메뉴 건너뛰기




Volumn 53, Issue 2, 1996, Pages 151-160

Antisense strategies and therapeutic applications

Author keywords

Allergies; Arthritis; Gene therapy; Genetic engineering; Hepatitis B infections; HIV infections; Neoplasms; Oligonucleotides; Papillomavirus infections; Restenosis

Indexed keywords

ANTIGENE SEQUENCE; ANTISENSE OLIGONUCLEOTIDE; DOUBLE STRANDED DNA; DRUG CARRIER; LIPOSOME; MESSENGER RNA; NANOPARTICLE; NUCLEASE; POLYMER; RIBOZYME; UNCLASSIFIED DRUG;

EID: 0030035031     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajhp/53.2.151     Document Type: Article
Times cited : (36)

References (76)
  • 1
    • 11944267365 scopus 로고
    • Antisense oligonucleotides: A new therapeutic principle
    • Uhlmann E, Peyman A. Antisense oligonucleotides: a new therapeutic principle. Chem Rev. 1990; 90:543-4.
    • (1990) Chem Rev. , vol.90 , pp. 543-544
    • Uhlmann, E.1    Peyman, A.2
  • 2
    • 0021742961 scopus 로고
    • Translationally associated helix-destabilizing activity in rabbit reticulocyte lysate
    • Liebhaber SA, Cash FE, Shakin SH. Translationally associated helix-destabilizing activity in rabbit reticulocyte lysate. J Biol Chem. 1984; 259:15597-602.
    • (1984) J Biol Chem. , vol.259 , pp. 15597-15602
    • Liebhaber, S.A.1    Cash, F.E.2    Shakin, S.H.3
  • 3
    • 0024041180 scopus 로고
    • Role of RNase H in hybrid-arrested translation by antisense oligonucleotides
    • Walder RY, Walder JA Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. Proc Natl Acad Sci U S A. 1988; 85:5011-5.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 5011-5015
    • Walder, R.Y.1    Walder, J.A.2
  • 4
    • 0025058003 scopus 로고
    • Site-specific inhibition of EcoRI restriction/modification enzymes by a DNA triple helix
    • Hanvey JC, Shimizu M, Wells RD. Site-specific inhibition of EcoRI restriction/modification enzymes by a DNA triple helix. Nucleic Acids Res. 1990; 18:157-61.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 157-161
    • Hanvey, J.C.1    Shimizu, M.2    Wells, R.D.3
  • 5
    • 0026349087 scopus 로고
    • The anti-gene strategy: Control of gene expression by triplex-forming oligonucleotides
    • Helene C. The anti-gene strategy: control of gene expression by triplex-forming oligonucleotides. Anticancer Drug Des. 1991; 6:569-74.
    • (1991) Anticancer Drug Des. , vol.6 , pp. 569-574
    • Helene, C.1
  • 6
    • 0026336817 scopus 로고
    • Oligonucleotides as therapeutic agents
    • Cohen JS. Oligonucleotides as therapeutic agents. Pharmacol Ther. 1991; 52:221-5.
    • (1991) Pharmacol Ther. , vol.52 , pp. 221-225
    • Cohen, J.S.1
  • 7
    • 0023221419 scopus 로고
    • A small catalytic oligoribonucleotide
    • Uhlenbeck OC. A small catalytic oligoribonucleotide. Nature. 1987; 328:596-610
    • (1987) Nature , vol.328 , pp. 596-610
    • Uhlenbeck, O.C.1
  • 8
    • 0026523627 scopus 로고
    • Ribozymes as anti-HIV therapeutic agents: Principles, applications, and problems
    • Rossi JJ, Elkins D, Zaia JA et al. Ribozymes as anti-HIV therapeutic agents: principles, applications, and problems. AIDS Res Hum Retroviruses. 1992; 8:183-9.
    • (1992) AIDS Res Hum Retroviruses , vol.8 , pp. 183-189
    • Rossi, J.J.1    Elkins, D.2    Zaia, J.A.3
  • 9
    • 0025968051 scopus 로고
    • Ribozymes that cleave an RNA sequence from human immunodeficiency virus: The effect of flanking sequence on rate
    • Goodchild J, Kohli V. Ribozymes that cleave an RNA sequence from human immunodeficiency virus: the effect of flanking sequence on rate. Arch Biochem Biophys. 1991; 284:386-91.
    • (1991) Arch Biochem Biophys. , vol.284 , pp. 386-391
    • Goodchild, J.1    Kohli, V.2
  • 10
    • 0025051353 scopus 로고
    • Ribozymes correctly cleave a model substrate and endogenous RNA in vivo
    • Saxena SK, Ackerman EJ. Ribozymes correctly cleave a model substrate and endogenous RNA in vivo. J Biol Chem. 1990; 265:17106-9.
    • (1990) J Biol Chem. , vol.265 , pp. 17106-17109
    • Saxena, S.K.1    Ackerman, E.J.2
  • 11
    • 0026175538 scopus 로고
    • Ribozyme-mediated cleavage of an HIV-1 gag RNA: The effects of non-targeted sequences and secondary structure on ribozyme cleavage activity
    • Taylor N, Rossi JJ. Ribozyme-mediated cleavage of an HIV-1 gag RNA: the effects of non-targeted sequences and secondary structure on ribozyme cleavage activity. Antisense Res Dev. 1991; 1:173-86.
    • (1991) Antisense Res Dev. , vol.1 , pp. 173-186
    • Taylor, N.1    Rossi, J.J.2
  • 12
    • 0001477721 scopus 로고
    • Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA
    • Zamecnik PC, Goodchild Y, Taguchi Y et al. Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA. Proc Natl Acad Sci U S A. 1986; 83:4143-6.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 4143-4146
    • Zamecnik, P.C.1    Goodchild, Y.2    Taguchi, Y.3
  • 13
    • 0023755696 scopus 로고
    • Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus
    • Agrawal S, Goodchild J, Civeira MP et al. Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus. Proc Natl Acad Sci U S A. 1988; 85:7079-83.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 7079-7083
    • Agrawal, S.1    Goodchild, J.2    Civeira, M.P.3
  • 14
    • 0001476029 scopus 로고    scopus 로고
    • Inhibition of acquired immunodeficiency syndrome virus by oligodeoxynucleoside methylphosphonates
    • Sarin PS, Agrawal S, Civeira MP et al. Inhibition of acquired immunodeficiency syndrome virus by oligodeoxynucleoside methylphosphonates. Proc Natl Acad Sci U S A. 1998; 85:7448-51.
    • (1998) Proc Natl Acad Sci U S A , vol.85 , pp. 7448-7451
    • Sarin, P.S.1    Agrawal, S.2    Civeira, M.P.3
  • 15
    • 0023447274 scopus 로고
    • Phosphorothioate analogs of oligodeoxynucleotides: Inhibitors of replication and cytopathic effects of human immunodeficiency virus
    • Matsukura M, Shinozuka K, Zon G et al. Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus. Proc Natl Acad Sci U S A. 1987; 84:7706-10.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 7706-7710
    • Matsukura, M.1    Shinozuka, K.2    Zon, G.3
  • 16
    • 0025552906 scopus 로고
    • Innovations in the use of antisense oligonucleotides
    • Zon G. Innovations in the use of antisense oligonucleotides. Ann N Y Acad Sci. 1990; 616:161-72.
    • (1990) Ann N Y Acad Sci. , vol.616 , pp. 161-172
    • Zon, G.1
  • 17
    • 0000600241 scopus 로고
    • Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev(art/trs) in chronically infected cells
    • Matsukura M, Zon G, Shinozuka K et al. Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev(art/trs) in chronically infected cells. Proc Natl Acad Sci U S A. 1989; 86:4244-8.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 4244-4248
    • Matsukura, M.1    Zon, G.2    Shinozuka, K.3
  • 18
    • 0001717745 scopus 로고
    • Ribozyme-mediated sitespecific cleavage of the HIV-1 genome
    • Chang P, Cantin EM, Zaia JA et al. Ribozyme-mediated sitespecific cleavage of the HIV-1 genome. Clin Biotechnol. 1990; 2:23-31.
    • (1990) Clin Biotechnol. , vol.2 , pp. 23-31
    • Chang, P.1    Cantin, E.M.2    Zaia, J.A.3
  • 19
    • 0025021952 scopus 로고
    • Hairpin catalytic RNA model: Evidence for helices and sequence requirement for substrate RNA
    • Hampel A, Tritz R, Hicks M et al. Hairpin catalytic RNA model: evidence for helices and sequence requirement for substrate RNA. Nucleic Acids Res. 1990; 18:299-304.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 299-304
    • Hampel, A.1    Tritz, R.2    Hicks, M.3
  • 20
    • 0025347975 scopus 로고
    • A randomized, controlled trial of Interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B
    • Perillo RP, Schiff ER, Davie GL et al. A randomized, controlled trial of Interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. N Engl J Med. 1990; 323:295-301.
    • (1990) N Engl J Med. , vol.323 , pp. 295-301
    • Perillo, R.P.1    Schiff, E.R.2    Davie, G.L.3
  • 22
    • 0027528518 scopus 로고
    • In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate modified antisense oligodeoxynucleotides
    • Offensperger WB, Offensperger S, Walter E et al. In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate modified antisense oligodeoxynucleotides. EMBO J. 1993; 12:1257-62.
    • (1993) EMBO J. , vol.12 , pp. 1257-1262
    • Offensperger, W.B.1    Offensperger, S.2    Walter, E.3
  • 23
    • 0026688793 scopus 로고
    • Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides
    • Wu GY, Wu CH. Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides. J Biol Chem. 1992; 267:12436-9.
    • (1992) J Biol Chem. , vol.267 , pp. 12436-12439
    • Wu, G.Y.1    Wu, C.H.2
  • 24
    • 0007684104 scopus 로고
    • Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4
    • Kulka M, Smith CC, Aurelian L et al. Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4. Proc Natl Acad Sci U S A. 1989; 86:6868-72.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 6868-6872
    • Kulka, M.1    Smith, C.C.2    Aurelian, L.3
  • 25
    • 0027103753 scopus 로고
    • Epstein-Barr viral latency and cell immortalization as targets for antisense oligomers
    • Pagano JS, Jimenez G, Sung NS et al. Epstein-Barr viral latency and cell immortalization as targets for antisense oligomers. Ann N Y Acad Sci. 1992; 660:107-16.
    • (1992) Ann N Y Acad Sci. , vol.660 , pp. 107-116
    • Pagano, J.S.1    Jimenez, G.2    Sung, N.S.3
  • 26
    • 0027399409 scopus 로고
    • In vitro evaluation of phosphorothioate oligonucleotides targeted to the E2 mRNA of papillomavirus: Potential treatment for genital warts
    • Cowsert LM, Fox MC, Zon G et al. In vitro evaluation of phosphorothioate oligonucleotides targeted to the E2 mRNA of papillomavirus: potential treatment for genital warts. Antimicrob Agents Chemother. 1993; 37:171-7.
    • (1993) Antimicrob Agents Chemother. , vol.37 , pp. 171-177
    • Cowsert, L.M.1    Fox, M.C.2    Zon, G.3
  • 27
    • 0027267552 scopus 로고
    • Antisense technology: Biological utility and practical considerations
    • Neckers L, Whitesell L. Antisense technology: biological utility and practical considerations. Am J Physiol. 1993; 9:L1-12.
    • (1993) Am J Physiol. , vol.9
    • Neckers, L.1    Whitesell, L.2
  • 28
    • 0027314371 scopus 로고
    • Antisense technology for cancer therapy: Does it make sense?
    • Carter G, Lemoine NR. Antisense technology for cancer therapy: does it make sense? Br J Cancer. 1993; 67:869-76.
    • (1993) Br J Cancer , vol.67 , pp. 869-876
    • Carter, G.1    Lemoine, N.R.2
  • 29
    • 0026041988 scopus 로고
    • Inhibition of protooncogene expression by antisense oligodeoxynucleotides: Biological and therapeutic implications
    • Calabretta B. Inhibition of protooncogene expression by antisense oligodeoxynucleotides: biological and therapeutic implications. Cancer Res. 1991; 51:4505-10.
    • (1991) Cancer Res. , vol.51 , pp. 4505-4510
    • Calabretta, B.1
  • 30
    • 0025124267 scopus 로고
    • A potential role for antisense oligonucleotide analogues in the development of oncogene targeted cancer chemotherapy
    • Tidd DM. A potential role for antisense oligonucleotide analogues in the development of oncogene targeted cancer chemotherapy. Anticancer Res. 1990; 10:1169-82.
    • (1990) Anticancer Res. , vol.10 , pp. 1169-1182
    • Tidd, D.M.1
  • 31
    • 0023954113 scopus 로고
    • An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyocytic cells and induces differentiation
    • Holt JT, Redner RL, Nienhuis AW. An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyocytic cells and induces differentiation. Mol Cell Biol. 1988; 8:963-73.
    • (1988) Mol Cell Biol. , vol.8 , pp. 963-973
    • Holt, J.T.1    Redner, R.L.2    Nienhuis, A.W.3
  • 32
    • 0028935119 scopus 로고
    • Alterations of c-myc expression by antisense oligodeoxynucleotides enhance the induction of apoptosis in HL-60 cells
    • Kimura S, Maekawa T, Hirakawa K et al. Alterations of c-myc expression by antisense oligodeoxynucleotides enhance the induction of apoptosis in HL-60 cells. Cancer Res. 1995; 55:1379-84.
    • (1995) Cancer Res. , vol.55 , pp. 1379-1384
    • Kimura, S.1    Maekawa, T.2    Hirakawa, K.3
  • 33
    • 0025312339 scopus 로고
    • Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide
    • McManaway ME, Neckers LM, Loke SL et al. Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide. Lancet. 1990; 335:808-11.
    • (1990) Lancet , vol.335 , pp. 808-811
    • McManaway, M.E.1    Neckers, L.M.2    Loke, S.L.3
  • 34
    • 0025050969 scopus 로고
    • Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line
    • Rosolen A, Whitesell L, Ikegaki N et al. Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line. Cancer Res. 1990; 50:6316-22.
    • (1990) Cancer Res. , vol.50 , pp. 6316-6322
    • Rosolen, A.1    Whitesell, L.2    Ikegaki, N.3
  • 35
    • 0026031868 scopus 로고
    • Episome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines
    • Whitesell L, Rosolen A, Neckers LM. Episome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines. Mol Cell Biol. 1991; 11:1360-1.
    • (1991) Mol Cell Biol. , vol.11 , pp. 1360-1361
    • Whitesell, L.1    Rosolen, A.2    Neckers, L.M.3
  • 36
    • 0040668827 scopus 로고
    • Anoligomer complementary to c-myb encoded mRNA inhibits proliferation of human myeloid leukemia cell lines
    • Anfossi G, Gerwirtz AM, Calabretta B. Anoligomer complementary to c-myb encoded mRNA inhibits proliferation of human myeloid leukemia cell lines. Proc Natl Acad Sci U S A. 1989; 86:3379-83.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 3379-3383
    • Anfossi, G.1    Gerwirtz, A.M.2    Calabretta, B.3
  • 37
    • 0026089494 scopus 로고
    • Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: An in vitro study with relevance to bone marrow purging
    • Calabretta B, Sims RB, Valtieri M et al. Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study with relevance to bone marrow purging. Proc Natl Acad Sci U S A. 1991; 88:2351-5.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2351-2355
    • Calabretta, B.1    Sims, R.B.2    Valtieri, M.3
  • 38
    • 0028580610 scopus 로고
    • Treatment of chronic myelogenous leukemia (CML) with c-myb antisense oligodeoxynucleotides
    • Gewirtz AM. Treatment of chronic myelogenous leukemia (CML) with c-myb antisense oligodeoxynucleotides. Bone Marrow Transplant. 1994; 14(Suppl 3):S57-61.
    • (1994) Bone Marrow Transplant , vol.14 , Issue.3 SUPPL.
    • Gewirtz, A.M.1
  • 39
    • 0010535148 scopus 로고
    • Autografting for chronic myelogenous leukemia (Cml) with c-myb antisense oligodeoxynucleotide purged bone marrow: A preliminary report
    • Abstract
    • Luger SM, Ratajczak MZ, Stadtmauer EA et al. Autografting for chronic myelogenous leukemia (Cml) with c-myb antisense oligodeoxynucleotide purged bone marrow: a preliminary report Blood. 1994; 84:(Suppl 1):151. Abstract.
    • (1994) Blood , vol.84 , Issue.1 SUPPL. , pp. 151
    • Luger, S.M.1    Ratajczak, M.Z.2    Stadtmauer, E.A.3
  • 40
    • 0028243005 scopus 로고
    • The basis of molecular strategies for treating coronary restenosis after angioplasty
    • Epstein ST, Speir E, Unger EF et al. The basis of molecular strategies for treating coronary restenosis after angioplasty. J Am Coll Cardiol. 1994; 23:1278-88.
    • (1994) J Am Coll Cardiol. , vol.23 , pp. 1278-1288
    • Epstein, S.T.1    Speir, E.2    Unger, E.F.3
  • 41
    • 0026612517 scopus 로고
    • The restenosis paradigm revisted: An alternative proposal for cellular mechanisms
    • Schwartz RS, Holmes DR, Topol EJ. The restenosis paradigm revisted: an alternative proposal for cellular mechanisms. J Am Coll Cardiol. 1992; 20:1284-93.
    • (1992) J Am Coll Cardiol. , vol.20 , pp. 1284-1293
    • Schwartz, R.S.1    Holmes, D.R.2    Topol, E.J.3
  • 42
    • 0026773852 scopus 로고
    • Inhibition of smooth muscle cell proliferation by an antisense oligodeoxynucleotide targeting the mRNA encoding PCNA
    • Speir E, Epstein SE. Inhibition of smooth muscle cell proliferation by an antisense oligodeoxynucleotide targeting the mRNA encoding PCNA. Circulation. 1992; 86:538-47.
    • (1992) Circulation , vol.86 , pp. 538-547
    • Speir, E.1    Epstein, S.E.2
  • 43
    • 0000392167 scopus 로고
    • Inhibition of proliferation of human vascular smooth muscle cells using antisense oligonucleotides to PCNA
    • Abstract
    • Pickering G, Weir L, Jekanowski J et al. Inhibition of proliferation of human vascular smooth muscle cells using antisense oligonucleotides to PCNA. J Am Coll Cardiol. 1992; 19:165. Abstract.
    • (1992) J Am Coll Cardiol. , vol.19 , pp. 165
    • Pickering, G.1    Weir, L.2    Jekanowski, J.3
  • 44
    • 0027506930 scopus 로고
    • Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration
    • Biro S, Fu YM, Yu ZX et al. Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration. Proc Natl Acad Sci U S A. 1993; 90:654-8.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 654-658
    • Biro, S.1    Fu, Y.M.2    Yu, Z.X.3
  • 45
    • 0027293123 scopus 로고
    • Downregulation of c-myc expression by antisense oligonucleotides inhibits proliferation of human smooth muscle cells
    • Shi Y, Hutchinson HG, Hall DJ et al. Downregulation of c-myc expression by antisense oligonucleotides inhibits proliferation of human smooth muscle cells. Circulation. 1993; 88:1190-5.
    • (1993) Circulation , vol.88 , pp. 1190-1195
    • Shi, Y.1    Hutchinson, H.G.2    Hall, D.J.3
  • 46
    • 0026536410 scopus 로고
    • Antisense nonmuscle myosin heavy chain and c-myb oligonucleotides suppress smooth muscle cell proliferation in vitro
    • Simons M, Rosenberg RD. Antisense nonmuscle myosin heavy chain and c-myb oligonucleotides suppress smooth muscle cell proliferation in vitro. Circ Res. 1992; 70:835-43.
    • (1992) Circ Res. , vol.70 , pp. 835-843
    • Simons, M.1    Rosenberg, R.D.2
  • 47
    • 0028219485 scopus 로고
    • Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides
    • Bennett MR, Anglin S, McEwan JR et al. Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides. J Clin Invest. 1994; 93:820-8.
    • (1994) J Clin Invest. , vol.93 , pp. 820-828
    • Bennett, M.R.1    Anglin, S.2    McEwan, J.R.3
  • 48
    • 0028215639 scopus 로고
    • Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides
    • Morishita R, Gibbons GH, Ellison KE et al. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest. 1994; 93:1458-64.
    • (1994) J Clin Invest. , vol.93 , pp. 1458-1464
    • Morishita, R.1    Gibbons, G.H.2    Ellison, K.E.3
  • 49
    • 0025695743 scopus 로고
    • Interleukin-1-induced interleukin-6 is required for the inhibition of proteoglycan synthesis by interleukin-1 in human articular cartilage
    • Nietfeld JJ, Wilbrink B, Helle M et al. Interleukin-1-induced interleukin-6 is required for the inhibition of proteoglycan synthesis by interleukin-1 in human articular cartilage. Arthritis Rheum. 1990; 33:1695-701.
    • (1990) Arthritis Rheum. , vol.33 , pp. 1695-1701
    • Nietfeld, J.J.1    Wilbrink, B.2    Helle, M.3
  • 50
    • 0028020955 scopus 로고
    • Antisense oligonucleotides, a novel tool for the control of cytokine effects on human cartilage
    • Nietfeld JJ, Duits AJ, Tilanus MGJ et al. Antisense oligonucleotides, a novel tool for the control of cytokine effects on human cartilage. Arthritis Rheum. 1994; 37:1357-62.
    • (1994) Arthritis Rheum. , vol.37 , pp. 1357-1362
    • Nietfeld, J.J.1    Duits, A.J.2    Tilanus, M.G.J.3
  • 51
    • 0026458274 scopus 로고
    • Specific inhibition of IgE antibody production by an antisense oligodeoxynucleotide oligomer
    • Hall TJ, Brostoff J. Specific inhibition of IgE antibody production by an antisense oligodeoxynucleotide oligomer. Immunology. 1992; 77:462-4.
    • (1992) Immunology , vol.77 , pp. 462-464
    • Hall, T.J.1    Brostoff, J.2
  • 52
    • 0022780091 scopus 로고
    • Oligodeoxynucleotide stability in subcellular extracts and culture media
    • Wickstrom E. Oligodeoxynucleotide stability in subcellular extracts and culture media. J Biochem Biophys Methods. 1986; 13:97-102.
    • (1986) J Biochem Biophys Methods , vol.13 , pp. 97-102
    • Wickstrom, E.1
  • 53
    • 0026002671 scopus 로고
    • Stability of modified antisense oligodeoxynucleotides in cellular extracts and sera
    • Akhtar S, Kole R, Juliano RL. Stability of modified antisense oligodeoxynucleotides in cellular extracts and sera. Life Sci. 1991; 49:1793-801.
    • (1991) Life Sci. , vol.49 , pp. 1793-1801
    • Akhtar, S.1    Kole, R.2    Juliano, R.L.3
  • 54
    • 0026357940 scopus 로고
    • Phosphorothioate oligodeoxynucleotides: Antisense inhibitors of gene expression?
    • Stein CA, Tonkinson JL, Yakobov L. Phosphorothioate oligodeoxynucleotides: antisense inhibitors of gene expression? Pharmacol Ther. 1991; 52:365-74.
    • (1991) Pharmacol Ther. , vol.52 , pp. 365-374
    • Stein, C.A.1    Tonkinson, J.L.2    Yakobov, L.3
  • 55
    • 0028469243 scopus 로고
    • Routine preparation of thiol oligonucleotides: Application to the synthesis of oligonucleotide-peptide hybrids
    • Ede NJ, Tregear GW, Haralambidis J. Routine preparation of thiol oligonucleotides: application to the synthesis of oligonucleotide-peptide hybrids. Bioconjug Chem. 1994; 5:373-8.
    • (1994) Bioconjug Chem. , vol.5 , pp. 373-378
    • Ede, N.J.1    Tregear, G.W.2    Haralambidis, J.3
  • 56
    • 0026920673 scopus 로고
    • Cellular uptake and subcellular distribution of phosphorothioate oligonucleotides into cultured cells
    • Iversen PL, Shu S, Meyer A et al. Cellular uptake and subcellular distribution of phosphorothioate oligonucleotides into cultured cells. Antisense Res Dev. 1992; 2:211-2.
    • (1992) Antisense Res Dev. , vol.2 , pp. 211-212
    • Iversen, P.L.1    Shu, S.2    Meyer, A.3
  • 57
    • 0025552907 scopus 로고
    • Large-scale economic synthesis of antisense phosphorothioate analogues of DNA for preclinical investigations
    • Geiser T. Large-scale economic synthesis of antisense phosphorothioate analogues of DNA for preclinical investigations. Ann N Y Acad Sci. 1990; 616:173-83.
    • (1990) Ann N Y Acad Sci. , vol.616 , pp. 173-183
    • Geiser, T.1
  • 58
    • 0025878768 scopus 로고
    • The potential use of catalytic RNAs in therapy of HIV infection and other diseases
    • Rossi JJ, Cantin EM, Sarver N et al. The potential use of catalytic RNAs in therapy of HIV infection and other diseases. Pharmacol Ther. 1991; 50:245-54.
    • (1991) Pharmacol Ther. , vol.50 , pp. 245-254
    • Rossi, J.J.1    Cantin, E.M.2    Sarver, N.3
  • 59
    • 0028422387 scopus 로고
    • Chemists create new oligonucleotide analogs for 'antisense' applications
    • Apr 18: News
    • Baum R. Chemists create new oligonucleotide analogs for 'antisense' applications. Chem Eng News. 1994; Apr 18:21-2. News.
    • (1994) Chem Eng News , pp. 21-22
    • Baum, R.1
  • 60
    • 0027246678 scopus 로고
    • Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines
    • Wagner RW, Matteucci MD, Lewis JG et al. Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science. 1993; 260:1510-3.
    • (1993) Science , vol.260 , pp. 1510-1513
    • Wagner, R.W.1    Matteucci, M.D.2    Lewis, J.G.3
  • 61
    • 0345570537 scopus 로고
    • Characterization of oligonucleotide transport into living cells
    • Loke SL, Stein CA, Zhang XH et al. Characterization of oligonucleotide transport into living cells. Proc Natl Acad Sci U S A. 1989; 86:3474-8.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 3474-3478
    • Loke, S.L.1    Stein, C.A.2    Zhang, X.H.3
  • 63
    • 0025341615 scopus 로고
    • Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
    • Klibanov AL, Maruyama K, Torchilin VP et al. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 1990; 268:235-7.
    • (1990) FEBS Lett. , vol.268 , pp. 235-237
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3
  • 64
    • 0025731906 scopus 로고
    • Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
    • Allen TM, Hansen C, Martin F et al. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta. 1991; 1066:29-36.
    • (1991) Biochim Biophys Acta , vol.1066 , pp. 29-36
    • Allen, T.M.1    Hansen, C.2    Martin, F.3
  • 66
    • 0028236818 scopus 로고
    • Liposomal delivery of methylphosphonate antisense oligodeoxynucleotides in chronic myelogenous leukemia
    • Tari AM, Tucker SD, Deisseroth A et al. Liposomal delivery of methylphosphonate antisense oligodeoxynucleotides in chronic myelogenous leukemia. Blood. 1994; 84:601-7.
    • (1994) Blood , vol.84 , pp. 601-607
    • Tari, A.M.1    Tucker, S.D.2    Deisseroth, A.3
  • 67
    • 0028026739 scopus 로고
    • Lipofectin-aided cell delivery of ribozyme targeted to human urokinase receptor mRNA
    • Kariko K, Megyen K, Xiao Qi et al. Lipofectin-aided cell delivery of ribozyme targeted to human urokinase receptor mRNA. FEBS Lett. 1994; 352:41-4.
    • (1994) FEBS Lett. , vol.352 , pp. 41-44
    • Kariko, K.1    Megyen, K.2    Qi, X.3
  • 68
    • 0027417416 scopus 로고
    • Delivery of antisense oligonucleotides by poly(L-lysine) conjugation and liposome encapsulation
    • Clarenc JP, Degols G, Leonetti JP et al. Delivery of antisense oligonucleotides by poly(L-lysine) conjugation and liposome encapsulation. Anticancer Drug Des. 1993; 8:81-4.
    • (1993) Anticancer Drug Des. , vol.8 , pp. 81-84
    • Clarenc, J.P.1    Degols, G.2    Leonetti, J.P.3
  • 69
    • 0000738920 scopus 로고
    • Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells
    • Ryser HJP, Shen W-C. Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells. Proc Natl Acad Sci U S A. 1978; 75:3867-70.
    • (1978) Proc Natl Acad Sci U S A , vol.75 , pp. 3867-3870
    • Ryser, H.J.P.1    Shen, W.-C.2
  • 70
    • 0025398291 scopus 로고
    • Biological activity of oligonucleotide-poly(L-lysine) conjugates: Mechanism of cell uptake
    • Leonetti JP, Degols G, Lebleu B. Biological activity of oligonucleotide-poly(L-lysine) conjugates: mechanism of cell uptake. Bioconjug Chem. 1990; 1:149-53.
    • (1990) Bioconjug Chem. , vol.1 , pp. 149-153
    • Leonetti, J.P.1    Degols, G.2    Lebleu, B.3
  • 71
    • 0346551010 scopus 로고
    • Polymer conjugates with anticancer activity
    • Putnam D, Kopecek J. Polymer conjugates with anticancer activity. Adv Polym Sci. 1995; 122:55-123.
    • (1995) Adv Polym Sci. , vol.122 , pp. 55-123
    • Putnam, D.1    Kopecek, J.2
  • 72
    • 0025099302 scopus 로고
    • The potential of water-soluble polymeric carriers in targeted and site-specific drug delivery
    • Kopecek J. The potential of water-soluble polymeric carriers in targeted and site-specific drug delivery. J Controlled Release. 1990; 11:279-90.
    • (1990) J Controlled Release , vol.11 , pp. 279-290
    • Kopecek, J.1
  • 73
    • 0028037219 scopus 로고
    • Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice
    • Schwab G, Chavany C, Duroux I et al. Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice. Proc Natl Acad Sci U S A. 1994; 91:10460-4.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10460-10464
    • Schwab, G.1    Chavany, C.2    Duroux, I.3
  • 75
    • 0025175236 scopus 로고
    • Disposition and metabolism of oligodeoxynucleoside methylphosphonate following a single iv injection in mice
    • Chem TL, Miller P, Ts'O P et al. Disposition and metabolism of oligodeoxynucleoside methylphosphonate following a single iv injection in mice. Drug Metab Dispos Biol Fate Chem. 1990; 18:815-8.
    • (1990) Drug Metab Dispos Biol Fate Chem. , vol.18 , pp. 815-818
    • Chem, T.L.1    Miller, P.2    Ts'O, P.3
  • 76
    • 0027729703 scopus 로고
    • Systemic adminstration of a phosphorothioate oligonucleotide with a sequence complementary to p53 for acute myelogenous leukemia and myelodysplastic syndrome: Initial results of a Phase I trial
    • Bayever E, Iversen PL, Bishop MR et al. Systemic adminstration of a phosphorothioate oligonucleotide with a sequence complementary to p53 for acute myelogenous leukemia and myelodysplastic syndrome: initial results of a Phase I trial. Antisense Res Dev. 1993; 3:383-90.
    • (1993) Antisense Res Dev. , vol.3 , pp. 383-390
    • Bayever, E.1    Iversen, P.L.2    Bishop, M.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.