Endothelial Gi protein expression is markedly low in human coronary microvessels

Journal of Cardiovascular Pharmacology

Volumn 27, Issue 2, 1996, Pages 297-302

  Shimokawa, Hiroaki ^a   Tsutsui, Masato ^b   Mizuki, Tsunetaka ^b   Hase, Kazunori ^b   Kuwaoka, Isao ^b   Nogami, Naoe ^b   Okamatsu, Shuichi ^b   Nakanishi, Kazuo ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b ASO IIZUKA HOSPITAL   (Japan)

Author keywords

Coronary microvessels; Endothelium dependent relaxation; Endothelium derived relaxing factor; Gi proteins; Nitric oxide; Pertussis toxin

Indexed keywords

ENDOTHELIUM DERIVED RELAXING FACTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN;

ANTIBODY SPECIFICITY; ARTICLE; CORONARY ARTERY BLOOD FLOW; CORONARY BLOOD VESSEL; ENDOTHELIUM CELL; ENZYME ACTIVATION; EPICARDIUM MAPPING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROVASCULATURE; PRIORITY JOURNAL; VASA VASORUM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CHILD; CHILD, PRESCHOOL; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; GTP-BINDING PROTEINS; HUMANS; INFANT; INFANT, NEWBORN; MALE; MICROCIRCULATION; MIDDLE AGED; MUSCLE RELAXATION; VASA VASORUM;

EID: 0030033539     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199602000-00018     Document Type: Article

References (32)

1. Radbell M. Programmable messengers: a new theory of hormone action. Trends Biochem Sci 1985;7:461-4.
2. Dolphin AC. Nucleotide binding proteins in signal transduction in health and disease. Trends Neurosci 1987;10:53-7.
3. Dahlman HG, Caron MG, Lefkowitz RJ. A family of receptors coupled to guanine regulatory proteins. Biochemistry 1987;26:2657-64.
4. Casey PJ, Gilman AG. G-Protein involvement in receptor effector coupling. J Biol Chem 1988;263:2577-80.
5. Flavahan NA, Shimokawa H, Vanhoutte PM. Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries. J Physiol 1989;408: 549-60.
6. Shimokawa H, Flavahan NA, Vanhoutte PM. Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Circ Res 1989;65:740-53.
7. Richard V, Tanner FC, Tschudi M, Lüscher T. Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries. Am J Physiol 1990;259: H1433-9.
8. Shimokawa H, Flavahan NA, Vanhoutte PM. Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries. Circulation 1991;83:652- 60.
9. Tsutsui M, Shimokawa H, Tanaka S, et al. Endothelial Gi protein in human coronary arteries. Eur Heart J 1994;15: 1261-6.
10. Furchgott RF, Carvalho MH, Khan MT, Matsunaga K. Evidence for endothelium-dependent vasodilation of resistance vessels by acetylcholine. Blood Vessels 1987;24:145-9.
11. Stewart DJ, Münzel T, Bassenge E. Reversal of acetylcholine-induced coronary resistance vessel dilation by hemoglobin. Eur J Pharmacol 1987;136:239-42.
12. Förstermann U, Dudel C, Frölich JC. Endothelium-derived relaxing factor is most likely to modulate the tone of resistance arteries in the rabbit hindlimb in vivo. J Pharmacol Exp Ther 1987;243:1055-61.
13. Aalkjaer C, Heagerty AM, Swales JD, Thurston H. Endothelium-dependent relaxation in human subcutaneous resistance vessels. Blood Vessels 1987;24:85-8.
14. Vallance P, Collier J, Moncada S. Effects of endothelium- derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989;2:997-9.
15. Griffith TM, Edwards DH, Davies RLL, Harrison TJ, Evans KT. EDRF coordinates the behavior of vascular resistance vessels. Nature 1987;329:442-5.
16. Tschudi M, Richard V, Bühler FR, Lüscher TF. Importance of endothelium-derived nitric oxide in porcine coronary resistance arteries. Am J Physiol 1991;260:H13-20.
17. Heitzmann H, Richards FM. Use of the avidin-biotin complex for specific staining of biological membranes in electron microscopy. Proc Natl Acad Sci USA 1974;71:3537-41.
18. Heggeness MH, Ash JF. Use of the avidin-biotin complex for the localization of actin and myosin with fluorescence microscopy. J Cell Biol 1977;73:783-8.
19. Goldsmith P, Gierscik P, Milligan G, et al. Antibodies directed against synthetic peptides distinguish between GTP binding proteins in neutrophil and brain. J Biol Chem 1987; 262:14683-8.
20. i3 complementary DNA. J Biol Chem 1988;263:6476-9.
21. q family. J Biol Chem 1991;266:9309-13.
22. Burgdorf WHC, Mukai K, Rosai J. Immunohistochemical identification of factor VIII-related antigen in endothelial cells of cutaneous lesions of alleged vascular nature. Am J Clin Pathol 1981;75:167-71.
23. Sehested M, Hou-Jensen K. Factor VIII related antigen as an endothelial cell marker in benign and malignant diseases. Virchows Arch [A] 1981;391:217-25.
24. Vanhoutte PM, Shimokawa H. Endothelium-derived relaxing factor and coronary vasospasm. Circulation 1989;80:1-9.
25. Nakaike R, Shimokawa H, Takayanagi T, Fujii K. Hyperpolarizing mechanism becomes more important as the vessel diameter becomes smaller in endothelium-dependent relaxations. Circulation 1994;90:I-88.
26. Flavahan NA. Atherosclerosis or lipoprotein-induced endothelial dysfunction: potential mechanisms underlying the reduction in EDRF/nitric oxide activity. Circulation 1992;85: 1927-38.
27. Sellke FW, Armstrong ML, Harrison DG. Endothelium- dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation 1990;81:1586-93.
28. Chilian WM, Dellsperger KC, Layne SM, et al. Effects of atherosclerosis on the coronary microcirculation. Am J Physiol 1990;258:H529-39.
29. Kuo L, Davis MJ, Cannon S, Chilian WM. Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation: restoration of endothelium- dependent responses by L-arginine. Circ Res 1992;70:465- 76.
30. Barger AC, Beeuwkes III R, Lainey LL, Silverman KJ. Hypothesis: vasa vasorum and neovascularization of human coronary arteries. N Engl J Med 1984;310:175-7.
31. Williams JK, Armstrong ML, Heistad DD. Vasa vasorum in atherosclerotic coronary arteries: responses to vasoactive stimuli and regression of atherosclerosis. Circ Res 1988;62: 515-23.
32. Crotty TP. The role of vasa vasorum in atherosclerosis. Med Hypotheses 1989;28:233-43.