Total synthesis of bafilomycin A1. 2. The assemblage and completion of the synthesis

Tetrahedron Letters

Volumn 37, Issue 7, 1996, Pages 1073-1076

  Toshima, Kazunobu ^a   Yamaguchi, Hiroyuki ^a   Jyojima, Takaaki ^a   Noguchi, Yasunobu ^a   Nakata, Masaya ^a   Matsumura, Shuichi ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BAFILOMYCIN A1;

ARTICLE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

EID: 0030034540     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(95)02351-8     Document Type: Article

References (31)

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31. 3, δ (TMS), J (Hz)] are the following. 2: 0.67-0.80 (4H, m), 0.98-1.13 (13H, m), 1.01 (3H, d, J = 7.0), 1.05 (3H, d, J = 7.0), 1.17 (3H, d, J = 7.0), 1.68 (3H, s), 1.7-1.8 (2H, m), 1.93 (3H, d, J = 1.3), 2.4-2.55 (2H, m), 2.78 (1H, ddq, J = 9.2, 7.0 and 1.9), 3.31 (3H, s), 3.62 (1H, dd, J = 2.4 and 1.9), 3.65 (3H, s), 3.87 (1H, dd, J = 6.0 and 5.6), 5.31 (1H, dd, J = 5.6 and 5.4), 5.36 (1H, dd, J = 15.2 and 6.0), 5.87 (1H, d, J = 9.2), 5.92 (1H, d, J = 11.0), 6.50 (1H, dd, J = 15.2 and 11.0), 6.62 (1H, s), 9.77 (1H, d, J = 1.8). 19: 0.68-0.80 (4H, m), 0.73 (3H, d, J = 7.2), 0.85 (3H, d, J = 6.9), 0.91 (3H, d, J = 7.0), 0.95-1.12 (22H, m), 0.95 (9H, s), 0.97 (9H, s), 1.16 (3H, d, J = 7.2), 1.65-1.85 (3H, m), 1.66 (3H, s), 1.94 (3H, s), 1.98 (1H, m), 2.20 (1H, m), 2.4-2.55 (2H, m), 2.45 (1H, dd, J = 15.4 and 3.6), 2.80 (1H, dd, J = 15.4 and 10.0), 2.83 (1H, ddq, J = 9.2, 7.0 and 2.2), 3.28 (3H, s), 3.60-3.70 (2H, m), 3.66 (3H, s), 3.81 (1H, ddd, J = 9.8, 4.0 and 2.4), 3.96 (1H, dd, J = 6.0 and 4.0), 4.66 (1H, ddd, J = 10.0, 5.9 and 3.6), 5.29 (1H, dd, J = 4.0 and 2.6), 5.43 (1H, dd, J = 15.6 and 6.0), 5.90 (1H, d, J = 9.2), 5.93 (1H, d, J = 11.2), 6.47 (1H, dd, J = 15.6 and 11.2), 6.68 (1H, s).