An unusual cerebellar primitive neuroectodermal tumor with t(11;22) translocation: Pathological and molecular analysis

Pediatric Pathology and Laboratory Medicine

Volumn 16, Issue 1, 1996, Pages 119-128

  Jay, Venita ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

brain neoplasm; chromosomal translocation; medulloblastoma; polymerase chain reaction; primitive neuroectodermal tumor

Indexed keywords

ALCIAN BLUE; GLYCOSAMINOGLYCAN; NEURON SPECIFIC ENOLASE; SYNAPTOPHYSIN;

ARTICLE; CANCER SURGERY; CASE REPORT; CELL GRANULE; CEREBELLUM TUMOR; CHROMOSOME TRANSLOCATION 11; ELECTRON MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTERMEDIATE FILAMENT; LEPTOMENINX; MALE; METASTASIS; MICROTUBULE; NEUROECTODERM TUMOR; PRESCHOOL CHILD; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ROUGH ENDOPLASMIC RETICULUM;

CEREBELLAR NEOPLASMS; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 22; HUMANS; MALE; NEUROECTODERMAL TUMORS, PRIMITIVE; POLYMERASE CHAIN REACTION; TRANSLOCATION, GENETIC;

EID: 0030033148     PISSN: 10771042     EISSN: None     Source Type: Journal    
DOI: 10.1080/107710496175949     Document Type: Article

References (15)

1. Donner LR. Cytogenetics and molecular biology of small round-cell tumors and related neoplasms. Cancer Genet Cytogenet 1991;54:1-10.
2. Potluri VR, Gilbert F, Helsen C, Helson L. Primitive neuroectodermal tumor cell lines: Chromosomal analysis of five cases. Cancer Genet Cytogenet 1987;24:75-86.
3. Whang-Peng J, Triche TJ, Knutsen T, et al. Cytogenetic characterization of selected small round cell tumors of childhood. Cancer Genet Cytogenet 1986;21:185-208.
4. Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumors. Nature 1992;359:162-5.
5. Sorensen, PHB, Liu XF, Delattre O, et al. Reverse transcriptase PCR amplification of EWS/FLI-1 fusion transcripts as a diagnostic test for peripheral primitive neuroectodermal tumors of childhood. Diagn Mol Pathol 1993;2:147-57.
6. Zucman J, Delattre O, Desmaze C, et al. Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints. Genes Chromosom Cancer 1992; 5:271-7.
7. Jay V, Pienkowska M, Becker LE, Zielenska M. Primitive neuroectodermal tumors of the cerebrum and cerebellum: Absence of t(11;22) translocation by RT-PCR analysis. Mod Pathol 1995;8:488-96.
8. Downing JR, Head DR, Curcio-Brint AM, et al. An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21) (q22;q22) translocation. Blood 1993;81:2860-5.
9. Tsokos M. Peripheral primitive neuroectodermal tumors. Diagnosis, classification, and prognosis. Perspect Pediatr Pathol 1992;16:27-98.
10. Downing JR, Head DR, Parha DM, et al. Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction. Am J Pathol 1993;143:1294-1300.
11. Turc-Carel C, Aurias A, Mugneret F, et al. Chromosomes in Ewing's sarcoma. 1. An evaluation of the remarkable consistency of t(11;22) (q24;q12). Cancer Genet Cytogenet 1988;32:229-38.
12. Biegel JA, Rorke I.B, Packer RJ, et al. Isochromosome 17q in primitive neuroectodermal tumors of the central nervous system. Genes Chromosom Cancer 1989;1:139-47.
13. Griffin CA, Hawkins AL, Packer RJ, Rorke LB, Emanuel BS. Chromosome abnormalities in pediatric brain tumors. Cancer Res 1988;48:175-80.
14. Karnes PS, Tran TN, Cui MY, et al. Cytogenetic analysis of 39 pediatric central nervous system tumors. Cancer Genet Cytogenet 1992;59:12-9.
15. James CD, He J, Carlbom E, et al. Loss of genetic information in central nervous system tumors common to children and young adults. Genes Chromosom Cancer 1990;2:94-102.