Comparison of the activity of nebracetam enantiomers in enhancing the release of acetylcholine from the isolated dog stellate ganglia

Pharmacometrics

Volumn 51, Issue 1, 1996, Pages 29-32

  Yamada, Hiromi ^c   Kushiku, Kazushi ^a   Kohno, Yasuko ^b   Furukawa, Tatsuo ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^c NONE

Author keywords

(+) , ( ) Nebracetam; (dogs); Acetylcholine; Stellate ganglia

Indexed keywords

ACETYLCHOLINE; HEMICHOLINIUM 3; NEBRACETAM FUMARATE;

ANIMAL TISSUE; ARTICLE; DOG; DRUG ACTIVITY; DRUG EFFECT; ENANTIOMER; NONHUMAN; RACEMIC MIXTURE; STELLATE GANGLION; STEREOSPECIFICITY;

EID: 0030033932     PISSN: 03008533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Eva, C., Hadjiconstantinou, M., Neff, N.H. and Meek, J.L. (1984): Acetylcholine measurement by high pressure liquid chromatography using and enzyme-loaded post-column reactor, Anal. Biochem., 143, 320-324.
2. Kushiku, K., Ohjimi, H., Yamada, H. and Furukawa, T. (1991): Presynaptic facilitation, by the new nootropic drug nebracetam, of ganglionic muscarinic transmission in the dog cardiac sympathetic ganglion, Arzneim. -Forsch./Drug Res., 41, 1113-1118.
3. Ohjimi, H., Kushiku, K., Yamada, H., Kuwahara, T., Kohno, Y. and Furukawa, T. (1994): Increase of acetylcholine release by nebracetam in dog cardiac sympathetic ganglion, J. Pharmacol. Exp. Ther., 268, 396-402.
4. Potter, P.E., Meek, J.L. and Neff, N.H. (1983): Acetylcholine and choline in neuronal tissue measured by HPLC with electrochemical detection, J. Neurochem., 41, 188-194.
5. Shibata, S., Kagami-ishi, Y., Ueki, S. and Watanabe, S. (1992): Neuroprotective effect of WEB 1881 FU (Nebracetam) on an ischemia-induced deficit of glucose uptake in rat hippocampal cerebral coritcal slices and CA1 field potential in hippocampal slices, Japan. J. Pharmacol., 58, 243-250.