1979 3379 3384
71. N.E. Sladek C.L. Manthey P.A. Maki Z. Zhang G.J. Landkamer Xenobiotic oxidation catalyzed by aldehyde dehydrogenases Drug Metab. Rev. 20 1989 697 720
72. M.K. Smith J.L. Randall E.J. Read J.A. Stober Teratogenic activity of trichloroacetic acid in the rat Teratology 40 1989 445 451
73. E.L. Stephens J.A. Taylor N. Kaplan C.H. Yang L.L. Hsieh G.W. Lucier D.A. Bell Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese Pharmacogenetics 4 1994 185 192
74. B. Tabakoff C. Vugrincic R. Anderson S.G.A. Alivisatos Reduction of chloral hydrate to trichloroethanol in brain extracts Biochem. Pharmacol. 23 1974 455 460
75. D.H. Taylor K.E. Lagory D.J. Zaccaro R.J. Pfohl R.D. Laurie Effect of trichloroethylene on the exploratory and locomotor activity of rats exposed during development Sci. Total Environ. 47 1985 415 420
76. R. Thier U. Fost S. Deutschmann K.R. Schroder G. Westphal E. Hallier H. Peter Ethics of cardiovascular medicine (keynote address), 21st Bethesda Conference Arch. Toxicol. 14 1991 254 258
77. A.N. Tucker V.M. Sanders D.W. Barnes T.J. Bradshaw K.L. White L.E. Sain J.F. Borzelleca A.E. Munson Toxicology of trichloroethylene in the mouse Toxicol. Appl. Pharmacol. 62 1982 351 357
78. F. Uematsu H. Kikuchi M. Motomiya T. Abe L. Sagami T. Ohmachi A. Wakui R. Kanamaru M. Watanabe Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to lung cancer Jpn. J. Cancer Res. 82 1991 254 256
79. K. Watanabe S. Narimatsu I. Yamamoto H. Yoshimura Hepatic microsomal oxygenation of aldehydes to carboxylic acids Biochem. Biophys. Res. Commun. 166 1990 1308 1312
80. K. Watanabe S. Narimatsu I. Yamamoto H. Yoshimura Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P-450 isozyme J. Biol. Chem. 266 1991 2709 2711
81. P.G. Wells G.W. Moore D. Rabin G.K. Wilkinson J.A. Oates P.W. Stacpoole Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans Diabetologia 19 1980 109 113
82. J.R. Withey B.T. Collins P.G. Collins Effect of vehicle on the pharmacokinetics and uptake of four halogenated hydrocarbons from the gastrointestinal tract of the rat J. Appl. Toxicol. 3 1983 249 254
83. A. Yoshida Molecular genetics of human aldehyde dehydrogenase Pharmacogenetics 2 1992 139 147
84. H. Zenick E. Blackburn N. Richardale M.K. Smith Effects of trichloroethylene exposure on male reproductive function in rats Toxicology 31 1984 237 250