CD44 standard and variant isoform expression in human epidermal skin tumors is not correlated with tumor aggressiveness but down-regulated during proliferation and tumor de-differentiation

International Journal of Cancer

Volumn 69, Issue 3, 1996, Pages 218-224

  Seelentag, Walter K F ^a   Günthert, Ursula ^b   Saremaslani, Parvin ^a   Futo, Eva ^a   Pfaltz, Madeleine ^a   Heitz, Philipp U ^a   Roth, Jürgen ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN;

ARTICLE; BASAL CELL CARCINOMA; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN TISSUE; KERATOACANTHOMA; PRIORITY JOURNAL; SEBORRHEIC KERATOSIS; SKIN PAPILLOMA; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; TUMOR DIFFERENTIATION;

ANIMALS; ANTIGENS, CD44; CARCINOMA, BASAL CELL; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CELL DIVISION; DOWN-REGULATION; EXONS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOMERISM; KERATOACANTHOMA; MICE; SKIN; SKIN NEOPLASMS;

EID: 0030035585     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960621)69:3<218::AID-IJC12>3.0.CO;2-3     Document Type: Article

References (27)

1. ABBASI, A.M., CHESTER, K.A., TALBOT, I.C., MACPHERSON, A.S., BOXER, G., FORBES, A., MALCOLM, A.D. and BEGENT, R.H., CD44 is associated with proliferation in normal and neoplastic human colorectal epithelial cells. Europ. J. Cancer, 29A, 1995-2002 (1993).
2. ADAMS, J.C., Heavy metal intensification of DAB-based HRP reaction product. J. Histochem. Cytochem., 29, 775 (1981).
3. ALBELDA, S.M., Biology of disease: role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab. Invest., 68, 4-17 (1993).
4. DALL, P., HEIDER, K.H., HEKELE, A., VON MINCKWITZ, G., KAUFMANN, M., PONTA, H. and HERRLICH, P., Surface protein expression and messenger RNA-splicing analysis of CD44 in uterine cervical cancer and normal cervical epithelium. Cancer Res., 54, 3337-3341 (1994).
5. FOX, S.B., FAWCETT, J., JACKSON, D.G., COLLINS, I., GATTER, K.C., HARRIS, A.L., GEARING, A. and SIMMONS, D.L., Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms. Cancer Res., 54, 4539-4546 (1994).
6. FRIEDRICHS, K., FRANKE, F., LISBOA, B.-W., KÜGLER, G., GILLE, I., TERPE, H.J., HÖLZEE, F., MAASS, H. and GÜNTHERT, U., CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer. Cancer Res., 55, 5424-5433 (1995a).
7. FRIEDRICHS, K., KÜGLER, G., FRANKE, F., TERPE, H.J., ARIT, J., REGIDOR, P.A. and GÜNTHERT, U., CD44 isoforms in prognosis of breast cancer. Lancet, 345, 1237 (1995b).
8. GHADIALLY, F.N., Keratoacanthoma. In: T.B. Fitzpatrick, A.Z. Eisen, K. Wolff, I.M. Freedberg and K.F. Austen (eds.), Dermatology in general medicine, pp. 383-389, McGraw-Hill, New York (1979).
9. GÜNTHERT, U., CD44: a multitude of isoforms with diverse functions. Curr. Topics Microbiol. Immunol., 184, 47-63 (1993).
10. GÜNTHERT, U., CD44 in malignant disorders. Curr. Topics Microbiol. Immunol., (1996) (In press).
11. GÜNTHERT, U., STAUDER, R., MAYER, B., TERPE, H.J., FINKE, L. and FRIEDRICHS, K., Are CD44 variant isoforms involved in human tumour progression? Cancer Surv., 24, 19-42 (1995).
12. KAUFMANN, M., HEIDER, K.H., SINN, H., VON MINCKWITZ, G., PONTA, H. and HERRLICH, P., CD44 variant exon epitopes in primary breast cancer and length of survival. Lancet, 345, 615-619 (1995).
13. KOOPMAN, G., HEIDER, K.H., HORST, E., ADOLF, G.R., VAN DEN BERG, F., PONTA, H., HERRLICH, P. and PALS, S.T., Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44. J. exp. Med., 177, 897-904 (1993).
14. KORETZ, K., MOLLER, P., LEHNERT, T., HINZ, U., OTTO, H.F. and HERFARTH, C., Effect of CD44v6 on survival in colorectal carcinoma [letter]. Lancet, 345, 327-328 (1995).
15. MACKAY, C.R., TERPE, H.J., STAUDER, R., MARSTON, W.L., STARK, H. and GÜNTHERT, U., Expression and modulation of CD44 variant isoforms in humans. J. Cell Biol., 124, 71-82 (1994).
16. MAYER, B., JAUCH, K.W., GÜNTHERT, U., FIGDOR, C.G., SCHILDBERG, F.W., FUNKE, I. and JOHNSON, J.P., De-novo expression of CD44 and survival in gastric cancer. Lancet, 342, 1019-1022 (1993).
17. MIKHAIL, G.R., NIMS, L.P., KELLY, A.P., JR., DITMARS, D.M., JR. and EYLER, W.R., Metastatic basal cell carcinoma: review, pathogenesis, and report of two Cases. Arch. Dermatol., 113, 1261-1269 (1977).
18. MOLLER, R., REYMANN, F. and HOU JENSEN, K., Metastases in dermatological patients with squamous cell carcinoma. Arch. Dermatol., 115, 703-705 (1979).
19. MULDER, J.W., KRUYT, P.M., SEWNATH, M., OOSTING, J., SELDENRIJK, C.A., WEIDEMA, W.F., OFFERHAUS, G.J. and PALS, S.T., Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins. Lancet, 344, 1470-1472 (1994).
20. PENNEYS, N.S., CD44 expression in normal and inflamed skin. J. Cutan. Pathol., 20, 250-253 (1993).
21. SALMI, M., GRON VIRTA, K., SOINTU, P., GRENMAN, R., KALIMO, H. and JALKANEN, S., Regulated expression of exon v6 containing isoforms of CD44 in man: downregulation during malignant transformation of tumors of squamocellular origin. J. Cell Biol., 122, 431-442 (1993).
22. SEELENTAG, W.K.F., GÜNTHERT, U., SAREMASLANI, P., FUTO, E., HEITZ, P.U. and ROTH, J., Correlation of CD44 isoform expression with histological grading in human neoplasms [abstract]. Pathol. Res. Pract., 191, 774 (1995).
23. STAUDER, R., EISTERER, W., THAEER, J. and GÜNTHERT, U., CD44 variant isoforms in non-Hodgkin's lymphoma: a new independent prognostic factor. Blood, 85, 2885-2899 (1995).
24. STAUDER, R. and GÜNTHERT, U., CD44 isoforms: impact on lymphocyte activation and differentiation. Immunologist, 3, 78-83 (1995).
25. TERPE, H.J., STARK, H., PREHM, P. and GÜNTHERT, U., CD44 variant isoforms are preferentially expressed in basal epithelia of non-malignant human fetal and adult tissues. Histochemistry, 101, 79-89 (1994).
26. VAN DEN BERG, F.M., BAAS, I.O., POLAK, M.M. and OFFERHAUS, G.J., Detection of p53 overexpression in routinely paraffin-embedded tissue of human carcinomas using a novel target unmasking fluid. Amer. J. Pathol., 142, 381-385 (1993).
27. YASAKA, N., FURUE, M. and TAMAKI, K., CD44 expression in normal human skin and skin tumors. J. Dermatol., 22, 88-94 (1995).