Suppression of cerebral metabolic rate for oxygen (CMRO2) by mild hypothermia compared with thiopental

Journal of Neurosurgical Anesthesiology

Volumn 8, Issue 1, 1996, Pages 52-59

  Nemoto, Edwin M ^a   Klementavicius, R ^a   Melick, John A ^a   Yonas, Howard ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Brain; Brain protection; Cerebral blood flow; Cerebral metabolic rate of oxygen

Indexed keywords

NITROUS OXIDE; OXYGEN; THIOPENTAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; BRAIN PROTECTION; BRAIN TEMPERATURE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; HYPOTHERMIA; MALE; METABOLIC RATE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030033666     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008506-199601000-00012     Document Type: Article

References (34)

1. Sano T, Drummond JC, Patel PM, Grafe MR, Watson JC, Cole DJ. A comparison of the cerebral protective effects of isoflurane and mild hypothermia in a model of incomplete forebrain ischemia in the rat. Anesthesiology 1992;76:221-8.
2. Minamisawa H, Nordstrom C-H, Smith M-L, Siesjo BK. The influence of mild body and brain hypothermia on ischemic brain damage. J Cereb Blood Flow Metab 1990;10:365-74.
3. Baughman VL, Hoffman WE, Thomas C, Miletich DJ, Albrecht RF. Hypothermia versus ethanol: neurologic outcome after incomplete cerebral ischemia in midazolam anesthetized rats. J Neurosurg Anesth 1990;2:290-5.
4. Clifton GL, Taft WC, Blair RE, Choi SC, DeLorenzo RJ. Conditions for pharmacologie evaluation in the gerbil model of forebrain ischemia. Stroke 1989;20:1545-52.
5. Clifton GL, Jiang JY, Lyeth BG, Jenkins LW, Hamm RJ, Hayes RL. Marked protection by moderate hypothermia after experimental traumatic brain injury. J Cereb Blood Flow Metab 1991;11:114-21.
6. Haggerdal M, Harp JR, Nilsson L, Siesjo BK. The effect of induced hypothermia upon oxygen consumption in the rat brain. J Neurochem 1975;24:311-6.
7. Michenfelder JD. The interdependency of cerebral functional and metabolic effects following massive doses of thiopental in the dog. Anesthesiology 1974;41:231-6.
8. Steen PA, Newberg L, Milde JH, Michenfelder JD. Hypothermia and barbiturates: individual and combined effects on canine cerebral oxygen consumption. Anesthesiology 1983; 58:527-32.
9. Michenfelder JD. Anesthesia and the brain: clinical, functional, metabolic and vascular correlates. New York: Churchill Livingstone, 1988:35-48.
10. Astrup J, Sorensen PM, Sorensen HR. Inhibition of cerebral oxygen and glucose consumption in the dog by hypothermia, pentobarbital, and lidocaine. Anesthesiology 1981;55:263-8.
11. Gjedde A, Caronna JJ, Hindfelt B, Plum F. Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia. Am J Physiol 1975;229:113-8.
12. 2) after complete global brain ischemia in rats. In: Mochizuki M, Honig CR, Koyama T, Goldstick TK, Bruley DF, eds. Oxygen transport to tissue X. New York: Plenum Publishing, 1988:391-6. (Advances in experimental medicine, vol. 222).
13. Carlsson C, Hagerdal M, Kaasik AE, Siesjo BK. A catecholamine-mediated increase in cerebral oxygen uptake during immobilization stress in rats. Brain Res 1977;119:223-31.
14. Singh NC, Kochanek PM, Schiding JK, Melick JA, Nemoto EM. Uncoupled cerebral blood flow and metabolism after severe global ischemia in rats. J Cereb Blood Flow Metab 1992;12:802-8.
15. Lafferty JJ, Keykhah MM, Shapiro HM, Van Horn K, Behar MG. Cerebral hypometabolism obtained with deep pentobarbital anesthesia and hypothermia (30°C). Anesthesiology 1978;49:159-64.
16. Siesjo BK. In: Brain energy metabolism. New York: John Wiley and Sons, 1978.
17. 2) in rats. Crit Care Med 1995;23:A246.
18. Nemoto EM, Yao L, Yonas H, Darby JM. Compartmentation of whole brain blood flow and oxygen and glucose metabolism in monkeys. J Neurosurg Anesth 1994;6(3):170-4.
19. Batjer HH. Cerebral protective effects of etomidate: experimental and clinical aspects. Cerebrovasc Brain Metab Rev 1993;5:17-32.
20. Frizzell RT, Fichtel FM, Jordan MB, et al. Effects of etomidate and hypothermia on cerebral metabolism and blood flow in a canine model of hypoperfusion. J Neurosurg Anesth 1993;5:104-10.
21. Newberg LA, Milde JH, Michenfelder JD. Cerebral functional, metabolic, and hemodynamic effects of etomidate in dogs. Anesthesiology 1985;63:371-7.
22. Newberg LA, Milde JH, Michenfelder JD. The cerebral metabolic effects of isoflurane at and above concentrations that suppress cortical electrical activity. Anesthesiology 1983;59: 23-8.
23. Marshall LF, Smith RW, Shapiro HM. The outcome with aggressive treatment in severe head injuries. I. The significance of intracranial pressure monitoring. J Neurosurg 1979; 50:20-5.
24. Shapiro HM. Barbiturates in brain ischemia. Br J Anaesth 1985;57:82-95.
25. Cain SM. Peripheral oxygen uptake and delivery in health and disease. Clin Chest Med 1983;4:139-48.
26. Cooper CE, Matcher SJ, Wyatt JS, et al. Near-i.r. spectroscopy of the brain: relevance to cytochrome oxidase bioenergetics. Biochem Soc Trans 1994;22:974-80.
27. 2 supply dependence. J Appl Physiol 1992;72:1499-505.
28. Back T, Kohno K, Hossmann K-A. Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: effect on blood flow, tissue oxygenation and electroencephalogram. J Cereb Blood Flow Metab 1994;14:12-9.
29. Todd MM, Chadwick HS, Shapiro HM, Dunlop BJ, Marshall LF, Dueck R. The neurologic effects of thiopental therapy following experimental cardiac arrest in cats. Anesthesiology 1982;57:76-86.
30. Lin B, Dietrich DW, Busto R, Kraydieh S, Globus MY-T, Ginsberg MD. Postischemic brain hypothermia combined with delayed MK-801 treatment protects chronically after global ischemia in rats. Presented at the 19th International Joint Conference on Stroke and Cerebral Circulation, San Diego, California, February 17-19, 1994. Stroke 1994;25(1): 254.
31. Dietrich WD, Busto R, Alonso O, Globus MY, Ginsberg MD. Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metab 1993;13:541-9.
32. Ames III A, Maynard KI, Kaplan S. Protection against CNS ischemia by temporary interruption of function-related processes of neurons. J Cereb Blood Flow Metab 1995;3:433-9.
33. Gjedde A. Interpreting physiology maps of the living brain. Ann Nucl Med 1993;7(suppl):S19-20.
34. Andersen BJ, Marmarou A. Functional compartmentalization of energy production in neural tissue. Brain Res 1992; 585:190-5.