Biochemical characterization of the effects of the benzodiazepine, midazolam, on mitochondrial electron transfer

Pharmacology and Toxicology

Volumn 78, Issue 2, 1996, Pages 69-76

  Colleoni, Mariapia ^a   Costa, Barbara ^a   Gori, Enzo ^a   Santagostino, Angela ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; 3 HYDROXYBUTYRIC ACID; ADENOSINE DIPHOSPHATE; ASCORBIC ACID; BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR; CITRATE SYNTHASE; CITRININ; CYTOCHROME C; CYTOCHROME C OXIDASE; CYTOCHROME C1; HYPNOTIC AGENT; MIDAZOLAM; MIDAZOLAM MALEATE; N,N,N',N' TETRAMETHYL 1,4 PHENYLENEDIAMINE; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID; UBIQUINOL CYTOCHROME C REDUCTASE; UBISEMIQUINONE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROCHEMICAL DETECTION; ELECTRON TRANSPORT; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; SPECTROPHOTOMETRY;

ANIMALIA;

EID: 0030033035     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1996.tb00182.x     Document Type: Article

References (52)

1. Anholt, R. R. H.: Mitochondrial benzodiazepine receptors as potential modulators of intermediary metabolism. Trends Pharmaccol. Sci. 1986, 7, 506-511.
2. Anholt, R. R. H., P. L. Pedersen, E. B. Souza & S. H. Snyder: The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J. Biol. Chem. 1986, 261, 576-583.
3. Bender, A. S. & L. Hertz: Pharmacological evidence that the nonneuronal binding site in primary cultures of glial cells is associated with a calcium channel. Eur. J. Pharmacol. 1985, 110, 287-288.
4. Birch-Machin, M. A., I. M. Shepherd, N. J. Watmough, H. Stanley, A. Sherratt, K. Bartlett, V. M. Darley-Usmar, D. W. A. Milligan, R. J. Welch, A. Aynsley-Green & D. M. Turnbull: Fatal lactic acidosis in infancy with a defect of complex III of the respiratory chain. Pediatr. Res. 1989, 25, 553-559.
5. Bookelman, H., J. M. F. Trijbels, R. C. A. Sengers & A. J. M. Janssen: Measurement of cytochromes in human skeletal muscle mitochondria, isolated from fresh and frozen stored muscle specimens. Biochem. Med. 1978, 19, 366-373.
6. Bourguignon, J. J.: Endogenous and synthetic ligands of mitochondrial benzodiazepine receptors: structure-affinity relationships. In: Peripheral benzodiazepine receptors. Ed.: E. Giesen-Crouse. Academic Press, San Diego, 1993, pp. 59-85.
7. Boveris, A., R. Oshino, M. Erecinska & B. Chance: Reduction of mitochondrial components by durohydroquinone. Biochem. Biophys. Acta 1971, 245, 1-16.
8. 3H] diazepam binding. Proc. Natl. Acad. Sci. 1977, 74, 3805-3809.
9. Chance, B. & G. R. Williams: Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J. Biol. Chem. 1955, 217, 383-393.
10. Chance, B. & G. R. Williams: The respiratory chain and oxidative phosphorylation. Advances Enzym. 1956, 17, 65-134.
11. Code, W. D., H. S. White & L. Hertz: The effect of midazolam on calcium signaling in astrocytes. Ann. N. Y. Acad. Sci. 1991, 625, 430-432.
12. Colleoni, M., L. Gadda, A. Santagostino & E. Gori: Neurodepressants as mitochondrial drugs. 5th World Congr. Biol. Psychiatry, Firenze, June 9 14 1991, Abstract p. 159.
13. Colleoni, M., M. Sala, A. Santagostino, D. Braida, P. Calcaterra, M. P. Leone & T. Zavanella: Oral benzodiazepine or voluntary alcohol consumption in rats and their behavioral and liver biochemical correlates. In: Addiction researrh foundation of Italy; monograph series. Vol. 7. Eds.: P. F. Mannaioni & E. Masini. Turato & Editron, Padova, 1994, pp. 155-159.
14. Colleoni, M., B. Costa, L. Gadda, E. Gori & A. Santagostino: Markers of toxicity and drug metabolic activation following ethanol and benzodiazepine simultaneously orally administration in rats for a protracted period. Pharmacology & Toxicology 1995, 76 (Suppl. 1), 17.
15. Darley-Usmar, V. M., R. A. Capaldi, S. Takamiya, F. Millett, M. T. Wilson, F. Malatesta & P. Sarti: Reconstitution and molecular analysis of the respiratory chain. In: Mitochondria: A practical approach. Eds.: V. M. Darley-Usmar, D. Rickwood & M. T. Wilson. IRL Press, Oxford, Washington, 1987, pp. 113-152.
16. Daval, J. L., R. M. Post & P. J. Marangos: Pyruvate dehydrogenase interactions with peripheral-type benzodiazepine receptors. J. Neurochem. 1989, 52, 110-116.
17. Davis, L. F., E. E. Gatz & J. R. Jones: Effects of chlordiazepoxide and diazepam on respiration and oxidative phosphorylation in rat brain mitochondria. Biochem. Pharmacol. 1971, 20, 1883-1887.
18. Drugan, R. C. & P. V. Holmes: Central and peripheral benzodiazepine receptors: involvement in an organism's response to physical and psychological stress. Neurosci. Biobehav. Rev. 1991, 15, 277-298.
19. Ernster, L. & K. Nordenbrand: Skeletal muscle mithocondria. In: Methods in enzymology, Vol. 10. Eds.: R. W. Estabrook & M. F. Pullman. Academic Press, New York, London, 1967, pp. 86-94.
20. Finney, D. J.: Statistical method in biological assay. Charles Griffin & Co. Ltd, London High Wycombe, 1978.
21. Gerecke, M.: Chemical structure and properties of midazolam compared with other benzodiazepines. Br. J. Clin. Pharmacol. 1983, 16, 11S-16S.
22. Hatefi, Y.: Preparation and properties of NADH: Ubiquinone oxidoreductase (Complex I). In: Methods in enzymology, Vol. 53. Eds.: S. Fleischer & L. Packer. Academic Press, New York, 1978, pp. 11-14.
23. Hatefi, Y. & D. L. Stiggal: Preparation and properties of Succinate: Ubiquinone oxidoreductase (Complex II). In: Methods in enzymology. Vol. 53. Eds.: S. Fleischer & L. Packer. Academic Press, New York, 1978, pp. 21-27.
24. Hertz, L.: Binding characteristics of the receptor and coupling to transport proteins. In: Peripheral benzodiazepine receptors. Ed.: E. Giesen-Crouse. Academic Press, San Diego, 1993, pp. 27-57.
25. Hirsch, J. D., C. F. Beyer, L. Malkowitz, B. Beer & A. J. Blume: Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control. Mol. Pharmacol. 1988, 34, 157-163.
26. Kanto, J., L. Kangas & T. Siirtola: Ccrebrospinal concentrations of diazepam and its metabolites in man. Acta Pharmacology & Toxicology 1975, 36, 328-334.
27. 2 consumption of neuroblastoma cells. Eur. J. Pharmacol. 1989, 161, 197-202.
28. Lovett, G. S. & A. J. Sweetman: The analysis of drug action on mitochondrial oxidative phosphorylation. The choice of organic solvent for water-insoluble drugs. Meth. Find. Exptl. Clin. Pharmacol. 1983, 5, 695-699.
29. Lowry, O. H., N. J. Rosebrough, A. L. Farr & R. J. Randall: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193, 265-275.
30. Marty, J., A. Nitenberg, F. Blanchet, S. Zouioueche & J. M. Desmonts: Effects of midazolam on the coronary circulation in patients with coronary artery disease. Anesthesiology 1986, 64, 206-210.
31. Moreno-Sanchez, R., B. A. Hogue, C. Bravo, A. H. Newman, A. S. Basile & P. K. Chiang: Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086. Biochem. Pharmacol. 1991, 41, 1479-1484.
32. Mukhin, A. G., V. Papadopoulos, E. Costa & K. E. Krueger: Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. Proc. Natl. Acad. Sci. 1989, 86, 9813-9816.
33. Myers, R.: Mitochondrial benzodiazepine receptor ligands as indicators of damage in the CNS: their application in positron emission tomography. In: Peripheral benzodiazepine receptors. Ed.: E. Giesen-Crouse. Academic Press, San Diego, 1993, pp. 235-273.
34. Nugent, M., A. A. Artru & J. D. Michenfelder: Cerebral metabolic, vascular and protective effects of midazolam maleate. Anesthesiology 1982, 56, 172-176.
35. Papadopoulos, V., F. B. Nowzari & K. E. Krueger: Hormone-stimulated steroidogenesis is coupled to mitochondrial benzodiazepine receptors. J. Biol. Chem. 1991, 266, 3682-3687.
36. Polc, P.: Electrophysiology of benzodiazepine receptors ligand, multiple mechanisms and sites of action. Progr. Neurobiol. 1988, 31, 349-423.
37. Ragan, C. L. M. T. Wilson, V. M. Darley-Usmar & P. N. Lowe: Sub-fractionation of mitochondria and isolation of the proteins of oxidative phosphorylation. In: Mitochondria: A practical approach. Eds.: V. M. Darley-Usmar, D. Rickwood & M. T. Wilson. IRL Press, Oxford, Washington, 1987, pp. 79-112.
38. Rampe, D. & D. J. Triggle: Benzodiazepines and calcium channel function. Trends Pharmacol. Sci. 1986, 7, 461-464.
39. Ramsay, R. R. & T. P. Singer: Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria. J. Biol. Chem. 1986, 261, 7585-7587.
40. Robinson, J. B., L. G. Brent, B. Sumegi & P. A. Srere: An enzymatic approach to the study of the Krebs tricarboxylic acid cycle. In: Mitochondria: A practical approach. Eds.: V. M. Darley-Usmar, D. Rickwood & M. T. Wilson. IRL Press, Oxford, Washington, 1987, pp. 153-170.
41. Sherrat, H. S. A., N. J. Watmough, M. A. Johnson & D. M. Turnbull: Methods for study of normal and abnormal skeletal muscle mitochondria. Methods Biochem. Anal. 1989, 33, 243-335.
42. Slater, E. C. & W. D. Bonner: The effect of fluoride on the succinic oxidase system. Biochem. J. 1952, 52, 186-196.
43. Smith, L.: Spectrophotometric assay of cytochrome oxidase. Methods Biochem. Anal. 1955, 2, 427-434.
44. Sordahl, L. A., C. Johnson, Z. R. Blailock & A. Schwartz: The mitochondrion. In: Methods in pharmacology, Vol. 1. Ed.: A. Schwartz. Appleton-Century-Crofts Educational Division Meredith Corporation, New York, 1971, pp. 247-286.
45. Srere, P. A.: Citrate synthase. In: Methods in enzymology, Vol. 13. Ed.: J. M. Lowenstein. Academic Press, New York, 1969, pp. 3-11.
46. Takada, M., S. Ikenoya, T. Yuzuriha & K. Katayama: Studies on reduced and oxidized coenzyme Q (Ubiquinones). II. The determination of oxidation-reduction levels of coenzyme Q in mitochondria, microsomes and plasma by high-performance liquid chromatography. Biochim. Biophys. Acta 1982, 679, 308-314,
47. Tallman, J. F., S. M. Paul, P. Skolnich & D. W. Gallanger: Receptors lor the age of anxiety: pharmacology of benzodiazepine. Science 1980, 207, 274-281.
48. 1 segment in electron-transfer and energy-conserving reactions of the mitochondrial respiratory chain. Biochim. Biophys. Acta 1981, 639, 129-155.
49. Verma, A. & S. H. Snyder: Peripheral-type benzodiazepine receptors. Ann. Rev. Pharmacol, Toxicol. 1989, 29, 307-322.
50. 1 complex. J. Biol. Chem. 1984, 259, 6318-6326.
51. Yanagibashi, K., Y. Ohno, N. Nakamichi, T. Matsui, K. Hayashida, M. Takamura, K. Yamada, S. Ton & M. Kawamura: Peripheral type benzodiazepine receptors are involved in the regulation of cholesterol side chain cleavage in adrenocortical mitochondria. J. Biochem. 1989, 106, 1026-1029.
52. Zar, J. H.: Biostatistical analysis. Prentice-Hall Inc., Englewood Cliffs, 1974.