Does paracellular permeability play a role in cholephilic dye-induced cholestasis?

Toxicology Letters

Volumn 84, Issue 1, 1996, Pages 13-22

  Roma, Marcelo G ^a   Crocenzi, Fernando A ^a   Rodríguez Garay, Emilio A ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Bile salts; Cholephilic dyes; Dye induced cholestasis; Paracellular permeability; Tight junctions

Indexed keywords

BROMOCRESOL GREEN; BROMSULFOPHTHALEIN; DYE; PHENOLSULFONPHTHALEIN; ROSE BENGAL; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE PERMEABILITY; CHOLESTASIS; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TIGHT JUNCTION;

ANIMALIA;

EID: 0030034083     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4274(95)03451-X     Document Type: Article

References (45)

1. Gregus, Z. and Klaassen, C.D. (1982) Comparison of biliary excretion of organic anions in mice and rats. Toxicol. Appl. Pharmacol. 63, 13-20.
2. Groszmann, R.J., Kotelanski, B., Kendler, J. and Zimmerman, H.J. (1969) Effect of sulfobromophthalein and indocyanine green on bile formation. Proc. Soc. Exp. Biol. Med. 132, 712-714.
3. Dhumeaux, D., Berthelot, P., Preaux, A.-M., Erlinger, S. and Faubert, R. (1970) A critical study of the concept of maximal biliary transport of sulfobromophthalein (BSP) in the Wistar rat. Rev. Eur. Etud. Clin. Biol. 15, 279-286.
4. Klaassen, C.D. and Watkins III, J.B. (1984) Mechanism of bile formation, hepatic uptake, and biliary excretion. Pharmacol. Rev. 36, 1-67.
5. Meijer, D.K.F. (1987) Current concepts on hepatic transport of drugs. J. Hepatol. 4, 259-268.
6. Killemberg, P.G. and Hoppel, C.L. (1974) Inhibition of rat liver mitochondrial oxidative phosphorylation by sulfobromophthalein. Mol. Pharmacol. 10, 108-118.
7. Laperche, Y. and Oueda, P. (1976) Inhibition by sulfobromophthalein of mitochondrial translocation of anions and adenine nucleotides: effects upon liver ATP-ase and possible correlation with inhibition of bile flow in the rat. J. Pharmacol. Exp. Ther. 197, 235-244.
8. Burr, R., Schwenk, M. and Pfaff, E. (1977) Interaction of bromosulphthalein with mitochondrial membranes -inhibition of respiration. Biochem. Pharmacol. 26, 461-466.
9. Fischer, E., Gregus, Z. and Varga, F. (1980) Effects of some cholephilic agents on hepatic mitochondrial respiration and biliary excretion. Arch. Toxicol. Suppl. 4, 343-345.
10. Laperche, Y., Launay A., Oueda, P., Doulin, A. and Baraud, J. (1972) Effect of phenobarbital and rose bengal on the ATP-ases of plasma membrane of rat and rabbit liver. Gut 13, 920-925.
11. ++-activated ATPase of rat liver in relation to cholestatic effects. Toxicol. Appl. Pharmacol. 43, 597-612.
12. Tazuma, S., Yamashita, G., Horikawa, K., Ohya, T., Aihara, N., Sagawa, H., Sasaki, M., Teramen, K., Ochi, H., Yamashita, I., Kajiyama, G. and Holzbach, R.T. (1993) A unique reversible cholestasis induced by organic anions: importance of its preferential association with intracellular and biliary lipid structures. Gastroenterology 104, A1006.
13. Boyer, J.L. (1983) Tight junctions in normal and cholestatic liver: does the paracellular pathway have functional significance? Hepatology 3, 614-617.
14. Krell, H. and Enderle, G.-J. (1993) Cholestasis: pathophysiology and pathobiochemistry. Z. Gastroenterol. 31, 11-15.
15. Krell, H., Höke, H. and Pfaff, E. (1982) Development of intrahepatic cholestasis by α-naphthylisothiocyanate in rats. Gastroenterology 82, 507-514.
16. Krell, H., Fromm, H. and Larson, R.E. (1991) Increased paracellular permeability in intrahepatic cholestasis induced by Carmustine (BCNU) in rats. Gastroenterology 101, 180-188.
17. Vu, D.D., Tuchweber, B., Raymond, P. and Yousef, I.M. (1992) Tight junction permeability and liver plasma membrane fluidity in lithocholate-induced cholestasis. Exp. Mol. Pathol. 57, 47-61.
18. Roma, M.G., Crocenzi F.A. and Rodriguez Garay, E.A. Effect of cholephilic dye on hepatic tight junctional permeability in the rat. Biochem. Pharmacol. (in press).
19. Layden, T.J., Elias, E. and Boyer, J.L. (1978) Bile formation in the rat: the role of the paracellular pathway. J. Clin. Invest. 62, 1375-1385.
20. Reichen, J, and Le, M. (1983) Taurocholate, but not taurodehydrocholate, increases biliary permeability to sucrose. Am. J. Physiol. 245, G651-G655.
21. Talalay, P. (1960) Enzymatic analysis of steroid hormones. Metab. Biochem. Anal. 8, 119-143.
22. Berthelot, P., Erlinger, S., Dhumeaux, D. and Preaux, A.M. (1970) Mechanism of phenobarbital induced hypercholeresis in the rat. Am. J. Physiol. 219, 808-813.
23. Hart, L.G. and Schanker, L.S. (1966) The chemical forms in which phenol red is secreted into bile of rats. Proc. Soc. Exp. Biol. Med. 123, 433-435.
24. Whelan, F.J. and Plaa, G.L. (1963) The application of thin layer chromatography to sulfobromophthalein metabolism studies. Toxicol. Appl. Pharmacol. 5, 457-463.
25. Roma, M.G., Luque, E.A., Marinelli, R.A. and Rodriguez Garay, E.A. (1989) A simple method for the correction of biliary excretion curves distorted by the biliary dead space. Biochem. Pharmacol. 38, 4021-4025.
26. Fischer, E. and Varga, F. (1984) Effect of taurocholate pretreatment on biliary excretion of exogenous organic anions in rats. Arch. Intern. Pharmacodyn. Ther. 267, 187-199.
27. Snedecor, G.W. and Cochran, W.G. (1967) Statistical Methods. Iowa State University Press, Ames, IA.
28. Graf, J. (1983) Canalicular bile salt-independent bile formation: concepts and clues from electrolyte transport in rat liver. Am. J. Physiol. 244, G233-G246.
29. Lake, J.R., Vojtech, L., Van Dyke, R.W. and Scharschmidt, B.F. (1985) Biliary secretion of fluid-phase markers by the isolated perfused rat liver: role of transcellular vesicular transport. J. Clin. Invest. 76, 676-684.
30. Jaeschke, H., Krell, H. and Pfaff, E. (1987) Quantitative estimation of transcellular and paracellular pathways of biliary sucrose in isolated perfused rat liver. Biochem. J. 241, 635-640.
31. Elias, E., Hruban, Z., Wade, J.B. and Boyer, J.L. (1980) Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability. Proc. Natl. Acad. Sci. USA 77, 2229-2233.
32. Shaffer, E.A. and Roy, M.P. (1981) Effects of sulfobromophthalein excretion on biliary lipid secretion in humans and dogs. Am. J. Physiol. 240, G85-G89.
33. Apstein, M.D. and Robins, S.J. (1982) Effect of organic anions on biliary lipids in the rat. Gastroenterology 83, 1120-1126.
34. Apstein, M.D. (1984) Inhibition of biliary phospholipid and cholesterol secretion by bilirubin in the Sprague-Dawley and Gunn rats. Gastroenterology 87, 634-638.
35. Mesa, V.A., De Groote, J. and Fevery, J. (1990) Increase in the relative amount of bilirubin diconjugates in rat bile and serum under infusion of phthaleins and indocyanine green. J. Hepatol. 10, 35-40.
36. Aoyama, N., Zeniya, M., Arashiyama, Y., Hihara, M. and Kameda, H. (1988) The effect of bilirubin on biliary lipid secretion: analysis by horseradish peroxidase associated intrahepatic vesicular transport system. Gastroenterol. Jpn. 23, 652-657.
37. Dhumeaux, D., Berthelot, P., Preaux, A.-M. and Erlinger, S. (1970) A critical study of the concept of maximal biliary transport of sulfobromophthalein (BSP) in the Wistar rat. Rev. Eur. Etud. Clin. Biol. 15, 279-286.
38. Winklhofer-Roob, B.M., McKim, Jr., J.M., Devereaux, M.W. and Sokol, R.J. (1994) Increased generation of hydrogen peroxide by isolated rat hepatic mitochondria exposed to chenodeoxycholic acid. Hepatology 20, 180A.
39. Konno, H., Lowe, P.J., Hardison, W.G., Miyai, K., Nakamura, S. and Baba, S. (1992) Breakdown of hepatic tight junctions during reoxygenation injury. Transplantation 53, 1211-1214.
40. Hill, T.L. and Kirschner, M.W. (1983) Bioenergetics and kinetics of microtubule and actin filaments assembly-disassembly. Int. Rev. Cytol. 78, 1-125.
41. Korn, E.D., Carlier, M.F. and Pantaloni, D. (1987) Actin polymerization and ATP hydrolysis. Science 238, 638-644.
42. 2+ oscillations in cultured rat hepatocytes by chemical hypoxia. J. Biol. Chem. 266, 20062-20069.
43. Lowe, P.J., Miyai, K., Steinbach, J.H. and Hardison, W.G.M. (1988) Hormonal regulation of hepatocyte tight junctional permeability. Am. J. Physiol. 255, G454-G461.
44. Kan, K.S. and Coleman, R. (1988) The calcium ionophore A23187 increases the tight-junctional permeability in rat liver. Biochem. J. 256, 1039-1041.
45. Llopis, J., Kass, G.E.N., Duddy, S.K., Farell, G.C., Gahm, A. and Orrenius, S. (1991) Mobilization of the hormone sensitive calcium pool increases hepatocyte tight junctional permeability in the perfused rat liver. FEBS Lett. 280, 84-86.