Human cytomegalovirus increases constitutive production of interleukin-6 and leukemia inhibitory factor by bone marrow stromal cells

Blood

Volumn 87, Issue 1, 1996, Pages 59-66

  Lagneaux, L ^a   Delforge, A ^b   Snoeck, R ^b   Bosmans, E ^b   Moreau, J F ^b   Taupin, J L ^b   De Clercq, E ^b   Stryckmans, P ^b   Bron, D ^b  

^a JULES BORDET INSTITUTE   (Belgium)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CIDOFOVIR; CYTOMEGALOVIRUS ANTIBODY; GANCICLOVIR; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; LIPOPOLYSACCHARIDE; POLYMYXIN B;

ARTICLE; BONE MARROW SUPPRESSION; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FLOW CYTOMETRY; HEMATOPOIESIS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; INFLAMMATION; PRIORITY JOURNAL; STROMA CELL; VIRUS INACTIVATION; VIRUS ISOLATION; VIRUS REPLICATION;

EID: 0030034299     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.1.59.59     Document Type: Article

References (40)

1. Jacobson MA, Mills J: Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS), Clinical findings, diagnosis and treatment. Ann Intern Med 108:585, 1988
2. Wingard JR, Chen DH, Burns WH, Fuller DJ, Braine HG, Yeager AM, Kaiser H, Burke PJ, Graham ML, Santos GW, Saral R: Cytomegalovirus infection after autologous bone marrow transplantation with comparison to infection after allogeneic bone marrow transplantation. Blood 71:1432, 1988
3. Apperley JF, Goldman JM: Cytomegalovirus: Biology, clinical features and methods for diagnosis. Bone Marrow Transplantation 3:253, 1988
4. Mutter W, Reddhehase MJ, Busch FW, Buhring HJ, Kozinowski VH: Failure in generating hematopoietic stem cell is the primary cause of death from cytomegalovirus disease in immunocompromized host. J Exp Med 167:1645, 1988
5. Verdonck LF, de Gast GC, Van Heugten HG, Nieuwenhuis HK, Dekker AW: Cytomegalovirus infection causes delayed platelet recovery after bone marrow transplantation Blood 78:844, 1991
6. Reiser H, Kuhn J, Doerr HW, Kirchner H, Mink K, Braun R: Human cytomegalovirus replicates in primary human bone marrow cells. J Gen Virol 67:2595, 1986
7. Maciejewski JP, Bruening EE, Donahue RE, Mocarski ES, Young NS, St Jeor SC: Infection of hematopoietic progenitor cells by human cytomegalovirus. Blood 80:170, 1992
8. Rakusan TA, Juneja HS, Fleishmann WR: Inhibition of hemopoietic colony formation by human cytomegalovirus in vitro. J Infect Dis 159:127, 1989
9. MacKintosh FR, Adlish J, Hall SW, St Jeor S, Smith E, Tavassoli M, Zanjani ED: Suppression of normal human hematopoiesis by cytomegalovirus in vitro. Exp Hematol 21:243, 1993
10. Lagneaux L, Delforge A, Snoeck R, Stryckmans P, Bron D: Decreased production of cytokines after cytomegalovirus infection of marrow-derived stromal cells. Exp Hematol 22:26, 1994
11. Dorshkind K: Regulation of hemopoiesis by bone marrow stromal cells and their products. Annu Rev Immunol 8:111, 1990
12. Kittler E, McGrath H, Temeles D, Crittenden R, Kister V, Quesenberry P: Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma. Blood 79:3168, 1992
13. Kishimoto T: The biology of interleukin-6. Blood 74:1, 1989
14. Van Damme J, Schaafsma M, Fibbe W, Falkenburg J, Opdenakker G, Billiau A: Simultaneous production of interleukin 6, interferon-β and colony-stimulating activity by fibroblasts after viral and bacterial infection. Eur J Immunol 19:163, 1989
15. Wetzler M, Kurzrock R, Lowe D, Kantarjian H, Gutterman J, Talpaz M: Alteration in bone marrow adherent layer growth factor expression: A novel mechanism of chronic myelogenous leukemia progression. Blood 78:2400, 1991
16. Lord KA, Abdollahi A, Thomas SM, De Marco M, Brugge JS, Hofforman-Libermann DA: Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation upon induction of myeloid leukemia differentiation. Mol Cell Biol 11:4371, 1991
17. Lagneaux L, Delforge A, Dorval C, Bron D, Stryckmans P: Excessive production of transforming growth factor-β by bone marrow stromal cells in B-cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production. Blood 82:2379, 1993
18. Mar EC, Chiou JF, Cheng YC, Hua,g ES: Inhibition of cellular DNA polymerase a and human cytomegalovirus induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl) guanine and 9-(1,3-dihydroxy-2-propoxymethyl) guanine. J Virol 53:776, 1985
19. Snoeck R, Sakuma T, De Clercq E, Rosenberg Y, Holy A: (S)-1-(3-hydroxy-2-phophonyl methoxypropyl) cytosine a potent and selective inhibitor of human cytomegalovirus replication. Antimicrob Agents Chemother 32:1839, 1988
20. Cline MJ, Rothman B, Golde DW: Effect of endotoxin on the production of colony-stimulating factor by human monocytes and macrophages. J Cell Physiol 84:193, 1974
21. Navarro S, Debili N, Bernaudin J, Vainchenker W, Doly J: Regulation of the expression of IL-6 in human monocytes. J Immunol 142:4339, 1989
22. Greenberger J: The hematopoietic microenvironment. Crit Rev Oncol Hematol 11:65, 1991
23. Bron D, Lagneaux L, Delforge A, Otte C, Snoeck R, Stryckmans P: Prevention of CMV-induced myelosuppression by anti-CMV antibodies: An in vitro model. Exp Hematol 19:132, 1991
24. Dilloo D, Josting A, Burdach SI: CMV infection modulates interleukin-6 production in human bone marrow stroma cells. Bone Marrow Transplant 7:152, 1991 (abstr)
25. Almeida G, Porada C, St Jean S, Ascensao J: Human cytomegalovirus alters interleukin-6 production by endothelial cells. Blood 83:370, 1994
26. Berneman Z, Chen Z, Van Bockstaele D, Ramael M, Korthout M, Peetermans M: The nature of the adherent hemopoietic cells in human long-term bone marrow cultures (HLTBMCs): Presence of lymphocytes and plasma cells next to the myelomonocytic population. Leukemia 3:648, 1989
27. Birx D, Redfield R, Tencer K, Fowler A, Burke D, Tosato G: Induction of interleukin-6 during human immunodeficiency virus infection. Blood 76:2303, 1990
28. Nakajima K, Martinez-Maza O, Hirano T, Breen E, Nishanian P, Salazar-Gonzalez J, Fahey J, Kishimoto T. Induction of IL-6 (B cell stimulatory factor-2/IFN-β2) production by HIV. J Immunol 142:531, 1989
29. Becker S, Quay J, Soukup J: Cytokine (tumor necrosis factor, IL-6 and IL-8) production by respiratory syncytial virus-infected human alveolar macrophages. J Immunol 147:4307, 1991
30. Lal R, Rudolph D, Buckner C, Pardi D, Hooper C: Infection with human T-lymphotropic viruses leads to constitutive expression of leukemia inhibitory factor and interleukin-6. Blood 81:1827, 1993
31. Geist L, Monick M, Stinski M, Hunninghake G: The immediate early genes of human cytomegalovirus upregulate tumor necrosis factor-α gene expression. J Clin Invest 93:474, 1994
32. Turtinen L, Assimacopoulos A, Hasse A: Increased monokines in cytomegalovirus infected myelomonocytic cell cultures. Microb Pathog 7:135, 1989
33. Iwamoto G, Monick M, Clark D, Awon P, Stinski MF, Hunninghake GW: Modulation of interleukin-1 beta expression by the immediate early genes of human cytomegalovirus. J Clin Invest 85:1853, 1990
34. Ameglio F, Capobianchi M, Castilletti C, Cordiali Fei P, Fais S. Trento E, Dianzani F: Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells, correlation with the induction of other cytokines. Clin Exp Immunol 95:455, 1994
35. Dudding L, Garnett H: Interaction of strain AD169 and a clinical isolate of cytomegalovirus with peripheral monocytes: The effect of lipopolysaccharide stimulation. J Infect Dis 155:891, 1987
36. Simmons P, Kaushansky K, Torok-Storb B: Mechanisms of cytomegalovirus-mediated myelosuppression/Perturbation of stromal cells function versus direct infection of myeloid cells. Proc Natl Acad Sci USA 87:1386, 1990
37. Woodroffe S, Garnett H, Danis V, Layton J: Alteration in IL-1 alpha and IL-1 beta, G-CSF and GM-CSF secretion by endothelial cells infected with a clinical isolate of HCMV, in Michelson S and Platkin S (eds): Multidisciplinary approach to understanding cytomegalovirus disease. Amsterdam, The Netherlands, Elsevier Science, 1993, p 117
38. Sredni B, Rosenthal-Galili Z, Michlin H, Sobelman D, Seger Y, Blagerman S, Kalechman Y, Rager-Zisman B: Restoration of murine cytomegalovirus (MCMV) induced myelosuppression by AS101. Immunol Lett 43:159, 1994
39. Michelson S, Alcami J, Kim SJ, Danielpour D, Bachelerie F, Picard L, Bessiac C, Paya C, Virelizier JL: Human cytomegalovirus infection induces transcription and secretion of transforming growth factor β1. J Virol 68:5730, 1994
40. Kaposi K, Rice G: Cytomegalovirus infection of peripheral blood mononuclear cells: Effect on interleukin-1 and -2 production and responsiveness. J Virol 62:3603, 1988